FEB 04, 2016 6:00 AM PST

Zebrafish: an upswing model in research and the need for refinement of anaesthesia

Speaker

Abstract

     In the last decade the number of publications in zebrafish tripled, from 938 in 2005 to 2432 in 2015 (Pubmed database; keyword: “zebrafish” in Title/Abstract; 12/4/2015), being the animal model with the highest increase in publication. These numbers reflect the importance of zebrafish as a good practical and scientific model for several human diseases, drug discovery and gene function identification through behavioural phenomics and high-throughput genetic and molecular screening.

     Zebrafish is legally protected by the European Directive on the protection of animals used for scientific purposes (2010/63/EU) when they become capable of independent feeding.
     
     However, the increasing use of zebrafish has not been accompanied by the evolution of anaesthetic protocols suitable for different experimental situations. Ethyl 3-aminobenzoate methanesulfate (MS222) is the standard fish anaesthetic, but concerns have been raised concerning aversion/ stress induction and cardiovascular depression in long procedures. This lecture intends to provide a review of the anaesthetics used in zebrafish in different contexts and the proposal of new anaesthetic protocols. The drugs’ availability, preparation, clinical efficacy and safety, and animal welfare issues will be discussed.

     There are legal, scientific and animal welfare reasons to study procedures’ refinement in zebrafish. This animal model needs proper research in the area of laboratory animal science for a better care and scientific quality.


Show Resources
You May Also Like
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
APR 28, 2022 8:00 AM PDT
APR 28, 2022 8:00 AM PDT
Date: April 28, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Human pluripotent stem cells (PSCs) and their derivatives hold great potentials in...
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
APR 26, 2022 7:00 AM PDT
C.E. CREDITS
APR 26, 2022 7:00 AM PDT
Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
FEB 04, 2016 6:00 AM PST

Zebrafish: an upswing model in research and the need for refinement of anaesthesia



Show Resources
Loading Comments...
Show Resources