MAR 18, 2015 7:30 AM PDT

Special Lecturer - Circuits of Reward/Motivation and Decisions: Linking Connectivity to Function and Disease

Presented at: Neuroscience
Speaker
  • Professor, Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry
    Biography
      Dr. Habers research focuses on the neural network underlying learning and decision-making that leads to action plan development. The cortico-basal ganglia-thalamic system is central to this network and comprises a diverse group of structures involved in reward and motivation, cognition and motor control. Pathology of this network is implicated in several mental health disorders including drug addiction, obsessive-compulsive disorder, and schizophrenia. Her lab is addressing the hypothesis that cortico-basal ganglia connections are critical for integrating information across functional domains. The lab is also investigating which pathways are stimulated during deep brain stimulation, a therapy now being actively investigated for depression and obsessive-compulsive disorder and understanding postnatal changes in the cortico-basal ganglia system associated with specific developmental milestones and the high level of plasticity during early learning.
      <br />
      <br />Dr. Haber received her Ph.D. in neuro-and bio-behavioral sciences from Stanford University.
      <br />

    Abstract

    The dorsal anterior cingulate cortex (dACC), orbitofrontal cortex (OFC), ventrolateral and ventromedial prefrontal cortex (vlPFC, vmPFC) and their connections with the basal ganglia play a central role in reward and decision-making. These areas, along with their white matter pathways, are closely associated with several psychiatric disorders, including depression, obsessive–compulsive disorder (OCD), and addiction. While their connections define the reward-related cortical and basal ganglia regions, their terminals also interface in specific locations with those from cognitive control cortical areas. These regions, specifically located in the dACC, vlPFC, and striatum, are in pivotal positions for providing a ‘platform’ for bottom-up and/or top down control of goal directed behaviors. The first part of this talk will address the connectivity of the reward circuit and its interface with cognitive control cortical regions. Axons from reward-related and cognitive control cortical areas travel through several white matter bundles, that shows changes in volume and diffusivity in several psychiatric disorders. Importantly, these WM bundles are targets for invasive surgeries for treatment of depression and OCD, including lesions and deep brain stimulation (DBS). For example, anterior capsulotomy and DBS, two surgical treatments for OCD and depression, target the internal capsule. Lesions of the dorsal cingulum bundle (cingulotomy), is also a target for depression and OCD, and the subgenual cingulum bundle is a DBS target for depression. The second part of this talk will demonstrate the PFC fiber positions through these bundles demonstrating the likely connections captured at the three surgical targets.


    Show Resources
    You May Also Like
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    C.E. CREDITS
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    NOV 10, 2020 7:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    NOV 10, 2020 7:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
    OCT 29, 2020 6:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    AUG 18, 2020 10:00 AM PDT
    C.E. CREDITS
    AUG 18, 2020 10:00 AM PDT
    DATE: August 18, 2020 TIME: 10:00am PT Get deeper understanding of gene expression patterns by using assays that retain spatial organization at single cell resolution! Come learn about the n...
    Loading Comments...
    Show Resources