The Pain Targeted Venom Discovery Array (T-VDA) is specifically designed to maximise discovery of new analgesic tools. Ion channels are very important pain targets along with receptors such as opioids and acetylcholine. Venoms from theraphosids (tarantulas), scorpions and snakes are rich sources of new analgesic tools. These targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Each array contains characterised venoms active in analgesic pathways from the literature to act as positive controls. The control venoms for T-VDA pain include Thrixopelma puriens (Peruvian velvet tarantula) where Protox II, a gating modifier of NaV1.7 [1], was discovered; Leiurus quinquestriatus (death stalker scorpion) where opioid selective tools have been discovered [2]; and Dendroaspis polylepis (black mamba) venom which contain mambalgins [3] - potent and selective ASIC channel tools. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.

• Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.

• 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.

• 1536-well format also available.