Compound screening in an important step in the drug discovery pipeline. Performed in a laboratory setting, compound screening identifies compounds in small molecules that have a beneficial biological impact. Once identified, compounds are held in libraries containing information and details in a searchable formal.
Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ ï€ 4-(4-(dimethylamino)styryl)-N-methylpyridi...
Date: October 04, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) The ability to derive induced pluripotent stem cells (iPSCs) from differentiated cell types such as fibroblasts, has r...
The gastrointestinal (GI) epithelium is the body’s first line of defense to luminal contents such as food, microbiota, pharmaceuticals, and toxins. A small pool of proliferative stem a...
Date: August 18, 2022 Time: 3pm AEST | 1pm SGT | 2pm JP/KR Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors...
High-throughput screening (HTS) is crucial to generate hits and leads in drug discovery efforts. Most high-throughput biochemical assays are based on optical detection or radioactivity with...
Current drug discovery workflows rely on the synthesis and bioactivity assessment of large compound libraries, both processes which heavily depend on high-throughput (HT) experimentation to...
Learning Objectives: 1. Understand the Analytical Quality by Design Principles 2. Learn about the benefits of using specialized software for rapid and robust method development....
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 9:40am PST-10:05am PST Presented by: Stephanie Samra According to the National Forensics Laborat...
Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. In the here presented case stud...
The increase in the number and diversity of drugs of abuse is a major concern; it also presents significant challenges for forensic laboratories who are involved in the analysis of seized su...
Date: March 11, 2021 Time: 8:00am (PST), 11:00am (EST) g the toxicity profile of a compound is a necessity across industries and the various stages of drug development. Early stage mechanism...
G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named t...
Traditional drug discovery often begins with simple biochemical and transformed cellular models, advances to more complex animal models in late discovery phases, and often does not ‘se...
Key to the development of the HUB Organoid Technology was the discovery of LGR5+ intestinal adult stem cells by the Clevers’ lab. With the identification of these stem cells, we were a...
This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
Organoid technologies are increasingly being used as in vitro models of human development and disease because they exhibit morphogenetic, structural and functional properties that recapitula...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
Organoids are three-dimensional (3D) multi-cellular, microtissues derived from stem cells that closely mimic the complex structure and functionality of human organs. They offer more accurate...
In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ ï€ 4-(4-(dimethylamino)styryl)-N-methylpyridi...
Date: October 04, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) The ability to derive induced pluripotent stem cells (iPSCs) from differentiated cell types such as fibroblasts, has r...
The gastrointestinal (GI) epithelium is the body’s first line of defense to luminal contents such as food, microbiota, pharmaceuticals, and toxins. A small pool of proliferative stem a...
Date: August 18, 2022 Time: 3pm AEST | 1pm SGT | 2pm JP/KR Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors...
High-throughput screening (HTS) is crucial to generate hits and leads in drug discovery efforts. Most high-throughput biochemical assays are based on optical detection or radioactivity with...
Current drug discovery workflows rely on the synthesis and bioactivity assessment of large compound libraries, both processes which heavily depend on high-throughput (HT) experimentation to...
Learning Objectives: 1. Understand the Analytical Quality by Design Principles 2. Learn about the benefits of using specialized software for rapid and robust method development....
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 9:40am PST-10:05am PST Presented by: Stephanie Samra According to the National Forensics Laborat...
Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. In the here presented case stud...
The increase in the number and diversity of drugs of abuse is a major concern; it also presents significant challenges for forensic laboratories who are involved in the analysis of seized su...
Date: March 11, 2021 Time: 8:00am (PST), 11:00am (EST) g the toxicity profile of a compound is a necessity across industries and the various stages of drug development. Early stage mechanism...
G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named t...
Traditional drug discovery often begins with simple biochemical and transformed cellular models, advances to more complex animal models in late discovery phases, and often does not ‘se...
Key to the development of the HUB Organoid Technology was the discovery of LGR5+ intestinal adult stem cells by the Clevers’ lab. With the identification of these stem cells, we were a...
This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
The pharmaceuticals and biotechnology industries have made substantial progress in reducing the number of drugs that fail in clinical trials due to safety. This has been due, in part, to an...
Solid phase extraction has become a preferable technique for reducing matrix effects for sample preparation due to its ease of use and limited time requirements. MilliporeSigma has launched...
Pesticides are routinely applied to crops to prevent or control pests and are therefore routinely tested for the presence of pesticide residues and to check for compliance with permitted Max...
There are an urgent need for antivirals to treat the newly emerged SARS-CoV-2. We set out to develop cell-based screens to repurpose existing drugs for use against SARS-CoV-2. Our goal was t...
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