SEP 11, 2020 6:39 PM PDT

Novel Therapeutic for ALS

WRITTEN BY: Nouran Amin

The TDP-43 protein is a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A pre-clinical study found that an investigational drug may target the particular hallmark protein.

"A common genetic cause of ALS and FTD is a repeat expansion in the C9orf72 gene, which somehow leads to TDP-43 aggregation in degenerating neurons, but what remained unclear until now was how those two were connected," said co-senior author James Shorter, PhD, a professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania. "We found that TDP-43 aggregates much more rapidly if these toxic poly(GR) proteins are around, suggesting a direct link between the mutation, poly(GR), and TDP-43."

Learn more about amyotrophic lateral sclerosis (ALS):

Findings were published in Science Translational Medicine.

"This finding presents an exciting potential therapeutic target to treat these debilitating diseases by lowering poly(GR) levels," added Hana Odeh, PhD, a post-doctoral fellow in the Shorter lab and co-first author.

Source: Science Daily

About the Author
  • Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
NOV 23, 2021
Infographics
The Health Benefits of Cannabis
NOV 23, 2021
The Health Benefits of Cannabis
Legislation is opening more and more doors for cannabis- causing an explosion in both research and marketing campaigns f ...
DEC 02, 2021
Cannabis Sciences
Can Cannabis Help Manage Autistic Spectrum Disorder?
DEC 02, 2021
Can Cannabis Help Manage Autistic Spectrum Disorder?
Autistic Spectrum Disorder (ASD) is a developmental disorder characterized by persistent deficits in social interaction, ...
DEC 06, 2021
Microbiology
Sino Biological Launched Omicron Variant Research Reagents
DEC 06, 2021
Sino Biological Launched Omicron Variant Research Reagents
Sino Biological Newly Launched A Panel of Research Reagents for SARS-CoV-2 Omicron Variant (B.1.1.529) Beijing, China, D ...
DEC 12, 2021
Drug Discovery & Development
Cyagen: One-Stop Research Model & Gene Therapy Solutions
DEC 12, 2021
Cyagen: One-Stop Research Model & Gene Therapy Solutions
With gene therapy demonstrating an enormous potential to treat a wide range of diseases, Cyagen has added a range of gen ...
DEC 26, 2021
Cell & Molecular Biology
Symbiotes Spark the Production of Psychedelics in These Flowers
DEC 26, 2021
Symbiotes Spark the Production of Psychedelics in These Flowers
Morning glory is a name for about 1,000 flowers that are in the Convolvulaceae family, and many produce ergot alkaloids.
JAN 20, 2022
Drug Discovery & Development
Review Finds Improved Transparency Among Antidepressant Drug Trials
JAN 20, 2022
Review Finds Improved Transparency Among Antidepressant Drug Trials
Trials relating to newly developed antidepressant drugs are becoming more transparent. The corresponding study was publi ...
Loading Comments...