hamster monoclonal IgG; TNFα Antibody (TN3-19.12) is an IgG Armenian hamster monoclonal TNF alpha antibody (also designated TNF alpha antibody or TNFA antibody) that detects the TNF alpha protein of m, r, rabbit origin by WB, IP and IF. TNFα Antibody (TN3-19.12) is available as both the non-conjugated anti-TNF alpha antibody form, as well as multiple conjugated forms of anti-TNF alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachectin, is a smaller cytokine that binds to the same receptors, producing a vast array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, which include lymphocytes, neutrophils and macrophages. TNFα and TNFβ can modulate many immune and inflammatory functions, while having the ability to inhibit tumor growth. Target tumor cells must express TNF receptors 1 and 2 to be killed, with the p55 receptor mediating the cytotoxic response.