FEB 01, 2019 10:11 PM PST

Re-purposing Anti-rejection Drug for Liver Cancers

WRITTEN BY: Nouran Amin

Scientists at the University of Pittsburgh School of Medicine have identified a molecular pathway in liver that can allow an anti-rejection drug to be repurposed for the treatment of certain liver cancers. "Current liver cancer therapies increase the likelihood of survival only by 3 or 4 months, so taking a precision medicine approach to identify the right patient could allow us to repurpose existing drugs to improve treatment success," says Satdarshan Monga, M.D., professor of pathology and founding director of the Pittsburgh Liver Research Center at Pitt's School of Medicine.

Learn more about liver cancers:

"What we've found is that liver cancers with a specific mutation in the β-catenin gene are possibly more susceptible to rapamycin, a commonly used anti-rejection medication in transplantation," says Monga. "We think this gives us a new precision medicine approach to develop therapies for liver cancer, which often are very resistant to treatment."

These are mouse liver tissues showing cells surrounding the central vein with active mTOR (red) and glutamine synthetase (green) being present in the same cells (yellow).

Credit: Cell Reports/University of Pittsburgh

Investigation of the molecular pathway began with measurements of high levels of a protein called mTOR--a nutrition and energy sensor crucial to cellular metabolism. The protein was present in the same cells where β-catenin was known to be active. This encouraged the researchers to see if the two proteins were functionally linked by creating a mouse model of liver cancer. They added a drug called rapamycin, a known immunosuppressant of mTOR, and found that the tumors decreased in size. This confirmed that mTOR palsy a major role in cancer growth of the liver. "I like to say these tumors are mTOR addicted," said Monga, who is senior author of the study as well as an investigator at the McGowan Institute of Regenerative Medicine and the UPMC Hillman Cancer Center. "Activating mTOR kicks up the protein-making factories in these cells, giving them the resources to divide and grow."

Results of the study were published in Cell Metabolism.

Source: Science Daily

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
OCT 13, 2019
Cancer
OCT 13, 2019
Using VR to Design Medicine
Being able to visualize and precisely understand molecular shapes is a key factor in drug design. Over the years, to envision and better understand molecul...
OCT 13, 2019
Health & Medicine
OCT 13, 2019
High Risk: Seizures and Coma Linked to Use of Synthetic Cannabinoids in Adolescents
A recent study by the American Academy of Pediatrics states that exposure to acute synthetic cannabinoid toxicity is far more dangerous to the adolesc...
OCT 13, 2019
Health & Medicine
OCT 13, 2019
Ketamine is not an opioid, and treats depression in a novel way
In March, the U.S. Food and Drug Administration approved ketamine nasal spray to treat depression. Ketamine has gotten a bad rep as an opioid - which it is...
OCT 13, 2019
Chemistry & Physics
OCT 13, 2019
Chemists Synthesized Effective Antidote For Uranium Poisoning
Uranium poisoning is unusual to the general population but does happen to miners, mineral mill and fabrication workers. Through inhaling and ingestion, ura...
OCT 13, 2019
Drug Discovery & Development
OCT 13, 2019
Does Modafinil Really Increase Brain Function?
Modafinil, often sold under the name “Provigil”, is a wakefulness-promoting drug used to treat excessive sleeping in conditions such as narcole...
OCT 13, 2019
Drug Discovery & Development
OCT 13, 2019
Does Adderall Really Work for People without ADHD?
Adderall is a popular stimulant. Known to treat Attention Deficit Disorder (ADHD), those without the condition also use it to increase attention, focus and...
Loading Comments...