NOV 24, 2014 12:00 AM PST

Discovery by UCLA researchers could lead to better head and neck cancer therapies

WRITTEN BY: Ilene Schneider
A protein linked to neurological disorders is also associated with head and neck cancer in people who are infected with human papilloma virus, according to a study that was recently published in the Journal of Biological Chemistry. UCLA scientists have discovered that a protein usually linked to rare neurological disorders is also associated with head and neck cancer in people who are infected with the human papilloma virus. When that protein is combined with another cancer-suppressing protein, it helps improve the effectiveness of chemotherapy treatments, said the new study by UCLA researchers.

Head and neck cancer is the sixth-most prevalent form of cancer worldwide. It represents 5 percent of cancers diagnosed annually in the United States. Of the more than 42,000 people diagnosed with head and neck cancer each year, 12,000 will die from the disease.

Human papilloma virus is the most common sexually transmitted infection. HPV diagnoses are at epidemic proportions. The Centers for Disease Control and Prevention estimate that nearly all sexually active men and women will get it at some point in their lives.

HPV can cause cancers in the back of the throat, most commonly in the base of the tongue and tonsils, in an area known as the "oropharynx." These cancers are called "oropharyngeal cancers."

Led by Dr. Eri Srivatsan and Dr. Marilene Wang, UCLA Jonsson Comprehensive Cancer Center members and co-authors of the study, researchers found the link between the protein gigaxonin and head and neck cancer while investigating the chemotherapy drug cisplatin. The drug has been proven successful in killing cancer cells by interacting with the protein p16, which is commonly produced in HPV-positive cancers.

"We studied the interaction of p16 in the nucleus of the cancer cell after treatment with cisplatin and observed how the protein interacted with gigaxonin," said Wang, professor-in-residence of head and neck surgery. "We found that the combination of the proteins stops the cell cycle, allowing chemotherapy treatment to prevent the cell from growing and killing the cancer cell."

For the study, Wang, Srivatsan and eight colleagues at UCLA also analyzed 103 archival clinical samples from head and neck cancer patients to identify the relationship between p16 nuclear expression and cancer-free survival. They found that patients with cancers with p16 expression had better survival rates than without p16 expression.

Though HPV has mostly been seen in cervical cancer, during the past several years there has been an increase in HPV-positive head and neck cancers. These cancers often affect non-smoking younger adults, who previously were not considered to be at high risk for head and neck cancer.

The researchers said they hope that the new findings will lead to an enhanced form of personalized targeted therapy for head and neck cancer patients, ultimately reducing the harsh side effects of chemotherapy and radiation.

"This discovery opens new possibilities in the diagnosis and treatment of HPV-positive head and neck cancers," said Srivatsan, who is a professor of general surgery.
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
MAR 17, 2020
Cancer
MAR 17, 2020
Cancer and the risk of AFib
Research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of ...
APR 02, 2020
Cancer
APR 02, 2020
Diagnosing Cancer: SMOC2 and Thyroid Cancer
  Thyroid cancer is the most common of the endocrine cancers, with papillary thyroid carcinomas (PTCs) being the mo ...
MAY 07, 2020
Cell & Molecular Biology
MAY 07, 2020
How the Function of a Critical Immune Cell is Related to Metabolism
This work suggests that it may be possible to dampen autoimmunity or promote an immune attack on cancer through a bioche ...
MAY 12, 2020
Clinical & Molecular DX
MAY 12, 2020
Could Catching the Flu Be Linked to an Increased Cancer Risk?
Results from a new research study suggest that a spike in infections such as influenza could be linked to the risk of de ...
MAY 26, 2020
Cancer
MAY 26, 2020
Does having a child with cancer increase parents' risk of divorce?
A study from Denmark published in the American Cancer Society journal CANCER reports that having a child with cancer doe ...
MAY 29, 2020
Cancer
MAY 29, 2020
What can we do about drug-induced tetraploidy in cancer cells?
A paper published in the journal Trends in Cancer describes how cancer therapies sometimes fuel genetic changes in cells ...
Loading Comments...