DEC 16, 2019 9:23 AM PST

IV Treatment for Traumatic Brain Injury

WRITTEN BY: Nouran Amin

Scientists are now using exosomes intravenously as a method of cell-to-cell technology for treating patients with traumatic brain injury (TBI). They discovered that exosomes inside brain cells carry messages to the brain and can reduce and possibly avert the development of TBI. Findings of the study, published in Neurotrauma, outlines the steps in industry development and commercial manufacturing of the first regenerative TBI-IV treatment therapy.

“The technology takes full benefit of the desirable properties of a neural stem cell therapy without introducing cells into patients,” said Steven Stice, Georgia Research Alliance Eminent Scholar and D.W. Brooks Distinguished Professor in the College of Agricultural and Environmental Sciences. “We are working toward a therapeutic that has a multifunctional promise to repair brain injury and be producible in a cost-effective, off-the-shelf drug format.”

The technology contains bio-manufactured exosomes that can be stored at room temperature and injected to the vein when needed. Once in the body, the exosomes become message mediators between other cells. The efficacy and safety of the technology was tested in rats and was shown to improve brain functionally after a TBI.

“Mechanistically, TBI is a physician’s nightmare,” said Lohitash Karumbaiah, associate professor of regenerative medicine in UGA’s College of Agricultural and Environmental Sciences and one of the publication’s lead authors. “Because there are so many things going on in the brain, you can’t really exactly pinpoint what is going wrong, and without therapies to immediately improve recovery, the situation becomes extremely complex.”

Traumatic brain injuries have a differing amount of symptoms according to the severity of the injury and thus, may pose challenging to detect. Therefore, researchers are hopeful that the novel treatment can be administered immediately when a TBI occurs.

Learn more about traumatic brain injuries (TBI):

“Administrating exosomes into a patient’s IV drip would always be preferable to invasive brain surgery,” Karumbaiah said. “What we can do is give physicians a fighting chance to regulate the inflammatory response of TBI, rather than trying to treat it after it occurs.”

Source: Science Daily

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUN 16, 2020
Microbiology
A Bacterial Compound Could Become a Treatment for Parasitic Infections
JUN 16, 2020
A Bacterial Compound Could Become a Treatment for Parasitic Infections
The World Health Organization has estimated that parasitic infections cause over 48 million cases of illness and 59,000 ...
JUL 05, 2020
Neuroscience
Iron Build-up in Brain Linked to Alzheimer's
JUL 05, 2020
Iron Build-up in Brain Linked to Alzheimer's
Researchers from the Medical University of Graz in Austria have found a link between the build-up of iron in the brain&# ...
JUL 20, 2020
Neuroscience
Phantom-Limb Pain Reduced by Brain-Computer Interface
JUL 20, 2020
Phantom-Limb Pain Reduced by Brain-Computer Interface
Phantom-limb pain is a condition in which amputees feel like their amputated limb is still attached to their bodies. Whi ...
JUL 26, 2020
Drug Discovery & Development
AI Creates Proteins that Rival Those in Nature
JUL 26, 2020
AI Creates Proteins that Rival Those in Nature
Proteins are crucial for the function of cells in living organisms. Now, researchers have developed a machine leaning-le ...
JUL 21, 2020
Drug Discovery & Development
New Drug Discoveries are Due To Good Labs
JUL 21, 2020
New Drug Discoveries are Due To Good Labs
A study suggests that the quality of lab procedures performed heavily influences the rate of drug discoveries. These fin ...
JUL 30, 2020
Drug Discovery & Development
Cats Successfully Treated with Gene Therapy
JUL 30, 2020
Cats Successfully Treated with Gene Therapy
While gene therapy is a promising treatment for multiple diseases caused by a genetic mutation, getting gene therapy age ...
Loading Comments...