NOV 24, 2014 12:00 AM PST

Discovery by UCLA researchers could lead to better head and neck cancer therapies

WRITTEN BY: Ilene Schneider
A protein linked to neurological disorders is also associated with head and neck cancer in people who are infected with human papilloma virus, according to a study that was recently published in the Journal of Biological Chemistry. UCLA scientists have discovered that a protein usually linked to rare neurological disorders is also associated with head and neck cancer in people who are infected with the human papilloma virus. When that protein is combined with another cancer-suppressing protein, it helps improve the effectiveness of chemotherapy treatments, said the new study by UCLA researchers.

Head and neck cancer is the sixth-most prevalent form of cancer worldwide. It represents 5 percent of cancers diagnosed annually in the United States. Of the more than 42,000 people diagnosed with head and neck cancer each year, 12,000 will die from the disease.

Human papilloma virus is the most common sexually transmitted infection. HPV diagnoses are at epidemic proportions. The Centers for Disease Control and Prevention estimate that nearly all sexually active men and women will get it at some point in their lives.

HPV can cause cancers in the back of the throat, most commonly in the base of the tongue and tonsils, in an area known as the "oropharynx." These cancers are called "oropharyngeal cancers."

Led by Dr. Eri Srivatsan and Dr. Marilene Wang, UCLA Jonsson Comprehensive Cancer Center members and co-authors of the study, researchers found the link between the protein gigaxonin and head and neck cancer while investigating the chemotherapy drug cisplatin. The drug has been proven successful in killing cancer cells by interacting with the protein p16, which is commonly produced in HPV-positive cancers.

"We studied the interaction of p16 in the nucleus of the cancer cell after treatment with cisplatin and observed how the protein interacted with gigaxonin," said Wang, professor-in-residence of head and neck surgery. "We found that the combination of the proteins stops the cell cycle, allowing chemotherapy treatment to prevent the cell from growing and killing the cancer cell."

For the study, Wang, Srivatsan and eight colleagues at UCLA also analyzed 103 archival clinical samples from head and neck cancer patients to identify the relationship between p16 nuclear expression and cancer-free survival. They found that patients with cancers with p16 expression had better survival rates than without p16 expression.

Though HPV has mostly been seen in cervical cancer, during the past several years there has been an increase in HPV-positive head and neck cancers. These cancers often affect non-smoking younger adults, who previously were not considered to be at high risk for head and neck cancer.

The researchers said they hope that the new findings will lead to an enhanced form of personalized targeted therapy for head and neck cancer patients, ultimately reducing the harsh side effects of chemotherapy and radiation.

"This discovery opens new possibilities in the diagnosis and treatment of HPV-positive head and neck cancers," said Srivatsan, who is a professor of general surgery.
About the Author
Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
AUG 02, 2022
Cell & Molecular Biology
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
AUG 02, 2022
A New, Innovative Process for Clarifying and Sterile Filtering Cells for Protein Purification Workflows
Introduction Centrifugation and filtration have been widely accepted as techniques required for clarifying complex cell ...
AUG 12, 2022
Immunology
Study Suggests that Terminally Exhausted T cells can be Rejuvenated
AUG 12, 2022
Study Suggests that Terminally Exhausted T cells can be Rejuvenated
Our immune cells can target cancer, but T cells can become worn out and exhausted  during lengthy battles, and they ...
SEP 19, 2022
Cancer
Smoking Cessation Impacted by the COVID Pandemic
SEP 19, 2022
Smoking Cessation Impacted by the COVID Pandemic
Smoking remains a major risk factor for several types of cancer.  While the association between lung cancer and smo ...
OCT 17, 2022
Clinical & Molecular DX
New Study Shows Biological Differences in the Second-Most Common Type of Breast Cancer
OCT 17, 2022
New Study Shows Biological Differences in the Second-Most Common Type of Breast Cancer
Though invasive lobular carcinoma (ILC) is the second-most common type of breast cancer, it has historically been resear ...
NOV 09, 2022
Genetics & Genomics
Want to Study Copy Number Alterations in Cells? Bring MACHETE
NOV 09, 2022
Want to Study Copy Number Alterations in Cells? Bring MACHETE
Sure, MACHETE is a cool name, but the researchers that developed the technique are hoping people don't focus solely on t ...
NOV 17, 2022
Cancer
Anti-Aging Supplement Linked to Aggressive Breast Cancer
NOV 17, 2022
Anti-Aging Supplement Linked to Aggressive Breast Cancer
Vitamin B3, also known as niacin, is a generic name for a group of biochemical compounds, including nicotinamide ribosid ...
Loading Comments...