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Numerous biomedical applications have been described for liver-humanized mouse models, such as in drug metabolism or drug-drug interaction (DDI) studies. However, the strong enlargement of t...
Efficient utilisation of abundant renewable sugars and aromatic chemicals by natural or recombinant microorganisms is a key prerequisite for the economic viability of biotechnological valori...
Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mese...
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 9:40am PST-10:05am PST Presented by: Stephanie Samra According to the National Forensics Laborat...
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We present programmable ad...
The ability to record every spike from every neuron in a behaving animal is one of the holy grails of neuroscience. Here, Alison Hanson discusses a collaborative effort aimed at coming one s...
Worker safety is a critical component of compliance as well as sustaining a healthy and safe work environment. This became more evident than ever during......
The evolution of the planetary situation is presently knowing multiple rapid and severe complications impacting both geophysical as well as all the life aspects. Multiple parameters undergo...
2020 started as a year of inspired regulatory improvements to increase the safety and quality of food in the US. Due to recent pandemic effects, the expected regulatory trends have evolved....
Chimeric antigen receptor (CAR) T-cell therapy shows significant potential in treating various human cancers. Unfortunately, researchers have faced difficulty in adapting this therapy to tar...
Effective locomotion in nature happens by transitioning between multiple modes (e.g., walk, run, climb, slither). Despite this, far more mechanistic understanding of terrestrial locomotion h...
Throughout history, various approaches including surgery, radiation therapy, chemotherapy, and targeted therapy have been employed in the fight against cancer. In the 2010s, the emergence of...
Learning Objectives 1) Examine the importance of mechanical forces in cellular activities. 2) Evaluate current strategies for force measurement at the cellular and molecular level. 3) Elucid...
The 21st century brought with it an unprecedented number of global and regional economic and political crises, giving rise to a new generation of conflicts in which novel technological, biol...
Studying motor behaviors can reveal fundamental principles of the brain and mind. This presentation focuses on our work towards developing the hardware and computational tools that will allo...
Antibiotic treatment failure poses a burden on global public health systems. Bacteria can acquire mutations and extrachromosomal genes that allow them to be resistant to our existing drugs....
The study of psychopathology is changing with the advent and pervasive use of smartphones, wearables, and connected devices together with significant advances in brain imaging. These new ave...
NAFLD (non-alcoholic fatty liver disease) is a global epidemic that affects 25% of the world’s population, with its epicentre in the West. Twenty percent of NAFLD patients go on to dev...
Infrared spectroscopy and microscopy directly couples to molecular functional groups, providing chemical information without extrinsic labels. However, conventional infrared spectroscopy and...
Cancer is a group of complex genomic diseases. Today still most clinicians, patients ans policymakers think that precision oncology is the sequencing of cancer genomes, which is for many pati...
The Molecular Twin is a proof-of-principle platform that combines data from several clinical and molecular analytes from both tumor and host and applies AI and machine learning approaches to...
Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
Measurable or minimal residual disease (MRD) is the presence of very small numbers of tumor cells which may remain in the body following treatment. MRD testing currently has multiple clinica...
Many experimental approaches rely on controlling gene expression in select subsets of cells within an individual animal. However, reproducibly targeting transgene expression to specific frac...
Learning Objectives: 1. Delivery vehicles for the Cas9 RNP 2. Gene editing after a direct tissue injection 3. New linkers for conjugating proteins to polymers...
Numerous biomedical applications have been described for liver-humanized mouse models, such as in drug metabolism or drug-drug interaction (DDI) studies. However, the strong enlargement of t...
