OCT 14, 2020 1:45 PM PDT

Sanobiotec Produces Reliable THCV

WRITTEN BY: Angela Dowden

Lithuania-based bio Sanobiotec has joined a band of biotech companies moving into the synthetic cannabinoid market, by announcing that it has produced pure and stable tetrahydrocannabivarin (THCV).

With state-approved production and supply of cannabis-derived pharmaceutical products increasing both in the US and around the world, there are signs that synthetic cannabinoids will have advantages for the pharma industry over cannabinoids extracted from marijuana.

Tetrahydrocannabivarin (THCV) is a structural analogue of THC, the primary psychoactive component of cannabis, but unlike THC it is only psychoactive at high doses and produces a more motivated, mentally alert feeling of euphoria.

The human endocannabinoid system includes two primary receptors—cannabinoid receptors 1 and 2 (CB1 and CB2). While THC functions by activating both, THCV functions are more nuanced.

“At low doses, THCV competes and displaces other molecules to inhibit CB1 and CB2, but at higher doses, the compound works to activate CB1. It is this unique mechanism that sets it apart in the cannabinoid repertoire,” Rytis V. Urbonas, CEO at Sanobiotec said.

Furthermore, “the compound … can differentially bind to GPR55 and TRPV1, [two more more minor cannabinoid receptors] as an antagonist or agonist depending on concentration, thus triggering complex metabolic pathways that are characteristically different from cannabinoid receptors, suggesting potential therapeutic effects that are not usually attributed to cannabinoids,” reports Urbonas.

THCV has demonstrated efficacy in pre-clinical studies as an anti-inflammatoryanti-psychotic and neuro-protectant. The compound was also successful in lowering plasma glucose and improving pancreatic cell function in a study of 62 subjects.

Moreover, THCV demonstrated high tolerance and safety in a randomized placebo-controlled trial.

Meanwhile the CDC warns that street versions of synthetic cannabinoids can be toxic and says that the Illinois Department of Public Health (IDPH) has received reports of multiple cases of sickness in people who have used contaminated synthetic cannabinoids. Symptoms can include bleeding, rapid heart rate, vomiting, agitation, confusion, and hallucinations.

 

Sources: Marijuana Business Daily, Nutraceutical Business Review

 

About the Author
  • I'm a journalist and author with many year's experience of writing for both a consumer and professional audience, mostly on nutrition, health and medical prescribing. My background is food science and I'm a registered nutritionist.
You May Also Like
MAR 09, 2021
Cannabis Sciences
Top Benefits of Having Your Medical Marijuana Card
MAR 09, 2021
Top Benefits of Having Your Medical Marijuana Card
With the use of medicinal marijuana booming, estimated at almost 4.5 million patients in 2020, it’s time to talk a ...
MAR 10, 2021
Microbiology
Gut Microbes Could be a Way to Treat Some Neurological Disorders
MAR 10, 2021
Gut Microbes Could be a Way to Treat Some Neurological Disorders
Researchers and clinicians have often studied genes that affect the function and development of the brain to explain neu ...
MAR 18, 2021
Immunology
COVID Cytokine Storm Chasers Look Inside the Lungs
MAR 18, 2021
COVID Cytokine Storm Chasers Look Inside the Lungs
Immunologists have revealed one of the underlying mechanisms behind COVID’s life-threatening cytokine storms. By s ...
MAR 24, 2021
Cancer
What toxic chemicals are lurking in your couch?
MAR 24, 2021
What toxic chemicals are lurking in your couch?
New research published in the journal Environment International suggests a weekend trip to the nearest furniture st ...
MAR 30, 2021
Drug Discovery & Development
Common Alzheimer's Drugs Reduce Mortality Rate and Cognitive Decline
MAR 30, 2021
Common Alzheimer's Drugs Reduce Mortality Rate and Cognitive Decline
Researchers from the Karolinska Institute and Umea University in Sweden have found that a commonly recommended group of ...
APR 09, 2021
Microbiology
A Neurological Disorder Sometimes Seen After Vaccinations
APR 09, 2021
A Neurological Disorder Sometimes Seen After Vaccinations
Functional neurological disorder (FND) is a real neuropsychiatric disorder that some people have after medical procedure ...
Loading Comments...