MAY 08, 2018 9:46 PM PDT

No More Hair Loss? Osteoporosis Drug Treats Baldness

WRITTEN BY: Nouran Amin

 

 

According to The University of Manchester's Centre for Dermatology Research, a recent developed drug can lessen the stress experienced by both men and women who suffer from hair loss. Results from this study were published in PLOS Biology from the laboratory of Prof Ralf Paus.

The results indicate that the drug originally developed for treating osteoporosis produced a dramatic positive effect on human hair follicles donated by patients undergoing hair transplantation surgery.

At the present day, they are currently only 2 drugs that are available for treating male-pattern balding (androgenetic alopecia), which can happen as early as in one's 20s. HairGuard talks about just the case here. This was a doctoral project investigated by Dr. Nathan Hawkshaw and colleagues which aimed to examine how drugs can be developed to promote human hair growth with the intention of finding novel, well-tolerated agents for the treatment of hair loss.

This molecular approach was the first to identify the mechanisms of an old immunosuppressive drug, Cyclosporine A (CsA). Interestingly, Cyclosporine A has been commonly used since the 1980s as a crucial drug that suppresses transplant rejection and autoimmune diseases. Unfortunately, it holds severe-side effects such as the continuous growth of unwanted hair.

The investigative team worked on a full gene expression analysis of isolated human scalp hair follicles treated with CsA. This revealed that CsA reduces the expression of SFRP1, which is a protein that inhibits the development and growth of many tissues, including hair follicles. This identifies a completely novel mechanism of action of the old and widely used immunosuppressant.

Additionally, the team also examined why CsA induces hair growth which was found to be from a molecular pathway that antagonizes the SFRP1 protein.

Dr. Hawkshaw explains; "The fact this new agent, which had never even been considered in a hair loss context, promotes human hair growth is exciting because of its translational potential: it could one day make a real difference to people who suffer from hair loss. This makes our research clinically very relevant, as many hair research studies only use cell culture."

"Clearly though, a clinical trial is required next to tell us whether this drug or similar compounds are both effective and safe in hair loss patients."

 

 

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
NOV 22, 2020
Cannabis Sciences
Synthetic Cannabinoids Linked to Increased Deaths in Older Patients with COPD
NOV 22, 2020
Synthetic Cannabinoids Linked to Increased Deaths in Older Patients with COPD
Researchers from St. Michael’s Hospital in Toronto have found that two synthetic cannabinoids available on prescri ...
NOV 18, 2020
Drug Discovery & Development
Hepatitis C Drugs May Be Involved Coronavirus Treatment
NOV 18, 2020
Hepatitis C Drugs May Be Involved Coronavirus Treatment
At the present moment, there are no inhibitors that target protease activity of the novel SARS-CoV-2. The main proteases ...
DEC 18, 2020
Drug Discovery & Development
Antibiotic Reduces Risk of Deafness
DEC 18, 2020
Antibiotic Reduces Risk of Deafness
Gentamicin is an antibiotic recently shown to reduce the risk of developing deafness according to a Stanford Medicine st ...
DEC 28, 2020
Cannabis Sciences
Does Cannabis Affect Stress in Men and Women Differently?
DEC 28, 2020
Does Cannabis Affect Stress in Men and Women Differently?
Researchers from Washington State University have found that cannabis may blunt the stress response differently in males ...
DEC 28, 2020
Drug Discovery & Development
Anti-Diarrhea Drug Kills Aggressive Brain Cancer Cells
DEC 28, 2020
Anti-Diarrhea Drug Kills Aggressive Brain Cancer Cells
Glioblastoma is a very aggressive and lethal form of brain cancer that responds poorly to chemotherapy in children and a ...
JAN 05, 2021
Drug Discovery & Development
Promising Epigenetic Treatment for Depression Works After One Dose
JAN 05, 2021
Promising Epigenetic Treatment for Depression Works After One Dose
Researchers affiliated with the University of Sao Paulo in Brazil have used epigenetic modulators to reduce stress-induc ...
Loading Comments...