DEC 16, 2019 9:23 AM PST

IV Treatment for Traumatic Brain Injury

WRITTEN BY: Nouran Amin

Scientists are now using exosomes intravenously as a method of cell-to-cell technology for treating patients with traumatic brain injury (TBI). They discovered that exosomes inside brain cells carry messages to the brain and can reduce and possibly avert the development of TBI. Findings of the study, published in Neurotrauma, outlines the steps in industry development and commercial manufacturing of the first regenerative TBI-IV treatment therapy.

“The technology takes full benefit of the desirable properties of a neural stem cell therapy without introducing cells into patients,” said Steven Stice, Georgia Research Alliance Eminent Scholar and D.W. Brooks Distinguished Professor in the College of Agricultural and Environmental Sciences. “We are working toward a therapeutic that has a multifunctional promise to repair brain injury and be producible in a cost-effective, off-the-shelf drug format.”

The technology contains bio-manufactured exosomes that can be stored at room temperature and injected to the vein when needed. Once in the body, the exosomes become message mediators between other cells. The efficacy and safety of the technology was tested in rats and was shown to improve brain functionally after a TBI.

“Mechanistically, TBI is a physician’s nightmare,” said Lohitash Karumbaiah, associate professor of regenerative medicine in UGA’s College of Agricultural and Environmental Sciences and one of the publication’s lead authors. “Because there are so many things going on in the brain, you can’t really exactly pinpoint what is going wrong, and without therapies to immediately improve recovery, the situation becomes extremely complex.”

Traumatic brain injuries have a differing amount of symptoms according to the severity of the injury and thus, may pose challenging to detect. Therefore, researchers are hopeful that the novel treatment can be administered immediately when a TBI occurs.

Learn more about traumatic brain injuries (TBI):

“Administrating exosomes into a patient’s IV drip would always be preferable to invasive brain surgery,” Karumbaiah said. “What we can do is give physicians a fighting chance to regulate the inflammatory response of TBI, rather than trying to treat it after it occurs.”

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
APR 15, 2021
Drug Discovery & Development
Magic Mushroom Therapy and Antidepressants Produce Similar Results
APR 15, 2021
Magic Mushroom Therapy and Antidepressants Produce Similar Results
In recent years, psilocybin (the psychoactive ingredient in 'magic mushrooms') has gained increasing amounts of ...
APR 24, 2021
Drug Discovery & Development
Lithium Treats Intellectual Disabilities in Mice
APR 24, 2021
Lithium Treats Intellectual Disabilities in Mice
Mouse models of Bardet-Biedl Syndrome (BBS) have a challenge with learning as a result of dysfunctional neuronal systems ...
MAY 31, 2021
Immunology
Engineering Faster, More Agile T Cell Cancer Fighters
MAY 31, 2021
Engineering Faster, More Agile T Cell Cancer Fighters
Cell therapies use engineered T cells extracted from the patient’s own immune system to rally an attack on tumors. ...
JUN 29, 2021
Microbiology
Gut Fungi May Be an Untapped Reservoir of Antibiotics
JUN 29, 2021
Gut Fungi May Be an Untapped Reservoir of Antibiotics
Viruses are not the only microbes that can cause serious public health problems. Researchers have been warning about a p ...
JUL 15, 2021
Cannabis Sciences
Cannabis Terpenes Provide Pain Relief in Mice
JUL 15, 2021
Cannabis Terpenes Provide Pain Relief in Mice
Cannabis terpenes, the part of cannabis plants responsible for its smell and taste, may be able to relieve pain both by ...
JUL 16, 2021
Drug Discovery & Development
Machine Learning Ranks Cancer Drugs by Efficacy
JUL 16, 2021
Machine Learning Ranks Cancer Drugs by Efficacy
A machine learning algorithm developed by researchers at the Queen Mary University of London in the UK can rank cancer d ...
Loading Comments...