MAY 18, 2018 4:29 PM PDT

Likely Cause of Polycystic Ovarian Syndrome ID'ed

WRITTEN BY: Carmen Leitch

Polycystic ovary syndrome (PCOS) is a leading cause of infertility in women and can be a cause of miscarriage. Now research has identified a possible cause of this disorder, which has been unknown. Scientists from the French National Institute of Health and Medical Research have found that overexposure to a molecule called anti-Mullerian hormone, or AMH, leads to PCOS in a mouse model. The work has been reported in Nature Medicine and is briefly outlined in the video.

In women affected by PCOS, multiple cysts grow on the ovaries; they have irregular periods and might have trouble getting pregnant. It is found in women that also have high levels of male hormones, which can lead to excess hair growth on the body and face. 

The treatments for the disease have a host of nasty side effects; there are risks for cardiovascular disease, type 2 diabetes, and infertility. 

The scientists posited that when a fetus is exposed to high levels of AMH, it disrupts signals coming from the GnRH receptor. That leads to the symptoms seen in PCOS, and also presents a new therapeutic target for drug development.

The image shows a mouse ovary with proteins specific to oocytes labelled in red and yellow. / Credit: Schimenti Lab, Cornell University

The investigators found that pregnant women that have PCOS also have levels of AMH that are 30 percent higher than they should be. The disorder tends to cluster in families, so the researchers thought that the hormone might have something to do with the development of the disorder.

They used pregnant mice to show that fetuses that are exposed to high levels of AMH will develop PCOS. The mice in their study had a delayed onset of puberty, ovulated infrequently, got pregnant later and had fewer pups than unaffected mice, which are all signs of the disorder.

Intriguingly, the scientists were able to reverse the symptoms of the disease in mice when they used the drug cetrorelix, an IVF medication.

"It could be an attractive strategy to restore ovulation and eventually increase the pregnancy rate in these women," commented lead author Dr. Paolo Giacobini, to New Scientist.

The researchers think this may be why finding a genetic cause for PCOS has been so elusive. They also hope to begin drug trials by the end of the year to test its efficacy in people.

Sources: New Scientist, Mayo Clinic, Nature Medicine

About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
FEB 27, 2021
Cell & Molecular Biology
It's Now Possible to Measure tRNA Levels in Cells
FEB 27, 2021
It's Now Possible to Measure tRNA Levels in Cells
There are different kinds of ribonucleic acids that play essential roles in many aspects of molecular biology, including ...
MAR 03, 2021
Microbiology
Study May Explain Higher Flu Risk in Adults That Were Premature Babies
MAR 03, 2021
Study May Explain Higher Flu Risk in Adults That Were Premature Babies
Medical treatments for the care of premature babies have allowed many individuals to get through that challenge and lead ...
MAR 08, 2021
Microbiology
Researchers Discover a New Symbiosis
MAR 08, 2021
Researchers Discover a New Symbiosis
A new type of endosymbiosis has been discovered; the organisms are shown in this image by S. Ahmerkamp, Max Planck Insti ...
MAR 25, 2021
Genetics & Genomics
Sperm's Molecular 'Memory' Is Revealed
MAR 25, 2021
Sperm's Molecular 'Memory' Is Revealed
The human genome contains the genes that make us who we are, because of how and when those genes are expressed. Gene exp ...
MAR 26, 2021
Cell & Molecular Biology
New 'Bio-ink' Gets 3D-Printed Organs Closer to Reality
MAR 26, 2021
New 'Bio-ink' Gets 3D-Printed Organs Closer to Reality
For the many people waiting for transplants, 3D-printed organs can't come soon enough. Researchers have been making stri ...
APR 21, 2021
Microbiology
An Unknown Unknown - What's the State of Microbial Biodiversity?
APR 21, 2021
An Unknown Unknown - What's the State of Microbial Biodiversity?
Researchers have noted that we have a 'profound ignorance' about the state of the microbial populations of the world.
Loading Comments...