mouse monoclonal IgG1; SHIP-1 Antibody (P1C1) is an IgG1 κ mouse monoclonal SHIP-1 antibody(also designated INPP5D antibody, or SHIP1 antibody) that detects the SHIP-1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. SHIP-1 Antibody (P1C1) is available as both the non-conjugated anti-SHIP-1 antibody form, as well as multiple conjugated forms of anti-SHIP-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.