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JUN 20, 2019 12:00 PM PDT

Tissue and cfDNA Rare Alleles: How Low Can We Go?

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Director Scientific Collaboration , Department of Genetics, Washington University School of Medicine
    Biography
      Seth Crosby is the Director of Science Collaboration in the Department of Genetics at Washington University. Crosby works with groups within and outside the University to leverage technology to achieve research and clinical goals. He has been at Washington University for 16 years. During that time, he directed the Department of Genetics Microarray Core, which is now part of GTAC and then GTAC, itself, during its first two years. Prior to that he was the Director of Translational Research at the Genome Center (now the McDonnell Genome Institute). Prior to his tenure at Washington University, Dr. Crosby worked in the field of genomics and drug discovery at Abbott Laboratories, Pfizer and Pharmacia.

    Abstract

    This talk will review successful efforts at Washington University to employ novel reagents and informatics to the problem of rare allele detection. I will discuss a published bakeoff of in silico variant callers. I will describe rare variant detection in our lab using a novel “unlockable” blocked PCR primer developed at IDT. Finally I will describe a new method, developed at Washington University to leverage UMI to push detection down to 1 in 10,000.

    Learning Objectives: 

    1. Will discuss bench versus bioinformatic approaches to sensitivity to rare alleles both in malignant tissue and in a so-called ”liquid biopsy".
    2. Will discuss the method that proports maximum sensitivity (0.01)


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    Tissue and cfDNA Rare Alleles: How Low Can We Go?

    C.E. Credits: P.A.C.E. CE Florida CE

    Specialty

    Gene Expression

    Cancer Diagnostics

    Biomarkers

    Cancer Research

    Clinical Diagnostics

    Genomics

    Gene Sequencing

    Oncology

    Diagnostics

    Molecular Biology

    Clinical Research

    Immunology

    Cell Culture

    Pcr/rt-Pcr/real-Time Pcr

    Dna

    Geography

    North America50%

    Asia33%

    Europe17%

    Registration Source

    Website Visitors100%

    Job Title

    Educator/Faculty40%

    Student20%

    Executive20%

    Research Scientist20%

    Organization

    Academic Institution50%

    Clinical Laboratory17%

    Research Institute17%

    Other17%


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