mouse monoclonal IgG2b; TGFβ Receptor II/TGFBR2 Antibody (D-2) is an IgG2b κ mouse monoclonal TGFβ RII antibody (also designated TGFβ RII antibody) that detects TGFβ RII of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. TGFβ Receptor II/TGFBR2 Antibody (D-2) is available as the non-conjugated anti-TGFβ RII antibody form, as well as multiple conjugated forms of anti-TGFβ RII antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor (TGFβ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGFβ RII (TGF-beta receptor type-2), also known as TGFBR2, is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain and is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. For signaling growth inhibition and early gene responses, TGFβ RII requires both its kinase activity and association with a TGFβ-binding protein, designated the type I receptor. TGFβ RII exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 3.