DEC 01, 2016 08:00 AM PST

In Vivo Imaging Toolkit: Advancing Preclinical and Translational Science in Molecular and Orthopedic Research at UCLA

  • Chief, Division of Musculoskeletal Oncology Director, UCLA Global Orthopaedic Initiative, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA
      Dr. Bernthal is an orthopaedic oncologist who has been on the UCLA faculty since 2013. He graduated magna cum laude and phi beta kappa from Princeton University and received alpha omega alpha honors from Cornell University Medical School. He did his residency at UCLA in orthopaedic surgery and did fellowships in orthopaedic research and musculoskeletal oncology at UCLA and the Huntsman Cancer Institute, respectively. His clinical interests are bone and soft tissue tumors and his laboratory is pioneering new implant coatings to prevent surgical infections.
    • Director, Preclinical Imaging Technology Center, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology (DMMP), David Geffen School of Medicine at UCLA
        Dr. Lee received his Ph.D. in DMMP under Dr. Caius Radu and his postdoctoral training in molecular imaging at Memorial Sloan Kettering Cancer Center under Dr. Vladimir Ponomarev. His work focuses on the development and integration of in vivo imaging assays to quantitatively assess the functional dynamics of health and disease, and to study associated therapeutic interventions in preclinical models.

      DATE: December 1, 2016
      TIME:  8:00 AM PT, 11:00 AM ET

      Preclinical imaging enables the measurement and assessment of biological processes in vivo utilizing technologies such as bioluminescence, fluorescence and positron emission tomography (PET) platforms to assay cells, tissues, and living organisms. PerkinElmer’s suite of optical and PET scanners set the industry standard for sensitivity, quantitative accuracy, and data reproducibility. This enables premier research institutions like UCLA the opportunity to advance preclinical and translational science while fostering collaboration among imaging laboratories both internally and externally. In this institutional highlight webinar series, we are excited to share insight on how a successful imaging program at UCLA has been instrumental in generating novel models of disease and conducting cutting edge research.
      You will hear from Dr. Jason Lee, Director of the Preclinical Imaging Technology Center, Crump Institute for Molecular Imaging, who will highlight imaging technologies available for preclinical research and their applications in biomedical and translational studies at the Crump Institute and at UCLA. He will be followed by Dr. Nick Bernthal, Chief, Division of Musculoskeletal Oncology and Director, UCLA Global Orthopaedic Initiative, who will present collaborative work between groups at UCLA, Johns Hopkins, and USC who developed and examined a preclinical model of posterior-approach spinal surgery. Employing several imaging modalities, these studies demonstrate a successful model for noninvasive, in vivo examination of spine implant infection where both bacterial burden and host inflammation can be monitored longitudinally in real-time without requiring animal sacrifice.
      Join us to learn how successful research institutions are using in vivo imaging to aid their ongoing preclinical and translational research programs.  Doctors Lee and Bernthal will be happy to answer your questions following the presentation.

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