rat monoclonal IgG2a; RP105 Antibody (RP/14) is an IgG2a rat monoclonal RP105 antibody (also designated RP105 antibody) that detects the RP105 protein of mouse origin by IP, IF, FCM and ELISA. RP105 Antibody (RP/14) is available as both the non-conjugated anti-RP105 antibody form, as well as multiple conjugated forms of anti-RP105 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. RP105 is a mouse B-cell surface molecule that transmits a growth-promoting signal and is implicated in the life/death decision of B cells. RP105 has tandem repeats of a leucine-rich motif in its extracellular domain that are presumed to be involved in protein-protein interactions. The amino acid sequence of human RP105 is highly homologous to that of mouse RP105; human RP105 shares 74% identity with the mouse protein, as well as the leucine-rich motif. Surface expression of RP105 is enhanced in the presence of MD1, although this expression is restricted to CD19-positive B cells. RP105 demonstrates predominant expression on mature B cells in mantle zones; very little expression is observed in germinal centers.