mouse monoclonal IgG2b; BMP-4 Antibody (3H2.3) is an IgG2b κ mouse monoclonal BMP-4 antibody that detects presursor and mature BMP-4 of mouse, rat and human origin by WB, IP and IF. BMP-4 Antibody (3H2.3) is available as the non-conjugated anti-BMP-4 antibody form, as well as multiple conjugated forms of anti-BMP-4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Bone morphogenic proteins (BMPs) are members of the TGFβ superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGFβ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.