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    Gene signatures

    Gene signatures describe specific, unique characteristics of a group of genes located in a biological cell or tissue. Gene signatures can be used to diagnose diseases, including cancer. Additionally, understanding gene signatures can inform on the prognosis of disease or determine optimal treatment planning.

    Webinars

    • DEC 07, 2023 | 8:00 AM
      Translating COSMIC's gold standard data into actionable insights
      Translating COSMIC's gold standard data into actionable insights
      As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
      Speaker: Leonie Hodges , Alex Holmes, Ph.D. , Jennifer Wilding, Ph.D.
      Sponsored By: QIAGEN
      15
      NOV 09, 2023 | 6:00 AM
      Using MERFISH to decode spatially regulated disease drivers in human heart and kidney disease
      Using MERFISH to decode spatially regulated disease drivers in...
      In this talk we will explore the application of Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology to decode spatially regulated disease drivers in human heart...
      Speaker: Christoph Kuppe, MD, MHBA
      Sponsored By: Vizgen
      8
      OCT 24, 2023 | 10:00 AM
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
      An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
      Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
      Speaker: Andrea Johnstone, Ph.D. , Lori Euler
      Sponsored By: Beckman Coulter Life Sciences
      30
      MAR 30, 2023 | 5:00 PM
      Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies
      Memory-rich CAR-T cell engineering by piggyBac transposon system...
      Date: March 30, 2023 Time: 5:00pm (PST), 8:00pm (EST) March 31, 2023 9:00am (JST) Chimeric antigen receptor T cell (CAR-T) therapy is still challenging in targeting solid malignancies. The q...
      Speaker: Dr. Shigeki Yagyu
      Sponsored By: MaxCyte®
      15
      MAR 01, 2023 | 8:00 AM
      Maximizing metastasis insights: Using a novel integrated workflow approach to achieve efficient CTC enrichment, enumeration and identification
      Maximizing metastasis insights: Using a novel integrated workflow...
      Date: March 01, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Characterizing metastasis remains key for understanding and eradicating cancer. The study of circulating tumor cells (CTC...
      Speaker: Adam Corner, Ph.D.
      Sponsored By: Bio-Rad Laboratories
      8
      OCT 19, 2022 | 1:30 PM
      A Phase 1 Trial of Cyclosporine for Hospitalized Patients with COVID-19
      A Phase 1 Trial of Cyclosporine for Hospitalized Patients with...
      COVID-19 remains a global health emergency with limited treatment options, lagging vaccine rates, and inadequate healthcare resources in the face of an ongoing calamity. The disease is chara...
      Speaker: Julia Han Noll, MS
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      6
      OCT 06, 2022 | 7:30 AM
      Single-Cell Analysis of the Tumor Microenvironment in High-Grade Serous Ovarian Carcinoma (HGSOC)
      Single-Cell Analysis of the Tumor Microenvironment in High-Grade...
      Single-cell RNA sequencing (scRNA-seq) is an important technology that reveals gene expression differences between different cell types. Yet scRNA-seq data can be challenging to analyze and...
      Speaker: Jean-Noel Billaud, PhD
      Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
      Sponsored By: QIAGEN
      5
      OCT 04, 2022 | 1:30 PM
      Genomic Biomarker for Predicting Response in Early Breast Cancer Patients
      Genomic Biomarker for Predicting Response in Early Breast Cancer...
      Human solid tumors, like breast cancers, represent a heterogeneous group of diseases that is best demonstrated through many differences in clinical outcomes within homogenously treated patie...
      Speaker: Maggie Cheang, Ph.D.
      Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      5
      OCT 04, 2022 | 7:30 AM
      The Invasive Niche of Basal Cell Carcinoma as Revealed by Integrated Multi-Omics with Live Q&A
      The Invasive Niche of Basal Cell Carcinoma as Revealed by Integrated...
      Tumors invade surrounding tissue as cancer progresses, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their interactions has hampered mechanistic ins...
      Speaker: Laura Yerly
      Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      3
      MAY 04, 2022 | 3:00 PM
      Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
      Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019...
      Speaker: Arutha Kulasinghe, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      6
      APR 21, 2022 | 5:30 AM
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
      Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
      A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
      Speaker: Joely Irlam
      Presented at: Genetics Week Virtual Event Series 2022
      2
      MAR 10, 2022 | 7:30 AM
      Spatial Transcriptomic Profiling of Spiny Projection Neurons in the Mouse Striatum
      Spatial Transcriptomic Profiling of Spiny Projection Neurons in...
      NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
      Speaker: Alison VanSchoiack, PhD
      Presented at: Neuroscience Virtual Event Series 2022
      Sponsored By: NanoString Technologies
      3
      MAR 09, 2022 | 8:00 AM
      Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
      Biosecurity for Genome Engineering: Safety First and the SeqScreen...
      Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
      Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
      Sponsored By: Inscripta
      5
      OCT 13, 2021 | 10:30 AM
      Spatial Transcriptomic Profiling of Severe COVID-19 Patients
      Spatial Transcriptomic Profiling of Severe COVID-19 Patients
      Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. In this study, we utiliz...
      Speaker: Camilla Margaroli, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      2
      MAY 05, 2021 | 12:00 AM
      Microbiomes after Death
      Microbiomes after Death
      The postmortem microbiome is an emerging field in forensic science with broad application for death investigation (e.g., time since death). While the foundation for forensic microbiology beg...
      Speaker: Jennifer Pechal, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      1
      APR 29, 2021 | 4:15 PM
      Comprehensive Genomic Profiling for Homologous Recombination Repair Deficiency (HRD) Assessment
      Comprehensive Genomic Profiling for Homologous Recombination Repair...
      Comprehensive genomic profiling (CGP) is advancing precision oncology research through simultaneous analysis of multiple biomarkers in a single next-generation sequencing (NGS) assay. In thi...
      Speaker: Dr. Andreas Jung
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      2
      APR 20, 2021 | 9:00 AM
      Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation and Contextualizes Alzheimer's Associated Polymorphisms
      Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation...
      Chromatin Immunoprecipitation, coupled with sequencing, has shaped our understanding of how transcriptional machinery interacts with genomes to facilitate gene regulation. These protein-DNA...
      Speaker: Cory Padilla, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: Dovetail Genomics
      1
      APR 20, 2021 | 12:00 AM
      Practical Considerations and Best Practices for Single Cell and Spatial Transcriptomics
      Practical Considerations and Best Practices for Single Cell and...
      Learning Obejctives: 1. Understand the key requirements for sample preparation in a single cell and/or spatial transcriptomics experiment 2. Learn the synergies between a combined single cel...
      Speaker: Neil Winegarden, MSc
      Presented at: Genetics Week Virtual Event Series 2021
      1
      APR 20, 2021 | 12:00 AM
      C.E. CREDITS
      Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure
      Telomere-to-Telomere Chromosome Assemblies: New Insights Into...
      We are entering into an exciting era of genomics where truly complete, high-quality assemblies of human chromosomes are available end-to-end, or from ‘telomere-to-telomere’ (T2T)...
      Speaker: Karen Miga, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      FEB 10, 2021 | 12:00 AM
      Organoids & Toxins - from snakebite to DNA-damaging bacteria
      Organoids & Toxins - from snakebite to DNA-damaging bacteria
      Organoids are emerging tools to study homeostatic function and disease of human organs. This technology has now for the first time been extended to reptiles by establishing cultures of the s...
      Speaker: Jens Puschhof
      Presented at: Laboratory Animal Sciences Virtual Event Series 2021
      2
      JAN 27, 2021 | 9:00 AM
      Uterine B cell dynamics during pregnancy - Immune regulation of the placenta
      Uterine B cell dynamics during pregnancy - Immune regulation of...
      DATE: January 27, 2021 TIME: 9am PST Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, as the uterine immune enviro...
      Speaker: Marilen Benner
      Sponsored By: Beckman Coulter Life Sciences
      11
      DEC 03, 2020 | 10:30 AM
      The Immunology of COVID-19: A dynamic immune signature for prognosis and spatial transcriptomics of lung tissue
      The Immunology of COVID-19: A dynamic immune signature for prognosis...
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 20...
      Speaker: Arutha Kulasinghe, PhD , Miguel Muñoz-Ruiz, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      3
      OCT 08, 2020 | 6:00 PM
      High-throughput biomarker profiling in immuno-oncology research & development
      High-throughput biomarker profiling in immuno-oncology research...
      Soluble cytokine biomarkers are the master regulators of cell-to-cell communication-- the means by which one cell tells another what to do or where to go. Determining the biomarker signature...
      Speaker: Jenny Koenitzer, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      3
      OCT 08, 2020 | 12:00 AM
      Getting Under the Hood of Racial Disparities in Prostate Cancer
      Getting Under the Hood of Racial Disparities in Prostate Cancer
      Learning Objectives: 1. Understand the evolving epidemiology of prostate cancer in the the US and globally, and the excess burden of disease borne by men of African ancestry 2. Describe the...
      Speaker: Matthew R. Cooperberg, MD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      1
    DEC 07, 2023 | 8:00 AM
    Translating COSMIC's gold standard data into actionable insights
    Translating COSMIC's gold standard data into actionable insights
    As the vast landscape of genetic oncology continues to expand, the ability to understand and utilize the full potential of this rich data becomes increasingly challenging. As a result, resea...
    Speaker: Leonie Hodges , Alex Holmes, Ph.D. , Jennifer Wilding, Ph.D.
    Sponsored By: QIAGEN
    15
    NOV 09, 2023 | 6:00 AM
    Using MERFISH to decode spatially regulated disease drivers in human heart and kidney disease
    Using MERFISH to decode spatially regulated disease drivers in...
    In this talk we will explore the application of Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology to decode spatially regulated disease drivers in human heart...
    Speaker: Christoph Kuppe, MD, MHBA
    Sponsored By: Vizgen
    8
    OCT 24, 2023 | 10:00 AM
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin profiling for scaled research & drug discovery applications
    An epic advance in epigenomics: Automated CUT&RUN enables chromatin...
    Dynamic changes in chromatin drive gene expression programs during cellular development and contribute to pathological changes underlying disease. To date, efforts to characterize chromatin...
    Speaker: Andrea Johnstone, Ph.D. , Lori Euler
    Sponsored By: Beckman Coulter Life Sciences
    30
    MAR 30, 2023 | 5:00 PM
    Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies
    Memory-rich CAR-T cell engineering by piggyBac transposon system...
    Date: March 30, 2023 Time: 5:00pm (PST), 8:00pm (EST) March 31, 2023 9:00am (JST) Chimeric antigen receptor T cell (CAR-T) therapy is still challenging in targeting solid malignancies. The q...
    Speaker: Dr. Shigeki Yagyu
    Sponsored By: MaxCyte®
    15
    MAR 01, 2023 | 8:00 AM
    Maximizing metastasis insights: Using a novel integrated workflow approach to achieve efficient CTC enrichment, enumeration and identification
    Maximizing metastasis insights: Using a novel integrated workflow...
    Date: March 01, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Characterizing metastasis remains key for understanding and eradicating cancer. The study of circulating tumor cells (CTC...
    Speaker: Adam Corner, Ph.D.
    Sponsored By: Bio-Rad Laboratories
    8
     
     
  • OCT 19, 2022 | 1:30 PM
    A Phase 1 Trial of Cyclosporine for Hospitalized Patients with COVID-19
    A Phase 1 Trial of Cyclosporine for Hospitalized Patients with...
    COVID-19 remains a global health emergency with limited treatment options, lagging vaccine rates, and inadequate healthcare resources in the face of an ongoing calamity. The disease is chara...
    Speaker: Julia Han Noll, MS
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    6
    OCT 06, 2022 | 7:30 AM
    Single-Cell Analysis of the Tumor Microenvironment in High-Grade Serous Ovarian Carcinoma (HGSOC)
    Single-Cell Analysis of the Tumor Microenvironment in High-Grade...
    Single-cell RNA sequencing (scRNA-seq) is an important technology that reveals gene expression differences between different cell types. Yet scRNA-seq data can be challenging to analyze and...
    Speaker: Jean-Noel Billaud, PhD
    Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
    Sponsored By: QIAGEN
    5
    OCT 04, 2022 | 1:30 PM
    Genomic Biomarker for Predicting Response in Early Breast Cancer Patients
    Genomic Biomarker for Predicting Response in Early Breast Cancer...
    Human solid tumors, like breast cancers, represent a heterogeneous group of diseases that is best demonstrated through many differences in clinical outcomes within homogenously treated patie...
    Speaker: Maggie Cheang, Ph.D.
    Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    5
    OCT 04, 2022 | 7:30 AM
    The Invasive Niche of Basal Cell Carcinoma as Revealed by Integrated Multi-Omics with Live Q&A
    The Invasive Niche of Basal Cell Carcinoma as Revealed by Integrated...
    Tumors invade surrounding tissue as cancer progresses, but the heterogeneity of cell types at the tumor-stroma interface and the complexity of their interactions has hampered mechanistic ins...
    Speaker: Laura Yerly
    Presented at: Cancer Research & Immuno-Oncology Week Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    3
    MAY 04, 2022 | 3:00 PM
    Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
    Deep Spatiotemporal Insights into COVID-19: a Multi-organ Study
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019...
    Speaker: Arutha Kulasinghe, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    6
     
     
  • APR 21, 2022 | 5:30 AM
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting Hypoxia
    Hypoxia Biomarkers: Personalizing Cancer Treatments by Targeting...
    A hypoxic tumour microenvironment is a feature of solid tumours. Many tumour types contain high fractions of hypoxic tissue. The relationship between high levels of tumour hypoxia and a poor...
    Speaker: Joely Irlam
    Presented at: Genetics Week Virtual Event Series 2022
    2
    MAR 10, 2022 | 7:30 AM
    Spatial Transcriptomic Profiling of Spiny Projection Neurons in the Mouse Striatum
    Spatial Transcriptomic Profiling of Spiny Projection Neurons in...
    NanoString has started an ambitious project called the "Spatial Organ Atlas." The goal of this initiative is to map the architecture of tissues with spatially resolved whole transc...
    Speaker: Alison VanSchoiack, PhD
    Presented at: Neuroscience Virtual Event Series 2022
    Sponsored By: NanoString Technologies
    3
    MAR 09, 2022 | 8:00 AM
    Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
    Biosecurity for Genome Engineering: Safety First and the SeqScreen...
    Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
    Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
    Sponsored By: Inscripta
    5
    OCT 13, 2021 | 10:30 AM
    Spatial Transcriptomic Profiling of Severe COVID-19 Patients
    Spatial Transcriptomic Profiling of Severe COVID-19 Patients
    Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. In this study, we utiliz...
    Speaker: Camilla Margaroli, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    2
    MAY 05, 2021 | 12:00 AM
    Microbiomes after Death
    Microbiomes after Death
    The postmortem microbiome is an emerging field in forensic science with broad application for death investigation (e.g., time since death). While the foundation for forensic microbiology beg...
    Speaker: Jennifer Pechal, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    1
     
     
  • APR 29, 2021 | 4:15 PM
    Comprehensive Genomic Profiling for Homologous Recombination Repair Deficiency (HRD) Assessment
    Comprehensive Genomic Profiling for Homologous Recombination Repair...
    Comprehensive genomic profiling (CGP) is advancing precision oncology research through simultaneous analysis of multiple biomarkers in a single next-generation sequencing (NGS) assay. In thi...
    Speaker: Dr. Andreas Jung
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    2
    APR 20, 2021 | 9:00 AM
    Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation and Contextualizes Alzheimer's Associated Polymorphisms
    Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation...
    Chromatin Immunoprecipitation, coupled with sequencing, has shaped our understanding of how transcriptional machinery interacts with genomes to facilitate gene regulation. These protein-DNA...
    Speaker: Cory Padilla, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: Dovetail Genomics
    1
    APR 20, 2021 | 12:00 AM
    Practical Considerations and Best Practices for Single Cell and Spatial Transcriptomics
    Practical Considerations and Best Practices for Single Cell and...
    Learning Obejctives: 1. Understand the key requirements for sample preparation in a single cell and/or spatial transcriptomics experiment 2. Learn the synergies between a combined single cel...
    Speaker: Neil Winegarden, MSc
    Presented at: Genetics Week Virtual Event Series 2021
    1
    APR 20, 2021 | 12:00 AM
    C.E. CREDITS
    Telomere-to-Telomere Chromosome Assemblies: New Insights Into Genome Biology and Structure
    Telomere-to-Telomere Chromosome Assemblies: New Insights Into...
    We are entering into an exciting era of genomics where truly complete, high-quality assemblies of human chromosomes are available end-to-end, or from ‘telomere-to-telomere’ (T2T)...
    Speaker: Karen Miga, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
    FEB 10, 2021 | 12:00 AM
    Organoids & Toxins - from snakebite to DNA-damaging bacteria
    Organoids & Toxins - from snakebite to DNA-damaging bacteria
    Organoids are emerging tools to study homeostatic function and disease of human organs. This technology has now for the first time been extended to reptiles by establishing cultures of the s...
    Speaker: Jens Puschhof
    Presented at: Laboratory Animal Sciences Virtual Event Series 2021
    2
     
     
  • JAN 27, 2021 | 9:00 AM
    Uterine B cell dynamics during pregnancy - Immune regulation of the placenta
    Uterine B cell dynamics during pregnancy - Immune regulation of...
    DATE: January 27, 2021 TIME: 9am PST Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, as the uterine immune enviro...
    Speaker: Marilen Benner
    Sponsored By: Beckman Coulter Life Sciences
    11
    DEC 03, 2020 | 10:30 AM
    The Immunology of COVID-19: A dynamic immune signature for prognosis and spatial transcriptomics of lung tissue
    The Immunology of COVID-19: A dynamic immune signature for prognosis...
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 20...
    Speaker: Arutha Kulasinghe, PhD , Miguel Muñoz-Ruiz, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    3
    OCT 08, 2020 | 6:00 PM
    High-throughput biomarker profiling in immuno-oncology research & development
    High-throughput biomarker profiling in immuno-oncology research...
    Soluble cytokine biomarkers are the master regulators of cell-to-cell communication-- the means by which one cell tells another what to do or where to go. Determining the biomarker signature...
    Speaker: Jenny Koenitzer, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    3
    OCT 08, 2020 | 12:00 AM
    Getting Under the Hood of Racial Disparities in Prostate Cancer
    Getting Under the Hood of Racial Disparities in Prostate Cancer
    Learning Objectives: 1. Understand the evolving epidemiology of prostate cancer in the the US and globally, and the excess burden of disease borne by men of African ancestry 2. Describe the...
    Speaker: Matthew R. Cooperberg, MD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    1
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