OCT 14, 2020 1:45 PM PDT

Sanobiotec Produces Reliable THCV

WRITTEN BY: Angela Dowden

Lithuania-based bio Sanobiotec has joined a band of biotech companies moving into the synthetic cannabinoid market, by announcing that it has produced pure and stable tetrahydrocannabivarin (THCV).

With state-approved production and supply of cannabis-derived pharmaceutical products increasing both in the US and around the world, there are signs that synthetic cannabinoids will have advantages for the pharma industry over cannabinoids extracted from marijuana.

Tetrahydrocannabivarin (THCV) is a structural analogue of THC, the primary psychoactive component of cannabis, but unlike THC it is only psychoactive at high doses and produces a more motivated, mentally alert feeling of euphoria.

The human endocannabinoid system includes two primary receptors—cannabinoid receptors 1 and 2 (CB1 and CB2). While THC functions by activating both, THCV functions are more nuanced.

“At low doses, THCV competes and displaces other molecules to inhibit CB1 and CB2, but at higher doses, the compound works to activate CB1. It is this unique mechanism that sets it apart in the cannabinoid repertoire,” Rytis V. Urbonas, CEO at Sanobiotec said.

Furthermore, “the compound … can differentially bind to GPR55 and TRPV1, [two more more minor cannabinoid receptors] as an antagonist or agonist depending on concentration, thus triggering complex metabolic pathways that are characteristically different from cannabinoid receptors, suggesting potential therapeutic effects that are not usually attributed to cannabinoids,” reports Urbonas.

THCV has demonstrated efficacy in pre-clinical studies as an anti-inflammatoryanti-psychotic and neuro-protectant. The compound was also successful in lowering plasma glucose and improving pancreatic cell function in a study of 62 subjects.

Moreover, THCV demonstrated high tolerance and safety in a randomized placebo-controlled trial.

Meanwhile the CDC warns that street versions of synthetic cannabinoids can be toxic and says that the Illinois Department of Public Health (IDPH) has received reports of multiple cases of sickness in people who have used contaminated synthetic cannabinoids. Symptoms can include bleeding, rapid heart rate, vomiting, agitation, confusion, and hallucinations.

 

Sources: Marijuana Business Daily, Nutraceutical Business Review

 

About the Author
  • I'm a Journalist and author with many year's experience of writing for both a consumer and professional audience, mostly on nutrition, health and medical prescribing. My background is food science and I'm a registered nutritionist.
You May Also Like
DEC 21, 2020
Cell & Molecular Biology
Mutagens May Be Having a Bigger Effect Than We Knew
DEC 21, 2020
Mutagens May Be Having a Bigger Effect Than We Knew
New research has suggested that our DNA is more susceptible to mutagenic influences than we've appreciated. While organi ...
DEC 23, 2020
Health & Medicine
Holiday Cheer: Americans Swap Alcohol for Cannabis this Christmas
DEC 23, 2020
Holiday Cheer: Americans Swap Alcohol for Cannabis this Christmas
Cannabis users polled by Glasshouse Group — a California-based cannabis and hemp company, which runs several dispe ...
DEC 23, 2020
Clinical & Molecular DX
Smartphone Device Uses CRISPR to Check for COVID
DEC 23, 2020
Smartphone Device Uses CRISPR to Check for COVID
Quick, portable, and ultrasensitive—a new smartphone test for COVID-19 checks all the boxes needed to get a handle ...
JAN 11, 2021
Cell & Molecular Biology
Ginger May Help Slow Lupus or Antiphospholipid Syndrome Progression
JAN 11, 2021
Ginger May Help Slow Lupus or Antiphospholipid Syndrome Progression
Naturally occurring chemicals make more appealing medicines for many people, but there is not always evidence that they' ...
JAN 17, 2021
Immunology
A Single Dose Nanoparticle Vaccine for COVID-19
JAN 17, 2021
A Single Dose Nanoparticle Vaccine for COVID-19
In the race for finding the right vaccine for the COVID-19 pandemic, a new vaccine candidate emerged. Researchers at Sta ...
JAN 24, 2021
Genetics & Genomics
Rare Neurodevelopment Disorder LINKED is IDed
JAN 24, 2021
Rare Neurodevelopment Disorder LINKED is IDed
Scientists have now characterized a genetic disorder called linkage-specific-deubiquitylation-deficiency-induced embryon ...
Loading Comments...