OCT 21, 2019 10:32 PM PDT

Therapeutic Targets Inflammation Associated with Genetic Heart Disease

WRITTEN BY: Nouran Amin

Often times when young athletes collapse during the game it is due to sudden cardiac death as a result of the inherited arrhythmogenic cardiomyopathy (ACM). Researchers have sought a new drug that can help reduce some of the ACM disease symptoms and progression to heart failure in affected individuals. The drug is referred to as ‘Bay-11-7082’ and is currently used in laboratory settings for experimental purposes.

Learn more:

"We realized that heart muscle inflammation in ACM is much more complicated than we thought, but also might provide a therapeutic strategy," says Stephen Chelko, Ph.D., assistant professor of medicine at the Johns Hopkins University School of Medicine.

ACM patients carry mutations in any of the five genes that are involved with holding the heart cells together. If an individual is aware that they carry such mutations, they are warned to avoid certain exercises and are placed on particular diets. Although some drugs are prescribed to maintain a slower heart rate, there are currently none that target the underlying defects of ACM.

"We tended in the past to view ACM as something that kills due to a sudden arrhythmic event," said Chelko. "But now we're starting to also see it as a chronic inflammatory disease that can progress more slowly over time, leading to heart failure."

Researchers have examined the molecular origins of heart inflammation in people with ACM. Findings, published in Circulation, shows that inflammation is a result of two separate causes: the high levels of an immune cell known as macrophages, a type of immune cell that's normally found at sites of inflammation and the presence of protein nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

A healthy mouse heart (left), a mouse heart with cardiomyopathy (center) and a mouse heart with cardiomyopathy treated with the NF-κB-blocking drug Bay-11-7082 (right).

Credit: Circulation via HopkinsMedicine.org

"Macrophages are usually the good guys who help heal a wound and then leave," said Chelko. "But in ACM they're permanently setting up shop in the heart, which, over time, reduces its function. We're very excited to have found an FDA-approved drug that can reduce heart inflammation in ACM, and we're eager to do more research to ultimately help those who carry these genetic mutations.”

Story Source: Johns Hopkins Medicine

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
MAY 03, 2021
Drug Discovery & Development
Low Dose Radiation May Improve Symptoms of Alzheimer's
MAY 03, 2021
Low Dose Radiation May Improve Symptoms of Alzheimer's
While high doses of radiation are known to be harmful, low doses may be able to help the body protect and repair. And no ...
MAY 15, 2021
Neuroscience
Eye Scans May Indicate Early Signs of Alzheimer's
MAY 15, 2021
Eye Scans May Indicate Early Signs of Alzheimer's
Researchers from the University of California San Francisco have found that retinal scans can detect changes in blood ve ...
MAY 25, 2021
Cell & Molecular Biology
A simplified high-throughput protein expression system
MAY 25, 2021
A simplified high-throughput protein expression system
Protein synthesis, protein engineering, and synthetic biology researchers can research their protein of interest using e ...
JUN 03, 2021
Immunology
Inhalable Anti-COVID Nanobodies Show Promising Results in Hamsters
JUN 03, 2021
Inhalable Anti-COVID Nanobodies Show Promising Results in Hamsters
Nanobodies are small fragments of monoclonal antibodies that from a therapeutic perspective are more stable and cheaper ...
JUL 18, 2021
Drug Discovery & Development
COVID-19 Antibiotic No More Effective than Placebo
JUL 18, 2021
COVID-19 Antibiotic No More Effective than Placebo
Azithromycin, a broad-spectrum antibiotic commonly used to prevent symptoms of COVID-19 in non-hospitalized patients, do ...
JUL 27, 2021
Immunology
Rethinking Immune Responses Involved in Skin Hypersensitivity
JUL 27, 2021
Rethinking Immune Responses Involved in Skin Hypersensitivity
A study by immunologists at the University of Copenhagen has revealed a never-before-seen immune pathway invol ...
Loading Comments...