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    Tumor & Immunity

    Tumors and the immune response interact in various ways. Tumors try to suppress the immune response in an effort to promote their growth and survival. The anti-tumor immune response, on the other hand, identifies tumor cells and kills them. Both tumors and the immune response elicit various mechanisms to combat the actions of the other.

    Webinars

    • JUN 02, 2021 | 12:00 AM
      IFNg-activated dermal lymphatic vessels restrict anti-tumor immunity
      IFNg-activated dermal lymphatic vessels restrict anti-tumor immunity
      Learning Objectives: 1. Define the impact of PD-L1 expressed on non-tumor, non-hematopoietic cells in T cell-mediated tumor control 2. Reveal the contribution of IFNg signaling in dermal lym...
      Speaker: Amanda Lund, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      Engineering universal chimeric antigen receptors (CARs) for cancer therapy
      Engineering universal chimeric antigen receptors (CARs) for cancer...
      Learning Objectives: 1. Define “universal CARs” and describe their mechanism of action. 2. Explain current challenges in CAR T cell therapy. 3. Describe potential benefits and ch...
      Speaker: Jason Lohmueller, Ph.D.
      Presented at: Immuno-Oncology Virtual Event Series 2021
      2
      JUN 02, 2021 | 12:00 AM
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
      Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
      Speaker: Dayana Rivadeneira, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      2
      JUN 02, 2021 | 12:00 AM
      Rational Modifications to CAR Antigen Binding Domain Improve Sensitivity to Low-Density Target Antigens
      Rational Modifications to CAR Antigen Binding Domain Improve Sensitivity...
      Chimeric antigen receptor (CAR) T cells have demonstrated significant success in treating relapsed or treatment-refractory hematologic malignancies in the clinic, inducing remissions in 70-9...
      Speaker: Kole DeGolier, B.S.
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      IDO in Melanoma..... Deserves Further Evaluation
      IDO in Melanoma..... Deserves Further Evaluation
      Learning Objectives: 1. Learn about IDO pathway 2. IDO rule in cancer...
      Speaker: Yousef Zakharia, MD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      EZH2 as an Actionable Therapeutic Target to Enhance Anti-Tumor Immune Response In Prostate Cancer
      EZH2 as an Actionable Therapeutic Target to Enhance Anti-Tumor...
      Prostate cancers are considered immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon st...
      Speaker: Leigh Ellis, Ph.D.
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      Th17-Inducing Vaccines for the Treatment of Ovarian Cancer
      Th17-Inducing Vaccines for the Treatment of Ovarian Cancer
      Ovarian cancer is a deadly disease which is usually diagnosed in advanced stages. Our goal is to develop vaccines to prevent relapse. Natural Th17 T cells protect against recurrence followin...
      Speaker: Keith Knutson, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      Development of FGFR4 targeted Chimeric Antigen Receptors (CARs) for treatment of Rhabdomyosarcoma
      Development of FGFR4 targeted Chimeric Antigen Receptors (CARs)...
      Rhabdomyosarcoma (RMS) is a soft tissue cancer commonly arising in muscle and is the most common soft tissue cancer in children. Patients with metastatic RMS have a poor prognosis that has n...
      Speaker: Peter Sullivan, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      1
      JUN 02, 2021 | 12:00 AM
      Using genetically engineered preclinical models to study T cell therapy against solid tumors
      Using genetically engineered preclinical models to study T cell...
      Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
      Speaker: Leah Schmidt, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      3
      MAY 26, 2021 | 9:00 AM
      Advanced Phenotyping of the Tumor Immune Microenvironment
      Advanced Phenotyping of the Tumor Immune Microenvironment
      Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
      Speaker: Angela Vasaturo, Ph.D. , Fabian Schneider, Ph.D.
      Sponsored By: Ultivue
      6 1
      APR 28, 2021 | 9:00 AM
      Combining protein proximity detection with chromogenic multiplex: Discovering the PD1/PDL1 interactions
      Combining protein proximity detection with chromogenic multiplex:...
      Proximity Ligation Assay (PLA), is a powerful technique for demonstrating the presence of 2 unique targets in direct proximity of each other in tissue sections. It allows visualization of in...
      Speaker: Thierry P.P. van den Bosch, PhD
      Presented at: DISCOVERY Global User Symposium
      3
      APR 21, 2021 | 12:00 AM
      Past, Present and Future of Engineered Cell Therapy
      Past, Present and Future of Engineered Cell Therapy
      Engineered cell therapy is an emerging field of science to target and treat cancer. Current strategies include utilizing immune cells such as T cells, NK cells and Macrophages or other cells...
      Speaker: Janani Krishnamurthy, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      2
      APR 14, 2021 | 12:00 AM
      New Technologies for Accessible, Durable and Broadly Protective Coronavirus Vaccines
      New Technologies for Accessible, Durable and Broadly Protective...
      Over a year into the COVID-19 pandemic, key vulnerable populations in the United States and across the world lack access to effective vaccines. IDRI has developed technology that addresses s...
      Speaker: Corey Casper, M.D., MPH
      Presented at: Coronavirus Series
      20
      APR 08, 2021 | 5:00 PM
      Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional states in immuno-oncology
      Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional...
      DATE: April 08, 2021 TIME: 08:00am PDT Multi-omics involves the use of different data modalities to study multiple “omes”, such as the genome, transcriptome, epigenome, and/or t...
      Speaker: Prof. Abhishek Garg , Dr. Maria Vallejo
      Sponsored By: Miltenyi Biotec
      8
      APR 08, 2021 | 10:00 AM
      Using Single-Cell Multiomics to Accelerate Cancer Immune Cell Therapy Research
      Using Single-Cell Multiomics to Accelerate Cancer Immune Cell...
      Cell therapies, including chimeric antigen receptor (CAR) T-cell therapy, are emerging as promising treatments, especially for hematological malignancies. However, many challenges remain in...
      Speaker: Adriana Suarez, Ph.D.
      Presented at: Advancing CGT: A GENEWIZ & Brooks Life Sciences Virtual Event
      2
      MAR 25, 2021 | 8:00 AM
      Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry Approach to Drug Discovery
      Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry...
      Date: March 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Visikol is a biotechnology company focused on advanced imaging, digital pathology and 3D cell culture assays that has developed a un...
      Speaker: Michael Johnson, PhD
      Sponsored By: Leica Biosystems
      6
      MAR 23, 2021 | 9:00 AM
      Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
      Targeted degradation of the enhancer lysine acetyltransferases...
      Date: March 23, 2021 Time: 9:00am (PST), 12:00pm (EST) The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional reg...
      Speaker: Christopher Ott, PhD , Tim Geiger, PhD
      Sponsored By: ACD - A Bio-Techne Brand
      8
      MAR 09, 2021 | 8:00 AM
      Ultrahigh-content imaging: a breath of fresh air for lung cancer research
      Ultrahigh-content imaging: a breath of fresh air for lung cancer...
      Date: March 09, 2021 Time: 8:00am (PST), 11:00am (EST) Lung cancer is one of the three most common types of cancer. Representing 85% of all lung cancers...
      Speaker: Dr. Telma Santos
      Sponsored By: Miltenyi Biotec
      13
      FEB 24, 2021 | 12:00 PM
      Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
      Deep Mechanistic profiling of immune oncology drug combinations...
      With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
      Speaker: Jason Frazier , Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: NanoString Technologies
      2
      FEB 24, 2021 | 12:00 AM
      Multi-diagnostic approaches for patient selection in immuno-oncology
      Multi-diagnostic approaches for patient selection in immuno-oncology
      The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
      Speaker: Cindy Spittle
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      1
      NOV 19, 2020 | 8:00 AM
      From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
      From discovery to functional assays: therapeutic antibody research...
      Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
      Speaker: Dr. Susanne Bethke
      Sponsored By: Miltenyi Biotec
      9
      November 13, 2020 6:00 PM PST | November 14, 2020 10:00 AM SGT
      Q&A Session (In the RoundTable Room)
      Q&A Session (In the RoundTable Room)
      Visit the RoundTable Room to participate in live Q&A with all the speakers!...
      Speaker: Charalambos C. Solomides, MD , Sara Eglitis, MS, QIHC , Faruk Erdem Kombak, MD , Srabani Bhaumik, PhD , Nelson Alexander, PhD
      Presented at: DISCOVERY Global User Symposium
      0
      November 13, 2020 5:00 PM PST | November 14, 2020 9:00 AM SGT
      Representative sampling to address tumor heterogeneity
      Representative sampling to address tumor heterogeneity
      Ensuring that clinical tests are not affected by tumor heterogeneity requires a sampling methodology that captures the genomic, proteomic, and cellular diversity of entire solid tumors. Howe...
      Speaker: Nelson Alexander, PhD
      Presented at: DISCOVERY Global User Symposium
      2
      November 13, 2020 4:00 PM PST | November 14, 2020 8:00 AM SGT
      Fluorescent multiplexing of 3D spheroid FFPE with Roche automated stainer and reagents: assay optimization, imaging and future implications
      Fluorescent multiplexing of 3D spheroid FFPE with Roche automated...
      Three-dimensional (3D) cell culture spheroids and aggregates are preferred over monolayer cell culture due to their architectural and functional similarity to solid tumors. To study expressi...
      Speaker: Srabani Bhaumik, PhD
      Presented at: DISCOVERY Global User Symposium
      1
    JUN 02, 2021 | 12:00 AM
    IFNg-activated dermal lymphatic vessels restrict anti-tumor immunity
    IFNg-activated dermal lymphatic vessels restrict anti-tumor immunity
    Learning Objectives: 1. Define the impact of PD-L1 expressed on non-tumor, non-hematopoietic cells in T cell-mediated tumor control 2. Reveal the contribution of IFNg signaling in dermal lym...
    Speaker: Amanda Lund, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
    JUN 02, 2021 | 12:00 AM
    Engineering universal chimeric antigen receptors (CARs) for cancer therapy
    Engineering universal chimeric antigen receptors (CARs) for cancer...
    Learning Objectives: 1. Define “universal CARs” and describe their mechanism of action. 2. Explain current challenges in CAR T cell therapy. 3. Describe potential benefits and ch...
    Speaker: Jason Lohmueller, Ph.D.
    Presented at: Immuno-Oncology Virtual Event Series 2021
    2
    JUN 02, 2021 | 12:00 AM
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
    Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
    Speaker: Dayana Rivadeneira, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    2
    JUN 02, 2021 | 12:00 AM
    Rational Modifications to CAR Antigen Binding Domain Improve Sensitivity to Low-Density Target Antigens
    Rational Modifications to CAR Antigen Binding Domain Improve Sensitivity...
    Chimeric antigen receptor (CAR) T cells have demonstrated significant success in treating relapsed or treatment-refractory hematologic malignancies in the clinic, inducing remissions in 70-9...
    Speaker: Kole DeGolier, B.S.
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
    JUN 02, 2021 | 12:00 AM
    IDO in Melanoma..... Deserves Further Evaluation
    IDO in Melanoma..... Deserves Further Evaluation
    Learning Objectives: 1. Learn about IDO pathway 2. IDO rule in cancer...
    Speaker: Yousef Zakharia, MD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
     
     
  • JUN 02, 2021 | 12:00 AM
    EZH2 as an Actionable Therapeutic Target to Enhance Anti-Tumor Immune Response In Prostate Cancer
    EZH2 as an Actionable Therapeutic Target to Enhance Anti-Tumor...
    Prostate cancers are considered immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon st...
    Speaker: Leigh Ellis, Ph.D.
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
    JUN 02, 2021 | 12:00 AM
    Th17-Inducing Vaccines for the Treatment of Ovarian Cancer
    Th17-Inducing Vaccines for the Treatment of Ovarian Cancer
    Ovarian cancer is a deadly disease which is usually diagnosed in advanced stages. Our goal is to develop vaccines to prevent relapse. Natural Th17 T cells protect against recurrence followin...
    Speaker: Keith Knutson, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
    JUN 02, 2021 | 12:00 AM
    Development of FGFR4 targeted Chimeric Antigen Receptors (CARs) for treatment of Rhabdomyosarcoma
    Development of FGFR4 targeted Chimeric Antigen Receptors (CARs)...
    Rhabdomyosarcoma (RMS) is a soft tissue cancer commonly arising in muscle and is the most common soft tissue cancer in children. Patients with metastatic RMS have a poor prognosis that has n...
    Speaker: Peter Sullivan, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    1
    JUN 02, 2021 | 12:00 AM
    Using genetically engineered preclinical models to study T cell therapy against solid tumors
    Using genetically engineered preclinical models to study T cell...
    Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
    Speaker: Leah Schmidt, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    3
    MAY 26, 2021 | 9:00 AM
    Advanced Phenotyping of the Tumor Immune Microenvironment
    Advanced Phenotyping of the Tumor Immune Microenvironment
    Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
    Speaker: Angela Vasaturo, Ph.D. , Fabian Schneider, Ph.D.
    Sponsored By: Ultivue
    6 1
     
     
  • APR 28, 2021 | 9:00 AM
    Combining protein proximity detection with chromogenic multiplex: Discovering the PD1/PDL1 interactions
    Combining protein proximity detection with chromogenic multiplex:...
    Proximity Ligation Assay (PLA), is a powerful technique for demonstrating the presence of 2 unique targets in direct proximity of each other in tissue sections. It allows visualization of in...
    Speaker: Thierry P.P. van den Bosch, PhD
    Presented at: DISCOVERY Global User Symposium
    3
    APR 21, 2021 | 12:00 AM
    Past, Present and Future of Engineered Cell Therapy
    Past, Present and Future of Engineered Cell Therapy
    Engineered cell therapy is an emerging field of science to target and treat cancer. Current strategies include utilizing immune cells such as T cells, NK cells and Macrophages or other cells...
    Speaker: Janani Krishnamurthy, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    2
    APR 14, 2021 | 12:00 AM
    New Technologies for Accessible, Durable and Broadly Protective Coronavirus Vaccines
    New Technologies for Accessible, Durable and Broadly Protective...
    Over a year into the COVID-19 pandemic, key vulnerable populations in the United States and across the world lack access to effective vaccines. IDRI has developed technology that addresses s...
    Speaker: Corey Casper, M.D., MPH
    Presented at: Coronavirus Series
    20
    APR 08, 2021 | 5:00 PM
    Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional states in immuno-oncology
    Generating multi-omics atlas of CD8+ T cell exhaustion vs. dysfunctional...
    DATE: April 08, 2021 TIME: 08:00am PDT Multi-omics involves the use of different data modalities to study multiple “omes”, such as the genome, transcriptome, epigenome, and/or t...
    Speaker: Prof. Abhishek Garg , Dr. Maria Vallejo
    Sponsored By: Miltenyi Biotec
    8
    APR 08, 2021 | 10:00 AM
    Using Single-Cell Multiomics to Accelerate Cancer Immune Cell Therapy Research
    Using Single-Cell Multiomics to Accelerate Cancer Immune Cell...
    Cell therapies, including chimeric antigen receptor (CAR) T-cell therapy, are emerging as promising treatments, especially for hematological malignancies. However, many challenges remain in...
    Speaker: Adriana Suarez, Ph.D.
    Presented at: Advancing CGT: A GENEWIZ & Brooks Life Sciences Virtual Event
    2
     
     
  • MAR 25, 2021 | 8:00 AM
    Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry Approach to Drug Discovery
    Aperio VERSA - Visikol's Highly Multiplexed Immunohistochemistry...
    Date: March 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Visikol is a biotechnology company focused on advanced imaging, digital pathology and 3D cell culture assays that has developed a un...
    Speaker: Michael Johnson, PhD
    Sponsored By: Leica Biosystems
    6
    MAR 23, 2021 | 9:00 AM
    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
    Targeted degradation of the enhancer lysine acetyltransferases...
    Date: March 23, 2021 Time: 9:00am (PST), 12:00pm (EST) The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional reg...
    Speaker: Christopher Ott, PhD , Tim Geiger, PhD
    Sponsored By: ACD - A Bio-Techne Brand
    8
    MAR 09, 2021 | 8:00 AM
    Ultrahigh-content imaging: a breath of fresh air for lung cancer research
    Ultrahigh-content imaging: a breath of fresh air for lung cancer...
    Date: March 09, 2021 Time: 8:00am (PST), 11:00am (EST) Lung cancer is one of the three most common types of cancer. Representing 85% of all lung cancers...
    Speaker: Dr. Telma Santos
    Sponsored By: Miltenyi Biotec
    13
    FEB 24, 2021 | 12:00 PM
    Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
    Deep Mechanistic profiling of immune oncology drug combinations...
    With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
    Speaker: Jason Frazier , Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: NanoString Technologies
    2
    FEB 24, 2021 | 12:00 AM
    Multi-diagnostic approaches for patient selection in immuno-oncology
    Multi-diagnostic approaches for patient selection in immuno-oncology
    The development of different classes of immunotherapies that target cancer cells continues to be a rapidly growing area of research. The development of diagnostic tests which can predict pat...
    Speaker: Cindy Spittle
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    1
     
     
  • NOV 19, 2020 | 8:00 AM
    From discovery to functional assays: therapeutic antibody research by Miltenyi Biotec
    From discovery to functional assays: therapeutic antibody research...
    Date: November 19, 2020 Time: 8:00am PST, 11:00am EST Monoclonal antibody-based drugs have shown great potential as a treatment for several cancers. At Miltenyi Biotec, we offer a complete wo...
    Speaker: Dr. Susanne Bethke
    Sponsored By: Miltenyi Biotec
    9
    November 13, 2020 6:00 PM PST | November 14, 2020 10:00 AM SGT
    Q&A Session (In the RoundTable Room)
    Q&A Session (In the RoundTable Room)
    Visit the RoundTable Room to participate in live Q&A with all the speakers!...
    Speaker: Charalambos C. Solomides, MD , Sara Eglitis, MS, QIHC , Faruk Erdem Kombak, MD , Srabani Bhaumik, PhD , Nelson Alexander, PhD
    Presented at: DISCOVERY Global User Symposium
    0
    November 13, 2020 5:00 PM PST | November 14, 2020 9:00 AM SGT
    Representative sampling to address tumor heterogeneity
    Representative sampling to address tumor heterogeneity
    Ensuring that clinical tests are not affected by tumor heterogeneity requires a sampling methodology that captures the genomic, proteomic, and cellular diversity of entire solid tumors. Howe...
    Speaker: Nelson Alexander, PhD
    Presented at: DISCOVERY Global User Symposium
    2
    November 13, 2020 4:00 PM PST | November 14, 2020 8:00 AM SGT
    Fluorescent multiplexing of 3D spheroid FFPE with Roche automated stainer and reagents: assay optimization, imaging and future implications
    Fluorescent multiplexing of 3D spheroid FFPE with Roche automated...
    Three-dimensional (3D) cell culture spheroids and aggregates are preferred over monolayer cell culture due to their architectural and functional similarity to solid tumors. To study expressi...
    Speaker: Srabani Bhaumik, PhD
    Presented at: DISCOVERY Global User Symposium
    1
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