OCT 10, 2019 12:00 PM PDT

Tumor Mutation Burden: Challenges and opportunities of measuring and interpreting tumor mutational burden for patient care

Sponsored by: QIAGEN
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, Pathology; Associate Director, Residency Program; Medical Director, Cytogenetics Laboratory AUMC.
    Biography
      Currently, Dr.Ravindra Kolhe is an Associate Professor in the Department of Pathology at the Augusta University in Augusta, Georgia, and divides his time between directing Molecular Pathology, Cytogenetics, Breast Pathology, teaching, and research. He is the CLIA laboratory director for the Georgia Esoteric & Molecular Labs and also serves as the Medical Director for the Cytogenetics Laboratory. As a Molecular and Genetic Pathologist, he is actively engaged in molecular and cytogenetic evaluation of patient samples as a part of the multi- disciplinary clinical team treating patients in a personalized and precision medicine model. As a Breast Pathologist, he provides expert opinions for the breast multidisciplinary tumor boards, consultation and second opinion to difficult breast cancer patients referred to Georgia Cancer Center. Dr. Kolhe is an physician-scientist with expertise in basic mechanisms of tumor immunology, including tolerogenic DCs, Tregs, and the indoleamine 2,3-dioxygenase pathway He has over 160 publications, including peer-reviewed articles, abstracts and invited reviews most in the realm of the molecular pathology of various malignancies.

    Abstract

    Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation load increases the likelihood that immunogenic neoantigens expressed by tumor cells may induce a response to immunotherapy.  However, TMB estimation and reporting can be heavily influenced by differing working processes across clinical and research laboratories; primarily, the choice of assay, platform, and how the assay is implemented and interpreted. To streamline and standardize this process at scale, QIAGEN offers an end to end solution, from detection to interpretation of TMB and other somatic alterations.

    In this webinar, we will provide insights into the implementation of the QIAseq Tumor Mutational Burden (TMB) Panel in the molecular diagnostics lab. This comprehensive cancer panel is capable of interrogating TMB, microsatellite instability (MSI), and other actionable alterations in a single assay, using specialized chemistry to remove false positives. Subsequently, we will discuss how QIAGEN Clinical Insight Interpret can streamline insights from comprehensive cancer profiles to deliver actionable information on detected variants and immunotherapy biomarkers, such as tumor mutational burden (TMB) and microsatellite instability (MSI). We will also discuss the concordance of the automatic implementation of the AMP/ASCO/CAP guidelines with manual expert classifications.


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