MAR 18, 2015 10:30 AM PDT

Special Lecturer - Oxidative Stress in Schizophrenia: a Translational Approach

Presented at: Neuroscience
Speaker

Abstract

Schizophrenia is a severe psychiatric disorder affecting 1% of the world’s population, leading to high human, social and economic burdens. Understanding how the interaction of gene and environment risk factors during neurodevelopment leads to cognitive, affective and social impairment is a central challenge in schizophrenia pathophysiology. I will discuss how these risk factors converge on a hub composed of NMDA-receptor hypofunction, neuroinflammation and redox imbalance/oxidative stress, leading to structural and functional dysconnectivity. Based on oxidative stress markers and genetic associations in patients, this hypothesis received support from a glutathione deficit preclinical model (gclm -/-mice), reproducing numerous schizophrenia phenotypes including NMDA receptor hypofunction, inflammation, impaired parvalbumine fast-spiking GABA interneurons (PVI), myelination, neural synchronization and behavioral anomalies. This model also highlights childhood and peripuberty as critical periods of high vulnerability for environmental adverse insults. Indeed, additional oxidative challenges in juvenile and peripubertal ages, but not in adult gclm-/- mice, lead to severe and permanent PVI impairment. Regulation of redox state in PVI also balances plasticity and stability across cortical development, through delaying and/or keeping critical periods of plasticity open-ended. Moreover, long range connections may also be affected by redox dysregulation during development: gclm-/- mice present myelin marker deficits in the prefrontal cortex at peripuberty, involving the Fyn kinase pathway dysregulation, which lead to decreased oligodendrocyte proliferation. Most importantly, the antioxidant and GSH precursor N-acetyl-cysteine (NAC), prevents the morphological, biochemical, physiological and behavioral alterations described above. A translational approach towards prevention attempts to modify the disease course by redox modulators will be presented.


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
MAR 18, 2015 10:30 AM PDT

Special Lecturer - Oxidative Stress in Schizophrenia: a Translational Approach

Presented at: Neuroscience

Specialty

Oncology

Research

Neuroscience

Research And Development

Animal Behavior

Chemistry

Genomics

Animal Research

Cell Biology

Gene Sequencing

Systems Biology

University

Cancer Diagnostics

Dna Sequencing

General Medicine

Geography

Asia50%

Europe50%

Registration Source

Website Visitors100%

Job Title

Medical Doctor/Specialist50%

Educator/Faculty25%

Medical Laboratory Technician25%

Organization

Academic Institution25%

Consultant25%

Hospital25%

Manufacturer - Other25%


Show Resources
Loading Comments...
Show Resources