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NOV 05, 2020 7:00 AM PST
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Stem cell derived exosome production in stirred-tank bioreactors

Sponsored by: Eppendorf
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Senior Research Scientist in the Applications Lab of Eppendorf, Inc.
    Biography

      Jorge Escobar is a senior research scientist in the applications lab of Eppendorf, Inc., in Enfield, Connecticut, USA. He joined the company in 2019 and has worked on applied research focused on efficient expansion of adherent and non-adherent cells (e.g. stem cells, adult primary cells) in cell culture bioreactors. After his Ph.D. in Biomedical Engineering at the Polytechnic University of Valencia (UPV), he gained experience in the fields of cell therapy and regenerative medicine working as a researcher at the Center for Biomaterials and Tissue Engineering (UPV, Valencia, Spain), Institute of Biomaterial Sciences - Helmholtz-Zentrum Geesthacht (Berlin, Germany) and Institute for Regenerative Engineering (University of Connecticut Health, Connecticut, USA). Additionally, in 2017, he was promoted to Assistant Research Professor, Department of Chemical and Biomolecular Engineering, University of Connecticut.

    • Project Manager and Application Specialist for Eppendorf Application Technologies
      Biography

        After a PhD in cell biology obtained at the uNamur, Belgium, and more than 10 years in the academic field, Aurélie Tacheny is now working for 6 years as Project Manager and Application Specialist for Eppendorf Application Technologies. Responsible for various cell culture-related projects, Aurélie and her team in the lab, use her expertise in this field to generate valuable experimental data and support current and future Eppendorf products and customers.


      Abstract

      DATE:  November 5, 2020

      TIME:   7am PST, 10am EST, 4pm CET

       

      Exosomes are a population of naturally occurring mobile, membrane-limited, 30 – 100 nm in diameter, extracellular vesicles containing a large number of proteins, lipids, messenger, and micro-RNAs. It was shown that they play a role in the mediation of intercellular communication, the modulation of immune-regulatory processes, tumor metabolism, and regenerative as well as degenerative processes. In recent years, there is increasing interest in the therapeutic potential of exosomes produced by Mesenchymal Stem Cells (MSCs).

      Stirred-tank bioreactors offer the possibility to tightly control and monitor the production of exosomes, as well as the scalability, to produce increasing amounts. However, the cultivation of stem cells in stirred-tank bioreactors requires profound knowledge and precise control of the process.

      In our talk, we will highlight the potential and benefits of stirred-tank bioreactors in the cultivation of stem cells for exosome production. We will share our knowledge on how we developed the process in our DASbox® Mini Parallel Bioreactor System and scaled-up the process to 1 L controlled by our newest parallel bioreactor control system, the SciVario® twin.

      Target groups:

      · Scientists new to the cultivation of stem cells in bioreactors

      · Experienced scientists looking for tips and tricks to improve their stem cell culture and EV production processes

       

      Learning Objectives:

      1. How to cultivate stem cells in a stirred-tank bioreactor: Learn how to identify the right cultivation method, vessel type, vessel material, and instrument configuration for your specific needs
      2. Learn how to define and optimize important parameters to improve culture results – incl. Tips & Tricks
      3. Live “Ask the Expert” session – Deepen your knowledge and optimize your process

       

      This webinar is part of a virtual event. With attending the live webinar you will also have access to the Eppendorf Planet of Knowledge Platform on which more engaging and educational content about stem cell bioprocessing will be provided.

       

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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