JUN 03, 2017 9:06 AM PDT

Why Does Fish Oil Stop Lupus?

WRITTEN BY: Xuan Pham

Sometimes scientists have to work in reverse. That is, they may know that a compound seems to treat a disease, but then they have to work backwards to understand exactly how the drug acts on the body. Such is the case with lupus and omega-3 fatty acid, or DHA. The compound is effective at stopping lupus, but not much is known about the why and the how. And scientists at Michigan State University intend on answering these questions with the $2.3 million grant from the National Institute of Health.

Image credit: pixabay.com

"Lupus is the body's immune system attacking itself and it can damage any part of the body including skin, joints and organs," explained Dr. James Pestka, a University Distinguished Professor of food science and human nutrition. "This new research will let us see what happens at the cellular level in the triggering of lupus and how we can intervene nutritionally with DHA to prevent the flaring and progression of the disease."

The disease affects an estimated 5 million people worldwide. Some forms of the disease have genetic underpinnings, and other forms are brought on by environmental stressors, like infections and exposure to certain medications. In particular, Pestka and his team are focused on the lupus associated with inhalation of silica, a toxic mineral. Several studies previously linked occupational exposure to crystalline silica and risk of developing systemic lupus erythematosus, the most common and serious form of the disease.

Previous research also show that this type of lupus seemed to be treatable with omega-3 fatty acids, also known as docosahexaenoic acid (DHA). This fat is found primarily in fish, and is often praised for its health benefits. Indeed, DHA has been linked to lowering the risk of heart disease, rheumatoid arthritis, and depression. The compound is even added to prenatal supplements as research shows it’s important for a baby’s visual and neurological developments.

"When lupus is triggered by fine inhalable particles called crystalline silica in the lungs, our earlier research has shown that DHA essentially stopped the activation of the disease," said Pestka.

Why is this the case? Some researchers hypothesize that DHA may signal the cells to ingest the toxic silica particles, and thereby preventing a systemic inflammatory reaction by the body. But Pestka’s co-investigator, Jack Harkema, disagrees with this idea. "Cells in the lung can gobble up the silica, but it's so toxic, it usually kills these cells," Harkema said. "When they die, signals are sent out to the immune system that something is wrong. The body then produces such a strong response that it also starts killing healthy cells."

The team didn’t let on the hypothesis they’ll be testing. However, they hope this investigation will shed light on how other respiratory substances can trigger the disease, and what other compounds may quell the lupus reaction.

Additional source: Michigan State University

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
DEC 23, 2019
Technology
DEC 23, 2019
Can Artifical Intelligence Detect Leukemia?
Artificial intelligence has always been a hot topic of discussion in the medical sciences with a whirlwind of applications. However, know the latest curios...
JAN 07, 2020
Clinical & Molecular DX
JAN 07, 2020
Saliva Test for Early Detection of Mouth and Throat Cancer
“OPC is one of the fastest rising cancers in Western countries due to increasing HPV-related incidence, especially in younger patients. It is paramou...
JAN 13, 2020
Cancer
JAN 13, 2020
The anti-cancer properties of bitter melon
New research published in the journal Cell Communication and Signaling suggests that bitter melon, also known as bitter gourd, may have anti-cancer propert...
JAN 15, 2020
Cell & Molecular Biology
JAN 15, 2020
Cell Division Research Reveals More About a Protein That's Elevated in Cancer
Cell division is a carefully regulated process, cancer is the result when it gets out of control....
JAN 21, 2020
Cancer
JAN 21, 2020
A gene for leukemia triggers the growth of stem blood cells
New research from the University of Colorado Cancer Center has identified a way to make hematopoietic stem cells from a gene that causes a type of leukemia...
FEB 11, 2020
Cancer
FEB 11, 2020
Could we be over-diagnosing cancer?
Roughly one in every two people are estimated to receive a cancer diagnosis at some point in their lives, but are all of those diagnoses valid? New researc...
Loading Comments...