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    Gene signatures

    Gene signatures describe specific, unique characteristics of a group of genes located in a biological cell or tissue. Gene signatures can be used to diagnose diseases, including cancer. Additionally, understanding gene signatures can inform on the prognosis of disease or determine optimal treatment planning.

    Webinars

    • OCT 07, 2020 | 10:30 AM
      Immune correlates of TP53 mutational status in acute myeloid leukemia
      Immune correlates of TP53 mutational status in acute myeloid leukemia
      Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
      Speaker: Dr. Sergio Rutella
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
      Sponsored By: NanoString Technologies
      1
      SEP 23, 2020 | 10:30 AM
      New Insights Gained with Imaging Mass Cytometry
      New Insights Gained with Imaging Mass Cytometry
      Speaker TBD 10:30–10:50 am PDT Exploring the immune tumor microenvironment of hepatocellular carcinoma with Imaging Mass Cytometry™ 10:50 am–11:10 am PDT Presented By: Won...
      Speaker: Won Jin Ho, MD , Melissa B. Davis, PhD
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      1
      SEP 23, 2020 | 12:00 AM
      Transcriptomic signature : a spatially resolved analysis of the nephron structures in chronic kidney disease
      Transcriptomic signature : a spatially resolved analysis of the...
      Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
      Speaker: Paolo Cravedi, MD, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 17, 2020 | 1:30 PM
      Decoding the Variance in Intracellular Organization in Human Stem Cells
      Decoding the Variance in Intracellular Organization in Human Stem...
      The Allen Institute for Cell Science is generating a state space of stem cell signatures. The goal is to understand cell organization, identify cell states, and elucidate how cells transitio...
      Speaker: Susanne Rafelski, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      1
      SEP 16, 2020 | 12:15 PM
      High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
      High-resolution HCA-based phenotypic profiling of tumor spheroids...
      Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
      Speaker: Meritxell B. Cutrona, PhD
      Presented at: 7th Annual Conference: SBI2 High Content
      2
      SEP 09, 2020 | 12:00 AM
      Lung immune cells as drivers of influenza outcomes
      Lung immune cells as drivers of influenza outcomes
      Influenza severity is determined by the interplay between the virus and the host response. Previously, we identified a three-pronged lung gene expression signature that predicted severe infl...
      Speaker: Juliet Morrison, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      JUN 03, 2020 | 12:00 PM
      Single cell multiomic analysis of T-cell exhaustion
      Single cell multiomic analysis of T-cell exhaustion
      A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, whi...
      Speaker: Pratip K. Chattopadhyay
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: BD
      2
      JUN 03, 2020 | 6:00 AM
      Keynote Presentation: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment
      Keynote Presentation: Development of Rational Immunotherapy Combinations...
      Immune checkpoint therapies targeting the CTLA-4 and PD-(L)1 pathways have been largely clinically disappointing for patients with prostate cancer. This can be attributed to the highly immun...
      Speaker: Sumit K. Subudhi, MD, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      MAY 20, 2020 | 12:45 PM
      Molecular and Immunologic Profiling of CD8+ T Cell Responses in Patients Receiving a Multiple Antigen-Engineered Dendritic Cell Vaccine
      Molecular and Immunologic Profiling of CD8+ T Cell Responses in...
      Background: Despite the immunogenicity and safety profile of dendritic cell (DC) vaccines, the importance of vaccine-induced antigen-specific T cell responses is unclear across clinical tria...
      Speaker: Juraj Adamik, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 20, 2020 | 9:00 AM
      Keynote Presentation: Quantitative biology with droplet microfluidics
      Keynote Presentation: Quantitative biology with droplet microfluidics
      Many questions at the forefront of biology depend on the interactions of millions of single cells. My lab develops technologies for studying large numbers of single cells. In this talk, I wi...
      Speaker: Adam Abate, PhD
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1
      MAY 20, 2020 | 11:45 AM
      Immune Infiltration Correlates of TP53 Mutational Status in Acute Myeloid Leukemia
      Immune Infiltration Correlates of TP53 Mutational Status in Acute...
      Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
      Speaker: Sergio Rutella, MD, PhD, FRCPath
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 20, 2020 | 11:15 AM
      Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant Ribociclib Plus Letrozole Versus Chemotherapy in PAM50 Luminal B Early Breast Cancer
      Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant...
      Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
      Speaker: Aleix Prat, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 19, 2020 | 1:45 PM
      Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways in Cancer
      Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways...
      Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
      Speaker: Erin Piazza, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      3
      MAY 19, 2020 | 11:45 AM
      Single-nucleus and Spatial Transcriptomics of Archival Pancreatic Ductal Adenocarcinoma after Neoadjuvant Treatment
      Single-nucleus and Spatial Transcriptomics of Archival Pancreatic...
      Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory disease and existing molecular subtypes do not inform clinical decisions. Previously-identified bulk transcriptomic sub...
      Speaker: William L. Hwang, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      APR 29, 2020 | 6:00 AM
      Parsing Complex Disorders of the Gut-Immune-Brain Axis Into Clinically Meaningful Subsets: Immune Signatures as a Lens for Discovery
      Parsing Complex Disorders of the Gut-Immune-Brain Axis Into Clinically...
      ...
      Speaker: Mady Hornig, MA, MD
      Presented at: xMAP® Connect Virtual Conference (On-Demand)
      2
      APR 22, 2020 | 9:00 AM
      From Data to Biological Insight using QIAGEN OmicSoft and IPA: Single Cell Sequencing of Normal Human Liver
      From Data to Biological Insight using QIAGEN OmicSoft and IPA:...
      Single-cell RNA sequencing has emerged as an important technology that can reveal gene expression differences between different cell types. This webinar will demonstrate how bioinformatics s...
      Speaker: Jean-Noel Billaud, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      Sponsored By: QIAGEN
      1
      APR 02, 2020 | 8:00 AM
      Bionano Genome Imaging unravels complex structural rearrangements induced by replication stress in liver cancer
      Bionano Genome Imaging unravels complex structural rearrangements...
      DATE: April 2, 2020 TIME: 8:00am PT, 11:00am ET Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. We recently identified a hepatocellular carcinoma (HCC)...
      Speaker: Eric Letouzé, PhD
      Sponsored By: Bionano
      14
      OCT 30, 2019 | 7:00 AM
      A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
      A Novel Approach for Single-cell Multi-omic Analysis to Identify...
      DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
      Speaker: William J. Greenleaf, Ph.D
      Sponsored By: 10x Genomics
      18 1
      OCT 22, 2019 | 9:00 AM
      Preserving Data Integrity: 21 CFR Part 11 Compliance and Osmolality as a Process Parameter
      Preserving Data Integrity: 21 CFR Part 11 Compliance and Osmolality...
      DATE: October 22, 2019 TIME: 9:00am PDT, 12:00PM EDT...
      Speaker: Angela Bazigos , Kristeena Wright, PhD , Shweta Nair
      Sponsored By: Advanced Instruments
      10 1
      SEP 26, 2019 | 9:00 AM
      Identification of Novel Biomarker Candidates for Early Detection of Melanoma
      Identification of Novel Biomarker Candidates for Early Detection...
      Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
      Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      1
      SEP 11, 2019 | 9:00 AM
      Using metagenomics and bioinformatics to investigate bacterial-fungal interactions
      Using metagenomics and bioinformatics to investigate bacterial-fungal...
      Learning objectives:1. Metagenomic analysis is already complex, and complicated further by incomplete and non-standardized databases of known organisms2. Fungi may have their own 'mic...
      Speaker: Patrick Chain, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      Sponsored By: Illumina
      8 1
      JUN 20, 2019 | 6:00 AM
      Connecting Genetic and Transcriptional Variation in Acute Myeloid Leukemia at Single-Cell Resolution
      Connecting Genetic and Transcriptional Variation in Acute Myeloid...
      Virtually all tumors are genetically heterogeneous, containing subclonal populations of cells that are defined by distinct mutations. Subclones can have unique phenotypes that influence disea...
      Speaker: Stephen Williams, PhD
      Presented at: Precision Medicine Virtual Event Series 2019
      2
      MAY 21, 2019 | 7:00 AM
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
      DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
      Speaker: Eric Shifrut, PhD
      Sponsored By: Thermo Fisher Scientific
      10 1
      MAY 09, 2019 | 12:00 PM
      A Metagenomic Assay to Interrogate the Role of Virome and Microbiome in Cancer
      A Metagenomic Assay to Interrogate the Role of Virome and Microbiome...
      Screening to identify all known viruses and other pathogenic microorganisms including bacteria, fungus and parasites in human tumor tissues will provide a more comprehensive understanding of...
      Speaker: Erle Robertson, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      Sponsored By: Agilent
      3
    OCT 07, 2020 | 10:30 AM
    Immune correlates of TP53 mutational status in acute myeloid leukemia
    Immune correlates of TP53 mutational status in acute myeloid leukemia
    Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
    Speaker: Dr. Sergio Rutella
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2020
    Sponsored By: NanoString Technologies
    1
    SEP 23, 2020 | 10:30 AM
    New Insights Gained with Imaging Mass Cytometry
    New Insights Gained with Imaging Mass Cytometry
    Speaker TBD 10:30–10:50 am PDT Exploring the immune tumor microenvironment of hepatocellular carcinoma with Imaging Mass Cytometry™ 10:50 am–11:10 am PDT Presented By: Won...
    Speaker: Won Jin Ho, MD , Melissa B. Davis, PhD
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    1
    SEP 23, 2020 | 12:00 AM
    Transcriptomic signature : a spatially resolved analysis of the nephron structures in chronic kidney disease
    Transcriptomic signature : a spatially resolved analysis of the...
    Chronic kidney disease (CKD) is a global health threat, affecting over 10% of the world population, including an estimated 37 million Americans. Importantly, glomerular diseases account for...
    Speaker: Paolo Cravedi, MD, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 17, 2020 | 1:30 PM
    Decoding the Variance in Intracellular Organization in Human Stem Cells
    Decoding the Variance in Intracellular Organization in Human Stem...
    The Allen Institute for Cell Science is generating a state space of stem cell signatures. The goal is to understand cell organization, identify cell states, and elucidate how cells transitio...
    Speaker: Susanne Rafelski, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    1
    SEP 16, 2020 | 12:15 PM
    High-resolution HCA-based phenotypic profiling of tumor spheroids and organoids
    High-resolution HCA-based phenotypic profiling of tumor spheroids...
    Image-based high-content screening (HCS) involving cancer cell lines grown in conventional two-dimensional (2D) cell culture, has provided a cornerstone assay for searching new agents to tre...
    Speaker: Meritxell B. Cutrona, PhD
    Presented at: 7th Annual Conference: SBI2 High Content
    2
     
     
  • SEP 09, 2020 | 12:00 AM
    Lung immune cells as drivers of influenza outcomes
    Lung immune cells as drivers of influenza outcomes
    Influenza severity is determined by the interplay between the virus and the host response. Previously, we identified a three-pronged lung gene expression signature that predicted severe infl...
    Speaker: Juliet Morrison, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    JUN 03, 2020 | 12:00 PM
    Single cell multiomic analysis of T-cell exhaustion
    Single cell multiomic analysis of T-cell exhaustion
    A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, whi...
    Speaker: Pratip K. Chattopadhyay
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: BD
    2
    JUN 03, 2020 | 6:00 AM
    Keynote Presentation: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment
    Keynote Presentation: Development of Rational Immunotherapy Combinations...
    Immune checkpoint therapies targeting the CTLA-4 and PD-(L)1 pathways have been largely clinically disappointing for patients with prostate cancer. This can be attributed to the highly immun...
    Speaker: Sumit K. Subudhi, MD, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    MAY 20, 2020 | 12:45 PM
    Molecular and Immunologic Profiling of CD8+ T Cell Responses in Patients Receiving a Multiple Antigen-Engineered Dendritic Cell Vaccine
    Molecular and Immunologic Profiling of CD8+ T Cell Responses in...
    Background: Despite the immunogenicity and safety profile of dendritic cell (DC) vaccines, the importance of vaccine-induced antigen-specific T cell responses is unclear across clinical tria...
    Speaker: Juraj Adamik, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 20, 2020 | 9:00 AM
    Keynote Presentation: Quantitative biology with droplet microfluidics
    Keynote Presentation: Quantitative biology with droplet microfluidics
    Many questions at the forefront of biology depend on the interactions of millions of single cells. My lab develops technologies for studying large numbers of single cells. In this talk, I wi...
    Speaker: Adam Abate, PhD
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1
     
     
  • MAY 20, 2020 | 11:45 AM
    Immune Infiltration Correlates of TP53 Mutational Status in Acute Myeloid Leukemia
    Immune Infiltration Correlates of TP53 Mutational Status in Acute...
    Tumor phenotypes are dictated not only by the neoplastic cell component, but also by the tumor microenvironment (TME), which is inherently immuno-suppressive, is equipped to hamper effector...
    Speaker: Sergio Rutella, MD, PhD, FRCPath
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 20, 2020 | 11:15 AM
    Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant Ribociclib Plus Letrozole Versus Chemotherapy in PAM50 Luminal B Early Breast Cancer
    Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant...
    Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
    Speaker: Aleix Prat, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 19, 2020 | 1:45 PM
    Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways in Cancer
    Tumor Signaling 360 Panel: A 360° View of Altered Signaling Pathways...
    Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
    Speaker: Erin Piazza, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    3
    MAY 19, 2020 | 11:45 AM
    Single-nucleus and Spatial Transcriptomics of Archival Pancreatic Ductal Adenocarcinoma after Neoadjuvant Treatment
    Single-nucleus and Spatial Transcriptomics of Archival Pancreatic...
    Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory disease and existing molecular subtypes do not inform clinical decisions. Previously-identified bulk transcriptomic sub...
    Speaker: William L. Hwang, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    APR 29, 2020 | 6:00 AM
    Parsing Complex Disorders of the Gut-Immune-Brain Axis Into Clinically Meaningful Subsets: Immune Signatures as a Lens for Discovery
    Parsing Complex Disorders of the Gut-Immune-Brain Axis Into Clinically...
    ...
    Speaker: Mady Hornig, MA, MD
    Presented at: xMAP® Connect Virtual Conference (On-Demand)
    2
     
     
  • APR 22, 2020 | 9:00 AM
    From Data to Biological Insight using QIAGEN OmicSoft and IPA: Single Cell Sequencing of Normal Human Liver
    From Data to Biological Insight using QIAGEN OmicSoft and IPA:...
    Single-cell RNA sequencing has emerged as an important technology that can reveal gene expression differences between different cell types. This webinar will demonstrate how bioinformatics s...
    Speaker: Jean-Noel Billaud, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    Sponsored By: QIAGEN
    1
    APR 02, 2020 | 8:00 AM
    Bionano Genome Imaging unravels complex structural rearrangements induced by replication stress in liver cancer
    Bionano Genome Imaging unravels complex structural rearrangements...
    DATE: April 2, 2020 TIME: 8:00am PT, 11:00am ET Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. We recently identified a hepatocellular carcinoma (HCC)...
    Speaker: Eric Letouzé, PhD
    Sponsored By: Bionano
    14
    OCT 30, 2019 | 7:00 AM
    A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
    A Novel Approach for Single-cell Multi-omic Analysis to Identify...
    DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
    Speaker: William J. Greenleaf, Ph.D
    Sponsored By: 10x Genomics
    18 1
    OCT 22, 2019 | 9:00 AM
    Preserving Data Integrity: 21 CFR Part 11 Compliance and Osmolality as a Process Parameter
    Preserving Data Integrity: 21 CFR Part 11 Compliance and Osmolality...
    DATE: October 22, 2019 TIME: 9:00am PDT, 12:00PM EDT...
    Speaker: Angela Bazigos , Kristeena Wright, PhD , Shweta Nair
    Sponsored By: Advanced Instruments
    10 1
    SEP 26, 2019 | 9:00 AM
    Identification of Novel Biomarker Candidates for Early Detection of Melanoma
    Identification of Novel Biomarker Candidates for Early Detection...
    Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
    Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    1
     
     
  • SEP 11, 2019 | 9:00 AM
    Using metagenomics and bioinformatics to investigate bacterial-fungal interactions
    Using metagenomics and bioinformatics to investigate bacterial-fungal...
    Learning objectives:1. Metagenomic analysis is already complex, and complicated further by incomplete and non-standardized databases of known organisms2. Fungi may have their own 'mic...
    Speaker: Patrick Chain, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    Sponsored By: Illumina
    8 1
    JUN 20, 2019 | 6:00 AM
    Connecting Genetic and Transcriptional Variation in Acute Myeloid Leukemia at Single-Cell Resolution
    Connecting Genetic and Transcriptional Variation in Acute Myeloid...
    Virtually all tumors are genetically heterogeneous, containing subclonal populations of cells that are defined by distinct mutations. Subclones can have unique phenotypes that influence disea...
    Speaker: Stephen Williams, PhD
    Presented at: Precision Medicine Virtual Event Series 2019
    2
    MAY 21, 2019 | 7:00 AM
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
    DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
    Speaker: Eric Shifrut, PhD
    Sponsored By: Thermo Fisher Scientific
    10 1
    MAY 09, 2019 | 12:00 PM
    A Metagenomic Assay to Interrogate the Role of Virome and Microbiome in Cancer
    A Metagenomic Assay to Interrogate the Role of Virome and Microbiome...
    Screening to identify all known viruses and other pathogenic microorganisms including bacteria, fungus and parasites in human tumor tissues will provide a more comprehensive understanding of...
    Speaker: Erle Robertson, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    Sponsored By: Agilent
    3
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