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Learning Objectives: 1. Explain what is gene therapy is. 2. Explain what steps are involved for getting a gene therapy product to the clinic. 3. Discuss development and manufacturing process...
CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
It is commonly recognized that technicians are the backbone of a successful animal research program. Unfortunately, the invisible contributions that they make as well as the valuable high lev...
The use of pluripotent stem cells is dramatically altering the R&D landscape, providing new insights into both the basic biology of disease progression and novel cell types for pharmaceut...
G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named t...
Learning Objectives: 1. Participants will understand how cannabis works with the Endocannabinoid system and what is the Endocannabinoid system 2. Participants will understand how cannabis is...
Webinar airing too early or too late for you? This webinar will also be available: September 13 at 10:00am PDT, 1:00pm EDT https://www.labroots.com/ms/webinar/dpcr-liquidbiopsy-panel-2 and S...
Gene expression studies give a snapshot of the different types of RNAs being expressed at a given time point in cells or tissues in vivo. Different RNA types have different roles, for example...
We developed two computational methods, CARE and TIDE, to predict response and resistance to targeted therapies and immunotherapies. CARE infers gene signatures of targeted therapy response b...
Myeloid leukemias encompass a group of different diseases that include myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). These diseases are d...
Standards setting is an important process for improving forensic science. Guidelines, minimum practice and best standards all have their place in forensic toxicology. This lecture will focus...
Novel psychoactive substances (NPS) emerged in the United States around 2000. Initially, synthetic cannabinoids and stimulants prevailed. Now, designer opioids, benzodiazepines an...
Neurological disorders present a worldwide multi-factorial burden. They affect as many as one billion people globally - and that number is predicted to increase in the next decades. The wide-...
Join Dr Ann Wheeler of Queen Mary University as she reviews the basic principles of confocal microscopy, including: Sample preparation for confocal microscopy</li><li>When y...
Detection of mutational alterations is important for guiding treatment decisions of lung non-small cell carcinomas and thyroid nodules with atypical cytologic findings. Inoperable lung tumors...
Medical providers now have a number of new technologies available for the rapid diagnosis of strep pharyngitis. Dr. Schuman will present an overview of strep pharyngitis, signs and symptoms a...
Stem cells play critical roles in the development of organisms, as well as in the maintenance and repair of organs and tissues throughout adulthood. Advancing our understanding of mecha...
Potency is a critical quality attribute of biological products, defined by the US FDA as the specific ability of the product to cause the required therapeutically clinical benefit. Potency a...
Radicle Science's ACES (Advancing CBD Education & Science) study was an IRB approved 4 week, 14 arm, open label randomized clinical trial of 13 CBD products plus a waitlist control g...
The ExpiCHO transient expression system allows for the high titer production of a broad range of recombinant proteins. Due to the high titers observed for many proteins in the ExpiCHO system,...
Imaging-based techniques have traditionally been restricted to the diagnosis and staging of cancer. But technological advances are moving imaging modalities into the heart of patient care. Im...
Interesting case presentations on Genitourinary cancers with focus in prostate and bladder cancers will be discussed during this event. Learning objectives: The objective of this Labtalk is...
Cell line development (CLD) is often a critical bottleneck in biopharmaceutical production, often requiring labor-intensive workflows and multiple sequential screening steps that extend time...
I will present our new computer vision algorithm, ST-Net, which can computationally synthesize spatially resolved transcriptomics directly from H&E histology images (He et al. Nature Bio...
In biomedical research, data should be treated as first-class corporate assets--they were expensive to create, they are expensive to maintain, and they have future business value. The petabyt...
This seminar will cover spontaneous diseases of Rhesus Macaques utilizing a systemic approach. It will consist of gross and histopathologic images of common pathologic conditions highlighting...
What does a quantum leap in drug development look like and what is necessary to make it happen? Our greatest opportunity to deliver significant increases in the speed and effectiveness of dr...