JUN 06, 2016 8:16 AM PDT

Free Website to Study Metabolism and Genes Now Online

WRITTEN BY: Carmen Leitch
A web service named GAM (Genes and Metabolites) by its developers is now available to the public for use. The program was created by an international group of researchers from the United States, Canada, Russia and Germany and aims to help scientists analyze intricate biological functions in cells. Publicized in a study published in Nucleic Acids Research, the website can identify links between modifications in genes and metabolism to aid in understanding how metabolic regulation affects cellular processes and genetic changes.
        A sample map of metabolic pathways
Senior author of the publication Maxim Artyomov, an Assistant Professor at Washington University in St. Louis, said “Our service is a helping hand to many biologists and immunologists who investigate the effects of metabolism on clinical changes. In previous studies, we confirmed experimentally how well our algorithm performs. A large number of research groups turned to us for the help and Alexey Sergushichev from ITMO University in Saint Petersburg, Russia has created a web service, so that scientists from all over the world have easy access to this method.”

In a mammalian cell, 1,500 interrelated chemical reactions could be happening at any one moment. That makes modeling biological processes immensely complicated and challenging and until now, no such effective computational service existed for free.
        A conceptual flowchart of how the website works
As a sort of proof of concept, the group had tested the algorithm in a study of cancer cells; they were able to demonstrate that inhibiting some metabolic processes in cancer cells can delay tumor growth.

The immune system is another part of physiology that is appreciably influenced by gene expression. "Metabolic pathways incorporate enzymes that catalyze chemical reactions. These enzymes are encoded by specific genes. Using our web service, one can analyze changes not only in metabolite concentrations but also in gene expression. Thus, we can understand the mechanisms of cellular processes and to identify key reactions in the course of various autoimmune diseases. In the future, it will aid the development of immune system regulators, for example, immune suppressors for the effective treatment of such pathologies as diabetes mellitus type I or chronic hepatitis B, which are caused by the immune system disorders," said Alexey Sergushichev.
 
The program works by comparing data on gene expression and metabolite concentrations to a KEGG database in which a baseline for biological processes is established. Cellular functions can then be identified through analysis of the reference, or normal, state and compared to one under the influence of an external factor.

On one hand, the method is excellent for analyzing a network of reactions when scientists don’t know what patterns they are looking for. On the other hand, it helps detect signaling agents that transmit information about metabolic changes, and to study their role in intracellular processes. Parallel analysis of metabolite concentration and gene expression can narrow a search area and make a convoluted network of reactions understandable and readable for researchers.

Scientists can use it now, without needing access to special software.
 
Sources: ITMO University, Nucleic Acid Research
 
About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
DEC 24, 2020
Genetics & Genomics
After Chromosomes Shatter, Cancer Cells Can Become Drug-Resistant
DEC 24, 2020
After Chromosomes Shatter, Cancer Cells Can Become Drug-Resistant
Many types of cells have to be replenished throughout our lives, and cells divide to replace those that are damaged or w ...
JAN 05, 2021
Cell & Molecular Biology
Brown Fat Appears to Protect Against Disease
JAN 05, 2021
Brown Fat Appears to Protect Against Disease
Not all fat is the same. White fat is what we're usually thinking of when we think of flabby tissue that stores excess c ...
JAN 12, 2021
Cell & Molecular Biology
Hyperactive Mitochondria Can Fuel Brain Tumors
JAN 12, 2021
Hyperactive Mitochondria Can Fuel Brain Tumors
The most common and deadly form of brain cancer is known as glioblastoma; the median survival time for patients is only ...
JAN 28, 2021
Cell & Molecular Biology
Gene Variants Affecting an Ion Channel Alter Parkinson's Disease Risk
JAN 28, 2021
Gene Variants Affecting an Ion Channel Alter Parkinson's Disease Risk
These variants can raise, or lower the risk of the disease, and now researchers have learned how they work.
FEB 09, 2021
Cell & Molecular Biology
Brain Cells Called Astrocytes Linked to Depression
FEB 09, 2021
Brain Cells Called Astrocytes Linked to Depression
Depression is thought to affect at least 264 million people of all ages worldwide, and the available treatment options d ...
FEB 24, 2021
Cell & Molecular Biology
Ancient Fungi Found in Europe's Largest Impact Crater
FEB 24, 2021
Ancient Fungi Found in Europe's Largest Impact Crater
Long ago, fungi colonized the impact crater of an ancient meteor. It seems they may have begun working in partnership wi ...
Loading Comments...