SEP 19, 2019 12:40 PM PDT

Transplanted Brain Stem Cells Survive Without Anti-Rejection Drugs

WRITTEN BY: Nouran Amin

Researchers at Johns Hopkins Medicine have successfully transplanted brain cells without the need of immune-suppressing drugs. Findings of the study were published in the journal Brain which describes the newest approach in selectively circumventing immune responses against transplanted cells. The study serves as the basis for future therapeutic studies that may award renewed hope.

For example, every year approximately 1 of 100,000 children born in the U.S. will be born to a rare genetic disease such as Pelizaeus-Merzbacher disease that is characterized by infants missing developmental marks like sitting and walking, having involuntary muscle spasms, and the possibility of experiencing partial paralysis of the arms and legs, all caused by a genetic mutation in the genes that form myelin.

"Because these conditions are initiated by a mutation causing dysfunction in one type of cell, they present a good target for cell therapies, which involve transplanting healthy cells or cells engineered to not have a condition to take over for the diseased, damaged or missing cells," says Piotr Walczak, M.D., Ph.D., associate professor of radiology and radiological science at the Johns Hopkins University School of Medicine.

Learn more about transplantation rejection:

Researchers have pursued ways to alter T cells--the system's elite infection-fighting force that attacks foreign invaders. "These signals are in place to help ensure these immune system cells do not go rogue, attacking the body's own healthy tissues," says Gerald Brandacher, M.D., professor of plastic and reconstructive surgery and scientific director of the Vascularized Composite Allotransplantation Research Laboratory at the Johns Hopkins University School of Medicine and co-author of this study.

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
MAY 08, 2020
Drug Discovery & Development
MAY 08, 2020
Cholesterol Drugs May Boost Healthy Gut Bacteria in Obese People
While statins have long been known for their efficacy in treating high cholesterol, until recently, there was no evidenc ...
MAY 14, 2020
Immunology
MAY 14, 2020
Antibody-laden Nanoparticles to Help COVID Patients Breathe Easy
Antibodies are a powerful countermeasure against COVID-19. Not only can they relieve symptoms in patients experiencing s ...
JUN 09, 2020
Drug Discovery & Development
JUN 09, 2020
Arthritis Drug May Reduce COVID-19 Deaths by 45%
Researchers from the University of Michigan have found that tocilizumab, an immunosuppressive drug used to treat arthrit ...
JUN 10, 2020
Cannabis Sciences
JUN 10, 2020
Cannabis Temporarily Relieves PTSD Symptoms
PTSD (Post Traumatic Stress Disorder) is a mental disorder characterized by flashbacks, nightmares, and severe anxiety f ...
JUL 01, 2020
Cancer
JUL 01, 2020
The MicroRNA That Can Regulate Tumor Vascularization in Liver Cancer
Angiogenesis is the vascularization, or generation of blood vessels, of a part of the body. It is a normal function of h ...
JUL 05, 2020
Drug Discovery & Development
JUL 05, 2020
New Drug May Reduce Inflammation from COVID-19
Scientists from the University of Toronto have identified a new drug candidate that may reduce all kinds of inflammation ...
Loading Comments...