Assistant Professor of Biopharmaceutical Sciences, Keck Graduate Institute School of Pharmacy
BIOGRAPHY
MAR 14, 2018 6:00 AM PDT
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Targeting the Blood-Brain Barrier Transferrin Receptor for Delivery of Biologics for Alzheimer's Disease
Presented at:
Neuroscience 2018
Speaker
Abstract
98% of small molecules and 100% of large molecules do not cross the blood-brain barrier (BBB). Biologics, including therapeutic antibodies (e.g. anti-amyloid antibodies), have been at the forefront of Alzheimer’s disease (AD) research, however have had limited success so far. Biologics are large molecules with limited permeability across the BBB, and in the absence of a BBB-targeting approach to deliver these biologics to the brain, the true potential of the biologic cannot be determined. One approach to deliver a biologic, including anti-amyloid antibodies, decoy receptors and neurotrophins, for AD is to engineer bispecific fusion proteins, such that one domain of the fusion protein is the therapeutic biologic of interest, and the other domain acts as a molecular Trojan horse to ferry the biologic into the brain. This talk will focus on some of our work involving the targeting of the BBB transferrin receptor to deliver biologics (e.g. anti-amyloid antibody and biologic TNF-a inhibitor) in mouse models of AD.
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MAR 14, 2018 6:00 AM PDT
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Targeting the Blood-Brain Barrier Transferrin Receptor for Delivery of Biologics for Alzheimer's Disease
Presented at:
Neuroscience 2018
Specialty
Immunology
Cancer Research
Cancer Diagnostics
Dna Sequencing
Biomarkers
Health
Clinical Research
Laboratory Testing
Protein
Assay Development
Brain
Cell Culture
Gene Therapy
Research And Development
Pcr/rt-Pcr/real-Time Pcr
Geography
Asia50%
Europe25%
Africa25%
Registration Source
Website Visitors100%
Job Title
Student50%
Educator/Faculty25%
Medical Laboratory Technician25%
Organization
Academic Institution50%
Hospital25%
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