JUL 11, 2018 02:13 AM PDT

'Acetazolamide' Used To Treat Altitude Sickness, Slows Down the Development of Glioblastoma

WRITTEN BY: Nouran Amin

 

 

Acetazolamide, which is sold under the trade name Diamox and used to treat altitude sickness, is considered inexpensive to manufacture and easy to administer.

"I take it myself, whenever I go to the Rocky Mountains," explains study director Bahktiar Yamini, MD, a professor of neurosurgery at the University of Chicago Medicine. Although acetazolamide has minimal side effects, users report "a metallic taste when drinking something carbonated."

Acetazolamide is a studied to be a carbonic anhydrase inhibitor drug that can restore another drug's ability to eradicate tumor cells.

More specifically, acetazolamide when added to a drug called temozolomide (TMZ), it was seen to slow down the progression of glioblastoma in mouse models.

Acetazolamide enables TMZ to damage the DNA present in tumor cells in order to inhibit its growth.

Researchers discovered that glioblastoma patients with increased levels of a protein called BCL-3 (B cell CLL/lymphoma 3) were unresponsive to the effects exerted by the chemotherapeutic drug, TMZ. In particular, BCL-3 protects cancer cells from TMZ damage by activating a protective enzyme known as carbonic anhydrase II.

"We tested this combination treatment strategy in several animal models," Yamini said. “It cured some of them. Others had a 30 to 40 percent increase in survival time.”

Furthermore, the researchers examined BCL-3 levels from earlier human studies and found that patients with lower levels of BCL-3 who were treated with TMZ had a higher survival rate than patients who had high levels of this biomarker.

"An important feature of predictors like BCL-3 is that they are informative," the authors note. "They can identify pathways to improve treatment response."

By studying those pathways, carbonic anhydrase inhibitors were identified, such as acetazolamide, as a way to decrease the resistance to temozolomide.

"Our data," they note, demonstrate that it is the "induction of CAII by TMZ that is important in modulating response to therapy."

Confirming the use of BCL-3 to predict which patients will benefit from the use of temozolomide will require validation through clinical trials.

Additionally, the authors believe that repurposing the use of acetazolamide along with temozolamide might be particularly effective for patients with tumors that have high BCL-3 expression.

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
MAY 30, 2018
Drug Discovery
MAY 30, 2018
Antibody Offers New Hope For Celiac Disease Patients
Celiac disease is genetically predisposed to hereditary disease and a serious autoimmune disorder that can damage the small intestine upon the ingestion of...
JUL 06, 2018
Cell & Molecular Biology
JUL 06, 2018
Small Molecules Found to Dial Down Autoimmunity
Scientists have now identified two combinations of small molecules that tamp down a protein called STING....
JUL 12, 2018
Infographics
JUL 12, 2018
3D Imaging Advantage
Learn about the advantages and the technology behind 3D cellular image acquisition and analysis with this infographic from Molecular Devices....
JUL 31, 2018
Drug Discovery
JUL 31, 2018
DNA For Drug Development?
Genetic data of individuals who were customers of DNA testing service for the purpose of understanding their ancestry and genetic history, such as the comp...
AUG 14, 2018
Drug Discovery
AUG 14, 2018
Anticancer Drugs Help Plants Fight Infection
Drugs used for cancer treatments may now help plants fight diseases. A study conducted at Washington State University (WSU), by two plant pathologists&mdas...
SEP 11, 2018
Drug Discovery
SEP 11, 2018
Stimuli-Responsive Nanoparticles as a Drug Delivery Method
Researchers at Washington State University (WSU), who were finding a way to fight an inflammatory response that causes organ failure better known as sepsis...
Loading Comments...