The Cytotoxic Targeted Venom Discovery Array is specifically designed to maximise discovery of new tools. Cytotoxins are important drug tools for a range of applications including oncology and cellular mechanisms. Venoms from snakes (vipers and elapids) as well as scorpions are rich sources of new cytotoxins with various mechanisms. These targeted arrays contain pure venom fractions from 12, 24, 48 or 96 species optimised for identification of novel tools. Every array contains characterised venoms with cytotoxic activity from the literature to act as positive controls. The control venoms for T- VDActox include Naja nigricollis (black-necked spitting cobra) which contains three finger toxins [1]; Crotalus ruber (red diamondback rattlesnake) where the cytotoxic activity is from multiple enzymatic mechanisms [2]; and Scorpio maurus (Israeli gold scorpion) which also contains a diverse collection of cytotoxic peptides [3]. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximise novel hit potential.

• Venoms are supplied lyophilised in Echo qualified acoustic source plates (Labcyte Inc) and are useable on any SBS footprint liquid handling device or by hand.

• 384-well format has 200ng venom fraction per well, suggested dilution 20µl as hit fractions are typically active at 5µg/ml and below.

• 1536-well format also available.