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    Natural variation

    Natural, or genetic, variation is the occurrence of naturally occurring differences in DNA sequence between individuals of the same species. Natural variation arises as a result of random mutations which are passed from parent to offspring. Examples of natural variation among the human population include hair color, freckles, and blood type.

    Webinars

    • FEB 22, 2023 | 5:30 AM
      Current Use of GPCR Pharmacogenomics in Clinical Practice
      Current Use of GPCR Pharmacogenomics in Clinical Practice
      G Protein Coupled Receptors (GPCRs) are therapeutic targets for many medications used to treat a variety of disease states. A large number of genetic variants have been identified in the gen...
      Speaker: Helen E. Smith, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2023
      1
      JUN 01, 2022 | 9:00 AM
      The Art and Science of Hematology Morphology: Platelet Morphology
      The Art and Science of Hematology Morphology: Platelet Morphology
      Date: June 01, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) The enumeration and analysis of blood cells with automated haematology analysers have significantly improved in recent ye...
      Speaker: Daniel Pelling, CSci, FIBMS, DFM
      Sponsored By: Abbott
      56
      MAY 11, 2022 | 12:00 PM
      Conserving California: Applying Whole Genome Sequencing in the California Conservation Genomics Project (CCGP)
      Conserving California: Applying Whole Genome Sequencing in the...
      Date: May 11, 2022 Time: 12:00pm (PDT), 3:00pm (EDT), 9:00pm (CEST) In this presentation, Dr. Courtney Miller and Daniel Rodrigues Oliveira, M.S. will describe the efforts of the California...
      Speaker: Daniel Rodrigues Oliveira, M.S. , Courtney Miller, Ph.D. , Ariele Hanek, Ph.D.
      Sponsored By: seqWell
      15
      DEC 01, 2021 | 9:00 AM
      The Art and Science of Haematology Morphology: RBC Morphology
      The Art and Science of Haematology Morphology: RBC Morphology
      Date: December 1, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The enumeration and analysis of blood cells with automated haematology analysers have significantly improved in recent years due to a...
      Speaker: Daniel Pelling, CSci, FIBMS, DFM
      Sponsored By: Abbott
      32
      SEP 28, 2021 | 9:00 AM
      New method for standardized, high-throughput PBMC isolation from blood samples for observational and clinical studies
      New method for standardized, high-throughput PBMC isolation from...
      Date: September 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Standardization and reproducibility are prerequisites for peripheral blood mononuclear cell (PBMC) generation from donor or patient...
      Speaker: Lotta Raty , Dr. Steffen Rapp , PhD
      Sponsored By: Miltenyi Biotec
      10 1
      JUN 02, 2021 | 10:00 AM
      Recent advances for simultaneous analysis to determine embryo PGT-A and PGT-M status with NGS
      Recent advances for simultaneous analysis to determine embryo...
      Date: June 2, 2021 Time: 10:00am PDT Preimplantation genetic testing (PGT) is typically performed on a limited number of cells from an embryo biopsy and is used to prioritize embryos for tra...
      Speaker: Cengiz Cinnioglu, PhD
      Sponsored By: Thermo Fisher Scientific
      13
      MAY 05, 2021 | 12:00 AM
      Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
      Leveraging Bioinformatic Resources to Better Tackle Challenging...
      Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
      Speaker: Frank Wendt, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      1
      APR 20, 2021 | 7:30 AM
      C.E. CREDITS
      Keynote Presentation: A structural variation map of 499 Han Chinese individuals using long-read sequencing data
      Keynote Presentation: A structural variation map of 499 Han Chinese...
      Structural variants (SVs) are essential in human evolution and genetic disease but remain understudied. This is especially the case for non-Caucasian ethnicities. We report, for the first ti...
      Speaker: Fritz Sedlazeck, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      1
      FEB 24, 2021 | 12:00 PM
      Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
      Deep Mechanistic profiling of immune oncology drug combinations...
      With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
      Speaker: Jason Frazier , Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: NanoString Technologies
      2
      FEB 24, 2021 | 12:00 AM
      Preclinical evaluation of novel OT-analogs for the potential treatment of social behavioral deficits
      Preclinical evaluation of novel OT-analogs for the potential treatment...
      As pharmaceutical companies have reduced or eliminated neuroscience drug development due to high costs and low approval rates, the economic and healthcare burden of CNS disorders in the Unit...
      Speaker: Marsha Pierce, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      2
      DEC 03, 2020 | 12:00 AM
      Recent insights into SARS-CoV-2 intra-host population dynamics
      Recent insights into SARS-CoV-2 intra-host population dynamics
      The fast spread and deadliness of SARS-CoV-2 has sparked much interest in understanding the underlying genomics and evolutionary patterns of this 30,000bp Coronavirus. Since the first report...
      Speaker: Todd Treangen, PhD
      Presented at: Coronavirus Series
      3 1
      NOV 16, 2020 | 5:00 AM
      Diabetes and the Clinical Laboratory
      Diabetes and the Clinical Laboratory
      DATE: November 16, 2020 TIME: 05:00am PST, 2:00pm CET It may be impossible to stop the inexorable move towards pandemic levels of diabetes, but we can improve the glycaemic control in our pa...
      Speaker: Professor Garry John, PhD, FRCPath
      Sponsored By: Abbott Diagnostics
      11 1
      OCT 22, 2020 | 6:05 AM
      NGS for precision oncology in solid tumors: from research to clinical practice
      NGS for precision oncology in solid tumors: from research to clinical...
      Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
      Speaker: Nicola Normanno, MD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 22, 2020 | 6:05 AM
      NGS for precision oncology in solid tumors: from research to clinical practice
      NGS for precision oncology in solid tumors: from research to clinical...
      Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
      Speaker: Nicola Normanno, MD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      0
      SEP 23, 2020 | 12:00 AM
      Deep learning to integrate histology with spatial transcriptomics
      Deep learning to integrate histology with spatial transcriptomics
      I will present our new computer vision algorithm, ST-Net, which can computationally synthesize spatially resolved transcriptomics directly from H&E histology images (He et al. Nature Bio...
      Speaker: James Zou
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 09, 2020 | 6:00 AM
      Keynote Presentation: Causes and consequences of immune gene diversity in plants
      Keynote Presentation: Causes and consequences of immune gene diversity...
      My group is addressing fundamental questions in evolutionary biology, using both genome- and phenotype-first approaches. A few years ago, we discovered that Arabidopsis thaliana is a great m...
      Speaker: Detlef Weigel, Executive Director
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 08, 2020 | 11:00 PM
      Deep Learning by Analogy: Applying Text and Image Processing Techniques to Sequence Analysis
      Deep Learning by Analogy: Applying Text and Image Processing Techniques...
      Over the past five years there has been an explosion of research the deep learning field. Companies like Google, Facebook, and OpenAI have created neural networks that are significantly more...
      Speaker: Will Dampier, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      JUN 26, 2020 | 8:00 AM
      Next-Generation Cytogenetics: international, multi-center study of chromosomal aberrations in constitutional diseases and leukemia with Bionano genome imaging
      Next-Generation Cytogenetics: international, multi-center study...
      DATE: June 26, 2020 TIME: 8:00am PT Structural variants (SVs) are an important source of genetic variation in the human genome and they are involved in a multitude of human diseases as well...
      Speaker: Alexander Hoischen , Laila El Khattabi
      Sponsored By: Bionano
      16
      JUN 17, 2020 | 4:30 PM
      Patterns of Intrahost and Interhost variation in SARS-CoV-2
      Patterns of Intrahost and Interhost variation in SARS-CoV-2
      The fast spread of SARS-Cov-2 sparked much interest in understanding the underlying genomics of this 30,000bp Coronavirus. Thus far, thousands of genome assemblies are available, yet they fe...
      Speaker: Todd Treangen, PhD
      Presented at: Coronavirus Series
      1
      MAY 14, 2020 | 2:40 PM
      Oncomine Precision Assay on Ion Torrent Genexus System for liquid biopsy sample
      Oncomine Precision Assay on Ion Torrent Genexus System for liquid...
      Molecular profiling is key in precision oncology research and whilst the tissue testing has become a routine, liquid biopsy might provide a non-invasive alternative when tissue biopsy is ina...
      Speaker: Siew-Kee (Amanda) Low, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      8
      MAY 14, 2020 | 2:40 PM
      Oncomine Precision Assay on Ion Torrent Genexus System for liquid biopsy sample
      Oncomine Precision Assay on Ion Torrent Genexus System for liquid...
      The development of molecular targeted therapy is one of the breakthroughs in oncology field. Molecular profiling of the tumor becomes mandatory in the routine clinical practice to select the...
      Speaker: Siew-Kee (Amanda) Low, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      OCT 24, 2019 | 1:30 PM
      Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
      Characterization of Biotherapeutics by Chemometric and Machine...
      With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
      Speaker: Frank Delaglio, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2019
      4 1
      MAY 08, 2019 | 1:30 PM
      Highly Accurate Long Sequence Reads for Comprehensive Genomic Analysis
      Highly Accurate Long Sequence Reads for Comprehensive Genomic...
      Recent improvements in sequencing chemistry and instrument performance combine to create a new PacBio data type of highly accurate (HiFi), long insert reads. Increased read length and improve...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      Sponsored By: PacBio
      2
      NOV 08, 2018 | 5:00 PM
      NMR in standardizing biomarkers for personalized medicine: Where do biobanks come in?  (For research use only)
      NMR in standardizing biomarkers for personalized medicine: Where...
      DATE:  November 9, 2018 TIME:   09:00am CST, 10:00am JST, 12:00pm AEDT Perso and precision medicine are rapidly growing areas that require good data to categoriz...
      Speaker: Matthias Nauck, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      3
    FEB 22, 2023 | 5:30 AM
    Current Use of GPCR Pharmacogenomics in Clinical Practice
    Current Use of GPCR Pharmacogenomics in Clinical Practice
    G Protein Coupled Receptors (GPCRs) are therapeutic targets for many medications used to treat a variety of disease states. A large number of genetic variants have been identified in the gen...
    Speaker: Helen E. Smith, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2023
    1
    JUN 01, 2022 | 9:00 AM
    The Art and Science of Hematology Morphology: Platelet Morphology
    The Art and Science of Hematology Morphology: Platelet Morphology
    Date: June 01, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) The enumeration and analysis of blood cells with automated haematology analysers have significantly improved in recent ye...
    Speaker: Daniel Pelling, CSci, FIBMS, DFM
    Sponsored By: Abbott
    56
    MAY 11, 2022 | 12:00 PM
    Conserving California: Applying Whole Genome Sequencing in the California Conservation Genomics Project (CCGP)
    Conserving California: Applying Whole Genome Sequencing in the...
    Date: May 11, 2022 Time: 12:00pm (PDT), 3:00pm (EDT), 9:00pm (CEST) In this presentation, Dr. Courtney Miller and Daniel Rodrigues Oliveira, M.S. will describe the efforts of the California...
    Speaker: Daniel Rodrigues Oliveira, M.S. , Courtney Miller, Ph.D. , Ariele Hanek, Ph.D.
    Sponsored By: seqWell
    15
    DEC 01, 2021 | 9:00 AM
    The Art and Science of Haematology Morphology: RBC Morphology
    The Art and Science of Haematology Morphology: RBC Morphology
    Date: December 1, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The enumeration and analysis of blood cells with automated haematology analysers have significantly improved in recent years due to a...
    Speaker: Daniel Pelling, CSci, FIBMS, DFM
    Sponsored By: Abbott
    32
    SEP 28, 2021 | 9:00 AM
    New method for standardized, high-throughput PBMC isolation from blood samples for observational and clinical studies
    New method for standardized, high-throughput PBMC isolation from...
    Date: September 28, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Standardization and reproducibility are prerequisites for peripheral blood mononuclear cell (PBMC) generation from donor or patient...
    Speaker: Lotta Raty , Dr. Steffen Rapp , PhD
    Sponsored By: Miltenyi Biotec
    10 1
     
     
  • JUN 02, 2021 | 10:00 AM
    Recent advances for simultaneous analysis to determine embryo PGT-A and PGT-M status with NGS
    Recent advances for simultaneous analysis to determine embryo...
    Date: June 2, 2021 Time: 10:00am PDT Preimplantation genetic testing (PGT) is typically performed on a limited number of cells from an embryo biopsy and is used to prioritize embryos for tra...
    Speaker: Cengiz Cinnioglu, PhD
    Sponsored By: Thermo Fisher Scientific
    13
    MAY 05, 2021 | 12:00 AM
    Leveraging Bioinformatic Resources to Better Tackle Challenging Biological Substrates and DNA Profiles
    Leveraging Bioinformatic Resources to Better Tackle Challenging...
    Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
    Speaker: Frank Wendt, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    1
    APR 20, 2021 | 7:30 AM
    C.E. CREDITS
    Keynote Presentation: A structural variation map of 499 Han Chinese individuals using long-read sequencing data
    Keynote Presentation: A structural variation map of 499 Han Chinese...
    Structural variants (SVs) are essential in human evolution and genetic disease but remain understudied. This is especially the case for non-Caucasian ethnicities. We report, for the first ti...
    Speaker: Fritz Sedlazeck, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    1
    FEB 24, 2021 | 12:00 PM
    Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
    Deep Mechanistic profiling of immune oncology drug combinations...
    With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
    Speaker: Jason Frazier , Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: NanoString Technologies
    2
    FEB 24, 2021 | 12:00 AM
    Preclinical evaluation of novel OT-analogs for the potential treatment of social behavioral deficits
    Preclinical evaluation of novel OT-analogs for the potential treatment...
    As pharmaceutical companies have reduced or eliminated neuroscience drug development due to high costs and low approval rates, the economic and healthcare burden of CNS disorders in the Unit...
    Speaker: Marsha Pierce, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    2
     
     
  • DEC 03, 2020 | 12:00 AM
    Recent insights into SARS-CoV-2 intra-host population dynamics
    Recent insights into SARS-CoV-2 intra-host population dynamics
    The fast spread and deadliness of SARS-CoV-2 has sparked much interest in understanding the underlying genomics and evolutionary patterns of this 30,000bp Coronavirus. Since the first report...
    Speaker: Todd Treangen, PhD
    Presented at: Coronavirus Series
    3 1
    NOV 16, 2020 | 5:00 AM
    Diabetes and the Clinical Laboratory
    Diabetes and the Clinical Laboratory
    DATE: November 16, 2020 TIME: 05:00am PST, 2:00pm CET It may be impossible to stop the inexorable move towards pandemic levels of diabetes, but we can improve the glycaemic control in our pa...
    Speaker: Professor Garry John, PhD, FRCPath
    Sponsored By: Abbott Diagnostics
    11 1
    OCT 22, 2020 | 6:05 AM
    NGS for precision oncology in solid tumors: from research to clinical practice
    NGS for precision oncology in solid tumors: from research to clinical...
    Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
    Speaker: Nicola Normanno, MD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 22, 2020 | 6:05 AM
    NGS for precision oncology in solid tumors: from research to clinical practice
    NGS for precision oncology in solid tumors: from research to clinical...
    Precision oncology is revolutionizing the diagnostic and therapeutic approach to cancer. In fact, the availability of tumor-specific and tumor-agnostic biomarkers and matched therapies is ra...
    Speaker: Nicola Normanno, MD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    0
    SEP 23, 2020 | 12:00 AM
    Deep learning to integrate histology with spatial transcriptomics
    Deep learning to integrate histology with spatial transcriptomics
    I will present our new computer vision algorithm, ST-Net, which can computationally synthesize spatially resolved transcriptomics directly from H&E histology images (He et al. Nature Bio...
    Speaker: James Zou
    Presented at: Cell Biology Virtual Event Series 2020
    1
     
     
  • SEP 09, 2020 | 6:00 AM
    Keynote Presentation: Causes and consequences of immune gene diversity in plants
    Keynote Presentation: Causes and consequences of immune gene diversity...
    My group is addressing fundamental questions in evolutionary biology, using both genome- and phenotype-first approaches. A few years ago, we discovered that Arabidopsis thaliana is a great m...
    Speaker: Detlef Weigel, Executive Director
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    SEP 08, 2020 | 11:00 PM
    Deep Learning by Analogy: Applying Text and Image Processing Techniques to Sequence Analysis
    Deep Learning by Analogy: Applying Text and Image Processing Techniques...
    Over the past five years there has been an explosion of research the deep learning field. Companies like Google, Facebook, and OpenAI have created neural networks that are significantly more...
    Speaker: Will Dampier, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    JUN 26, 2020 | 8:00 AM
    Next-Generation Cytogenetics: international, multi-center study of chromosomal aberrations in constitutional diseases and leukemia with Bionano genome imaging
    Next-Generation Cytogenetics: international, multi-center study...
    DATE: June 26, 2020 TIME: 8:00am PT Structural variants (SVs) are an important source of genetic variation in the human genome and they are involved in a multitude of human diseases as well...
    Speaker: Alexander Hoischen , Laila El Khattabi
    Sponsored By: Bionano
    16
    JUN 17, 2020 | 4:30 PM
    Patterns of Intrahost and Interhost variation in SARS-CoV-2
    Patterns of Intrahost and Interhost variation in SARS-CoV-2
    The fast spread of SARS-Cov-2 sparked much interest in understanding the underlying genomics of this 30,000bp Coronavirus. Thus far, thousands of genome assemblies are available, yet they fe...
    Speaker: Todd Treangen, PhD
    Presented at: Coronavirus Series
    1
    MAY 14, 2020 | 2:40 PM
    Oncomine Precision Assay on Ion Torrent Genexus System for liquid biopsy sample
    Oncomine Precision Assay on Ion Torrent Genexus System for liquid...
    Molecular profiling is key in precision oncology research and whilst the tissue testing has become a routine, liquid biopsy might provide a non-invasive alternative when tissue biopsy is ina...
    Speaker: Siew-Kee (Amanda) Low, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    8
     
     
  • MAY 14, 2020 | 2:40 PM
    Oncomine Precision Assay on Ion Torrent Genexus System for liquid biopsy sample
    Oncomine Precision Assay on Ion Torrent Genexus System for liquid...
    The development of molecular targeted therapy is one of the breakthroughs in oncology field. Molecular profiling of the tumor becomes mandatory in the routine clinical practice to select the...
    Speaker: Siew-Kee (Amanda) Low, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    OCT 24, 2019 | 1:30 PM
    Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
    Characterization of Biotherapeutics by Chemometric and Machine...
    With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
    Speaker: Frank Delaglio, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2019
    4 1
    MAY 08, 2019 | 1:30 PM
    Highly Accurate Long Sequence Reads for Comprehensive Genomic Analysis
    Highly Accurate Long Sequence Reads for Comprehensive Genomic...
    Recent improvements in sequencing chemistry and instrument performance combine to create a new PacBio data type of highly accurate (HiFi), long insert reads. Increased read length and improve...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    Sponsored By: PacBio
    2
    NOV 08, 2018 | 5:00 PM
    NMR in standardizing biomarkers for personalized medicine: Where do biobanks come in?  (For research use only)
    NMR in standardizing biomarkers for personalized medicine: Where...
    DATE:  November 9, 2018 TIME:   09:00am CST, 10:00am JST, 12:00pm AEDT Perso and precision medicine are rapidly growing areas that require good data to categoriz...
    Speaker: Matthias Nauck, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    3
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