mouse monoclonal IgG1; demethylated-PP2A-C Antibody (4B7) is an IgG1 κ mouse monoclonal demethylated-PP2A-C antibody (also designated demethylation specific Serine/Threonine phosphatase PP2A-C alpha/beta antibody, PP2CA antibody, PP2CB antibody, protein phosphatase 2 catalytic subunit C alpha/beta antibody, protein phosphatase 2 (PP2A) C alpha/beta antibody, PPP2CA protein phosphatase 2 catalytic subunit alpha/beta antibody, PP2A heterotrimeric (structural A, regulatory B, catalytic C) protein phosphatase antibody, PP2A phosphatase catalytic C alpha/beta antibody, protein phosphatase 2 complex antibody, or Ser/Thr phosphatase methylation state antibody) that detects the demethylated-PP2A-C protein of mouse, rat, human and d, x, S. pombe origin by WB, IP, IF and IHC(P). demethylated-PP2A-C Antibody (4B7) is available as both the non-conjugated anti-demethylated-PP2A-C antibody form, as well as multiple conjugated forms of anti-demethylated-PP2A-C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A catalytic subunit is a protein that associates with a variety of regulatory subunits. Regulatory subunits include PP2A-Aa and -Ab, PP2A-Ba and -Bb, PP2A-Ca and -Cb, PP2A-B56a and -B56b.