mouse monoclonal IgG2b; SOD-1 Antibody (G-11) is an IgG2b κ mouse monoclonal SOD-1 antibody (also designated SOD1 antibody, superoxide dismutase 1 antibody) that detects the SOD-1 protein of human origin by WB, IP, IF, IHC(P) and ELISA. SOD-1 Antibody (G-11) is available as both the non-conjugated anti-SOD-1 antibody form, as well as multiple conjugated forms of anti-SOD-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer's disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.