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    In-situ Hybridization

    In-Situ hybridization is a laboratory technique that detects genetic expression within a cell. A known RNA or DNA sequence, called a probe, is generated, and allowed to bind to the DNA or RNA present in a test sample. The probe is able to be visualized to identify the genetic sequence in the sample.

    Webinars

    • NOV 09, 2023 | 6:00 AM
      Using MERFISH to decode spatially regulated disease drivers in human heart and kidney disease
      Using MERFISH to decode spatially regulated disease drivers in...
      In this talk we will explore the application of Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology to decode spatially regulated disease drivers in human heart...
      Speaker: Christoph Kuppe, MD, MHBA
      Sponsored By: Vizgen
      8
      JUL 18, 2023 2:00 PM EDT
      Biomarkers in Gastric Cancer: An Overview
      Biomarkers in Gastric Cancer: An Overview
      Worldwide gastric cancer is the 5th most common cancer and the 4th leading cause of cancer deaths. Its highest incidence rates are in east Asia and eastern Europe with low incidence rates in...
      Speaker: Stuti Shroff, MD, MBBS, PhD
      Presented at: Precision Medicine in Solid Tumors
      11
      MAR 08, 2023 | 1:30 PM
      Spatial Mapping of Pain-Associated G-Protein Coupled Receptors and Biomarker Localization in Mouse Brain Using RNAscope HiPlex v2 and RNA-Protein Co-Detection Assay with Live Q&A
      Spatial Mapping of Pain-Associated G-Protein Coupled Receptors...
      Spatial mapping of pain-associated G-Protein coupled receptors and bio-marker localization in mouse brain using RNAscope HiPlex v2 and RNA-Protein Co-Detection Assays....
      Speaker: Sayantani Basak, PhD
      Presented at: Neuroscience Virtual Event Series 2023
      Sponsored By: ACD, a Bio-Techne brand
      2
      FEB 23, 2023 | 8:00 AM
      Combining RNAscope™ Technology with Protein Detection: A Multi Omics approach using RNA-Protein Integrated Co-Detection Workflow (ICW)
      Combining RNAscope™ Technology with Protein Detection: A Multi...
      Date: February 23, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The RNAscope in situ hybridization (ISH) technology is a powerful method for detecting gene expression with spatial an...
      Speaker: Blake McAlpin, PhD
      Sponsored By: Leica Biosystems
      16
      FEB 14, 2023 | 10:00 AM
      A spatially-resolved transcriptional atlas of the murine dorsal pontine tegmentum
      A spatially-resolved transcriptional atlas of the murine dorsal...
      Date: February 14, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The dorsal pontine tegmentum (PnTg) is part of the Pons, the largest section of the brainstem. It is a complex region...
      Speaker: Stefano Nardone, PhD , Cory Brannigan
      Sponsored By: Vizgen
      6
      NOV 17, 2022 | 8:00 AM
      Tips, Tricks, and Optimization: A User's Guide to BOND RX and Chromogenic Multiplexing in Research Applications
      Tips, Tricks, and Optimization: A User's Guide to BOND RX and...
      Date: November 17, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Have you ever wished you had access to the technical specialist who wrote the book ......
      Speaker: Mark Lawson
      Sponsored By: Leica Biosystems
      10
      NOV 17, 2022 | 7:00 AM
      Visualizing in situ single-cell multi-omic gene expression from FFPE Tissue with MERSCOPE
      Visualizing in situ single-cell multi-omic gene expression from...
      Date: November 17, 2022 Time: 7:00am (PST), 10:00am (EST), 4:00pm (CET) In order to truly understand cell biology, researchers need easy-to-use tools that preserve the natural complexity of...
      Speaker: Peter Reinhold
      Sponsored By: Vizgen
      13
      OCT 26, 2022 | 8:00 AM
      Spatially defining the future of cancer biology with advanced multiplexed immunofluorescence
      Spatially defining the future of cancer biology with advanced...
      Date: October 26, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors. Advances in technology in the pa...
      Speaker: Troy Bloom
      Sponsored By: Ultivue
      7
      MAY 31, 2022 | 9:00 AM
      Interrogate tumor-immune interactions in AML patients receiving immune checkpoint inhibitor
      Interrogate tumor-immune interactions in AML patients receiving...
      Date: May 31, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Introducing Nanostring’s latest spatial platform, CosMx Spatial Molecular Imager (SMI). Offering high-plex, multiomi...
      Speaker: Vikram Devgan, PhD, MBA , Dr. Chen Zhao
      Sponsored By: NanoString Technologies
      14
      MAY 24, 2022 | 11:00 AM
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
      Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
      Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
      Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
      Sponsored By: BioDiscovery, A Bionano Genomics Company
      18
      MAR 31, 2022 | 11:00 AM
      In situ single-cell transcriptomic imaging in formalin-fixed paraffin-embedded (FFPE) tissues with MERSCOPE
      In situ single-cell transcriptomic imaging in formalin-fixed paraffin-embedded...
      Date: March 31, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular...
      Speaker: Jiang He
      Sponsored By: Vizgen
      8 1
      JAN 20, 2022 | 8:00 AM
      Modernization of tissue-based, biomarker-led clinical research
      Modernization of tissue-based, biomarker-led clinical research
      Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
      Speaker: Dr Stephanie Craig
      Sponsored By: Leica Biosystems
      15 1
      DEC 07, 2021 | 10:00 AM
      An overview of a novel RNAscope™ in situ hybridization technology, and applications in pathology of animal models
      An overview of a novel RNAscope™ in situ hybridization technology,...
      Date: December 07, 2021 Time: 10:00am (PST) The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights in...
      Speaker: Anushka Dikshit, PhD , Sebastien Monette
      Sponsored By: ACD, a Bio-Techne brand
      1
      OCT 26, 2021 | 11:00 AM
      Constructing a Spatially Resolved Single-cell Atlas of the Mouse Retina with the MERSCOPE Platform
      Constructing a Spatially Resolved Single-cell Atlas of the Mouse...
      Date: October 26, 2021 Time: 11:00am (PDT), 1:00pm (EDT) The retina is the light-sensing part of the visual system and is composed of six neuron types and several non-neuronal cell types, wi...
      Speaker: Rui Chen, B.S., Ph.D.
      Sponsored By: Vizgen
      5
      AUG 25, 2021 | 1:30 PM
      Spatial Context Matters: Molecular Cartography™ to Study Gene Expression Changes in the Brain
      Spatial Context Matters: Molecular Cartography™ to Study Gene...
      Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
      Speaker: Jeroen Aerts, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      Sponsored By: Resolve Biosciences
      1
      NOV 19, 2020 | 9:00 AM
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
      Speaker: Kok Hao Chen , Alan Mullan, PhD
      Sponsored By: Andor
      6 2
      JUL 02, 2020 | 2:00 PM
      Applications of CytoMicroarrays
      Applications of CytoMicroarrays
      Genomic imbalances or copy number variations (CNVs) are a major cause of pregnancy losses, fetal anomalies identified during prenatal period, congenital defects in newborn, dysmorphology and...
      Speaker: Anuradha Udumudi, PhD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      2
      JUN 30, 2020 | 8:00 AM
      Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex Technology
      Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex...
      DATE: June 30, 2020 TIME: 8:00am PT, 11:00am Understanding the tumor microenvironment (TME) is essential for the development of effective treatments for cancer patients. Traditional multi...
      Speaker: Chifei Sun
      Sponsored By: Leica Biosystems
      19
      MAY 19, 2020 | 1:15 PM
      Spatial Mapping of Gene Expression in Tumors using the RNAscope™ Technology
      Spatial Mapping of Gene Expression in Tumors using the RNAscope™...
      The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
      Speaker: Anushka Dikshit, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      3
      APR 16, 2020 | 9:00 AM
      Visualize more biomarkers and extract more insights: Moving from single marker IHC to multiplex IF
      Visualize more biomarkers and extract more insights: Moving from...
      DATE: April 16, 2020 TIME: 9:00am PT, 12:00pm ET There is an increasing need to evaluate and understand unique phenotypes and mechanisms of action within the tumor microenvironment. Existing...
      Speaker: Scott Lawrence (M.S., HT(ASCP)) [C] , Katir Patel, PhD
      Sponsored By: Ultivue
      5
      DEC 05, 2019 | 9:00 AM
      Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
      Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
      DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
      Speaker: Mathias Holpert, PhD , Traci DeGeer, BS, HT (ASCP) HTL, QIHC
      Sponsored By: Leica Biosystems, NanoString Technologies
      8
      SEP 05, 2019 | 7:00 AM
      The bread and butter method of genomics: How to improve your (q)PCR
      The bread and butter method of genomics: How to improve your (q)PCR
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      Speaker: Tim Schommartz, PhD
      Sponsored By: Eppendorf
      17 1
    NOV 09, 2023 | 6:00 AM
    Using MERFISH to decode spatially regulated disease drivers in human heart and kidney disease
    Using MERFISH to decode spatially regulated disease drivers in...
    In this talk we will explore the application of Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH) technology to decode spatially regulated disease drivers in human heart...
    Speaker: Christoph Kuppe, MD, MHBA
    Sponsored By: Vizgen
    8
    JUL 18, 2023 2:00 PM EDT
    Biomarkers in Gastric Cancer: An Overview
    Biomarkers in Gastric Cancer: An Overview
    Worldwide gastric cancer is the 5th most common cancer and the 4th leading cause of cancer deaths. Its highest incidence rates are in east Asia and eastern Europe with low incidence rates in...
    Speaker: Stuti Shroff, MD, MBBS, PhD
    Presented at: Precision Medicine in Solid Tumors
    11
    MAR 08, 2023 | 1:30 PM
    Spatial Mapping of Pain-Associated G-Protein Coupled Receptors and Biomarker Localization in Mouse Brain Using RNAscope HiPlex v2 and RNA-Protein Co-Detection Assay with Live Q&A
    Spatial Mapping of Pain-Associated G-Protein Coupled Receptors...
    Spatial mapping of pain-associated G-Protein coupled receptors and bio-marker localization in mouse brain using RNAscope HiPlex v2 and RNA-Protein Co-Detection Assays....
    Speaker: Sayantani Basak, PhD
    Presented at: Neuroscience Virtual Event Series 2023
    Sponsored By: ACD, a Bio-Techne brand
    2
    FEB 23, 2023 | 8:00 AM
    Combining RNAscope™ Technology with Protein Detection: A Multi Omics approach using RNA-Protein Integrated Co-Detection Workflow (ICW)
    Combining RNAscope™ Technology with Protein Detection: A Multi...
    Date: February 23, 2023 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The RNAscope in situ hybridization (ISH) technology is a powerful method for detecting gene expression with spatial an...
    Speaker: Blake McAlpin, PhD
    Sponsored By: Leica Biosystems
    16
    FEB 14, 2023 | 10:00 AM
    A spatially-resolved transcriptional atlas of the murine dorsal pontine tegmentum
    A spatially-resolved transcriptional atlas of the murine dorsal...
    Date: February 14, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The dorsal pontine tegmentum (PnTg) is part of the Pons, the largest section of the brainstem. It is a complex region...
    Speaker: Stefano Nardone, PhD , Cory Brannigan
    Sponsored By: Vizgen
    6
     
     
  • NOV 17, 2022 | 8:00 AM
    Tips, Tricks, and Optimization: A User's Guide to BOND RX and Chromogenic Multiplexing in Research Applications
    Tips, Tricks, and Optimization: A User's Guide to BOND RX and...
    Date: November 17, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) Have you ever wished you had access to the technical specialist who wrote the book ......
    Speaker: Mark Lawson
    Sponsored By: Leica Biosystems
    10
    NOV 17, 2022 | 7:00 AM
    Visualizing in situ single-cell multi-omic gene expression from FFPE Tissue with MERSCOPE
    Visualizing in situ single-cell multi-omic gene expression from...
    Date: November 17, 2022 Time: 7:00am (PST), 10:00am (EST), 4:00pm (CET) In order to truly understand cell biology, researchers need easy-to-use tools that preserve the natural complexity of...
    Speaker: Peter Reinhold
    Sponsored By: Vizgen
    13
    OCT 26, 2022 | 8:00 AM
    Spatially defining the future of cancer biology with advanced multiplexed immunofluorescence
    Spatially defining the future of cancer biology with advanced...
    Date: October 26, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors. Advances in technology in the pa...
    Speaker: Troy Bloom
    Sponsored By: Ultivue
    7
    MAY 31, 2022 | 9:00 AM
    Interrogate tumor-immune interactions in AML patients receiving immune checkpoint inhibitor
    Interrogate tumor-immune interactions in AML patients receiving...
    Date: May 31, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Introducing Nanostring’s latest spatial platform, CosMx Spatial Molecular Imager (SMI). Offering high-plex, multiomi...
    Speaker: Vikram Devgan, PhD, MBA , Dr. Chen Zhao
    Sponsored By: NanoString Technologies
    14
    MAY 24, 2022 | 11:00 AM
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination Deficiency (HRD): Expanding NGS Data to View Events Associated with Genomic Instability
    Next-Generation Sequencing (NGS) Assessment of Homologous Recombination...
    Date: May 24, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 7:00pm (CEST) NGS tumor profiling has become the mainstay of modern cancer therapy. Several NCCN-guided and FDA-approved therapies are c...
    Speaker: Dr. Christopher Lum, M.D. , Zan Halford, M.S. SMB(ASCP)CM,
    Sponsored By: BioDiscovery, A Bionano Genomics Company
    18
     
     
  • MAR 31, 2022 | 11:00 AM
    In situ single-cell transcriptomic imaging in formalin-fixed paraffin-embedded (FFPE) tissues with MERSCOPE
    In situ single-cell transcriptomic imaging in formalin-fixed paraffin-embedded...
    Date: March 31, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CET) Formalin-fixed paraffin-embedded (FFPE) tissues are the most widely used clinical sample types in histology and molecular...
    Speaker: Jiang He
    Sponsored By: Vizgen
    8 1
    JAN 20, 2022 | 8:00 AM
    Modernization of tissue-based, biomarker-led clinical research
    Modernization of tissue-based, biomarker-led clinical research
    Date: January 20, 2021 Time: 08:00am (PST), 11:00am (EST) Automated staining platforms and digital slide scanners have revolutionized tissue-based biomarker research by providing a powerful...
    Speaker: Dr Stephanie Craig
    Sponsored By: Leica Biosystems
    15 1
    DEC 07, 2021 | 10:00 AM
    An overview of a novel RNAscope™ in situ hybridization technology, and applications in pathology of animal models
    An overview of a novel RNAscope™ in situ hybridization technology,...
    Date: December 07, 2021 Time: 10:00am (PST) The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights in...
    Speaker: Anushka Dikshit, PhD , Sebastien Monette
    Sponsored By: ACD, a Bio-Techne brand
    1
    OCT 26, 2021 | 11:00 AM
    Constructing a Spatially Resolved Single-cell Atlas of the Mouse Retina with the MERSCOPE Platform
    Constructing a Spatially Resolved Single-cell Atlas of the Mouse...
    Date: October 26, 2021 Time: 11:00am (PDT), 1:00pm (EDT) The retina is the light-sensing part of the visual system and is composed of six neuron types and several non-neuronal cell types, wi...
    Speaker: Rui Chen, B.S., Ph.D.
    Sponsored By: Vizgen
    5
    AUG 25, 2021 | 1:30 PM
    Spatial Context Matters: Molecular Cartography™ to Study Gene Expression Changes in the Brain
    Spatial Context Matters: Molecular Cartography™ to Study Gene...
    Technological advances such as single-cell RNA sequencing accelerated our understanding of cellular diversity in tissues. However, the ability to elucidate this cellular heterogeneity while...
    Speaker: Jeroen Aerts, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    Sponsored By: Resolve Biosciences
    1
     
     
  • NOV 19, 2020 | 9:00 AM
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
    Speaker: Kok Hao Chen , Alan Mullan, PhD
    Sponsored By: Andor
    6 2
    JUL 02, 2020 | 2:00 PM
    Applications of CytoMicroarrays
    Applications of CytoMicroarrays
    Genomic imbalances or copy number variations (CNVs) are a major cause of pregnancy losses, fetal anomalies identified during prenatal period, congenital defects in newborn, dysmorphology and...
    Speaker: Anuradha Udumudi, PhD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    2
    JUN 30, 2020 | 8:00 AM
    Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex Technology
    Phenotyping the Tumor Microenvironment Using DNA Barcoded Multiplex...
    DATE: June 30, 2020 TIME: 8:00am PT, 11:00am Understanding the tumor microenvironment (TME) is essential for the development of effective treatments for cancer patients. Traditional multi...
    Speaker: Chifei Sun
    Sponsored By: Leica Biosystems
    19
    MAY 19, 2020 | 1:15 PM
    Spatial Mapping of Gene Expression in Tumors using the RNAscope™ Technology
    Spatial Mapping of Gene Expression in Tumors using the RNAscope™...
    The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
    Speaker: Anushka Dikshit, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    3
    APR 16, 2020 | 9:00 AM
    Visualize more biomarkers and extract more insights: Moving from single marker IHC to multiplex IF
    Visualize more biomarkers and extract more insights: Moving from...
    DATE: April 16, 2020 TIME: 9:00am PT, 12:00pm ET There is an increasing need to evaluate and understand unique phenotypes and mechanisms of action within the tumor microenvironment. Existing...
    Speaker: Scott Lawrence (M.S., HT(ASCP)) [C] , Katir Patel, PhD
    Sponsored By: Ultivue
    5
     
     
  • DEC 05, 2019 | 9:00 AM
    Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
    Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
    DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
    Speaker: Mathias Holpert, PhD , Traci DeGeer, BS, HT (ASCP) HTL, QIHC
    Sponsored By: Leica Biosystems, NanoString Technologies
    8
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    The bread and butter method of genomics: How to improve your (q)PCR
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