Santa Cruz Biotechnology

TAT (D-9) | Santa Cruz Biotechnology

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mouse monoclonal IgG1; TAT (tyrosine aminotransferase) is a 454 amino acid protein that localizes to mitochondria and belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Existing as a homodimer, TAT uses pyridoxal phosphate as a cofactor to catalyze the conversion of L-tyrosine into p-hydroxyphenylpyruvate, a reaction that is important in amino acid degradation. Defects in the gene encoding TAT are the cause of tyrosinemia type 2 (TYRO2), an inborn error of metabolism that is associated with elevated levels of tyrosine in blood and urine and is characterized by palmoplantar keratosis, painful corneal ulcers and mental retardation. The gene encoding TAT maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.

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Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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