MAY 29, 2015 08:00 AM PDT
The Role of Thrombin Time in the Clinical Laboratory
Presented at the Stago EdVantage Virtual University Virtual Event
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  • Supervisor, Special Coagulation and Hematology, New York Presbyterian- Columbia
      Presently, I am both the Supervisor of Special Coagulation and the QA Manager for Specialty Testing at New York Presbyterian Hospital- Columbia. I also am an adjunct professor at SUNY Stony Brook, New York and a guest lecturer at Rutgers in New Jersey. I have given hundreds of lectures on coagulation throughout the world, and presented posters at many conferences. One of my passions is writing, and I have published over 100 articles and worked on 5 text books. I have 32 years of clinical laboratory experience and an additional 6 years working in industry with clinical trial experience. I am on the Editorial Board for Laboratory Medicine and Advance for Administrators of the Laboratory. Additionally, my involvement with ASCP has put me on the Workshop committee, Board of Registry and currently I serve as co-chair of the Editorial Board. I am also on the executive committee of NASCOLA (North American Specialized Coagulation Laboratories Association). I am a member of the CLSI guidelines committee: Hematology Area and worked on the CLSI Lupus Anticoagulant 2010-2014 and chair the CLSI Factor Assay document.


    The thrombin time assay is a versatile clinical assay used for screening fibrinogen related disorders and quantification of fibrin degradation products, as well as for detecting the presence of anticoagulant drugs.  In situations where other screening tests may not be used to reliably diagnose fibrinogen related disorders, use of the thrombin time to discriminate these disorders may be the most effective choice.  With new classes of direct oral anticoagulants in clinical use, interest in the thrombin time has increased.  The purpose of this program is to describe the methodology and optimal use of the thrombin time assay for regular use in the clinical laboratory.  Case studies highlighting the various applications of the thrombin time will also be presented.

    • Describe the mechanism of the Thrombin Time assay.
    • Identify how to optimize utilization of the Thrombin Time in the laboratory.
    • Analyze results to enhance problem solving.

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