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Santa Cruz Biotechnology

karyopherin β3 (E-4) | Santa Cruz Biotechnology

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mouse monoclonal IgG2a; Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin α1 and karyopherin β1 subunits. Karyopherin α1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin β1 serves as an adapter, tethering the karyopherin α1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin α2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Certain RNA-binding proteins are imported to the nucleus by karyopherin β2, and karyopherin β3 appears to be involved in the import of some ribosomal proteins.

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Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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