DEC 03, 2015 9:59 AM PST

Inflammatory Molecules Linked to Rare Bone Growth Disease

WRITTEN BY: Kara Marker
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disease that causes bone to grow in abnormal areas like ligaments, tendons, and skeletal muscles. This atypical growth causes soft tissues to "undergo a metamorphosis" transforming normally flexible tissues into hard bone, "locking joints in place and making movement impossible" (National Organization for Rare Disorders).

In the past, treatment for this debilitating disorder included targeting the signaling pathway of bone morphogenetic proteins (BMPs), since the hyperactivity of these multi-functional growth factors is the root cause of FOP (NIH). However, in a new study published in PNASscientists from the Center for iPS Cell Research and Application (CiRA) at Kyoto University utilized the ability of induced pluripotent stem cells (iPSCs) to reprogram diseased cells in FOP patients. 
FOP in a mouse model: abnormal bone growth is circled

iPSCs are listed by the NIH as "adult cells that have been genetically reprogrammed to an embryonic stem cell–like state," meaning they are essentially identical donor cells that can be induced to differentiate differently, making them useful by scientists to repair diseased tissues. 

People with the genetic mutation for FOP develop symptoms of the disease after experiencing inflammation or trauma. The team from CiRA aimed to utilize the reprogrammable iPSCs in FOP mouse models to identify a certain inflammatory molecule triggering FOP development and potentially reverse its effect.

Studying alternative treatments to BMP signaling drug targets introduces an entirely new perspective on FOP treatment. CiRA scientists believed that the abnormality of BMP signaling causing FOP could be either unconditional BMP activation or atypically enhanced signaling strength when BMP is activated. Looking closer at the cause of FOP BMP signaling, they identified the role of Activin-A, a member of the transforming growth factor-beta superfamily, in the onset of FOP (NIH). 

“Using iPS cell technology, the scientists found that only cells harboring the FOP gene mutation would respond to Activin-A by significantly increasing their BMP signaling," a report from Kyoto University stated. 

Since immune actions in response to trauma trigger FOP, the treatment and study of FOP has historically been very complicated, seeing as surgical treatments to remove excessive bone only stimulate more irregular bone growth. The discovery of Activin-A's connection to BMP signaling offers a new method for repressing diseased bone growth in FOP patients and lends new information to the realm of drug discovery and bone growth in general. 

Watch the following video to learn more about the clinical application potential of iPSCs.


Source: Kyoto University 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
DEC 15, 2020
Immunology
Yes, You Should Get Your Flu Vaccine.
DEC 15, 2020
Yes, You Should Get Your Flu Vaccine.
A recent study published in Science Translational Medicine has provided fresh insights on how our immune systems protect ...
DEC 13, 2020
Cardiology
Potential Treatment for Common Cause of Heart Disease is ID'ed
DEC 13, 2020
Potential Treatment for Common Cause of Heart Disease is ID'ed
The most common cause of heart disease in elderly people is calcific aortic valve disease, in which calcium builds up in ...
DEC 24, 2020
Cardiology
The Detrimental Health Impact of Ultra-Processed Foods
DEC 24, 2020
The Detrimental Health Impact of Ultra-Processed Foods
Prepared and highly processed foods have become very common, and they've been linked to negative health effects like obe ...
JAN 04, 2021
Microbiology
Some Microbes Could Help Treat Type 2 Diabetes
JAN 04, 2021
Some Microbes Could Help Treat Type 2 Diabetes
The microbial community in our gastrointestinal tract has been shown to have a significant impact on our health and well ...
JAN 13, 2021
Plants & Animals
San Diego Zoo's Gorillas Positive for COVID-19
JAN 13, 2021
San Diego Zoo's Gorillas Positive for COVID-19
Earlier this week, the Associated Press reported that several gorillas at the San Diego Zoo Safari Park tested positive ...
JAN 14, 2021
Health & Medicine
Cannabis Use May Affect Pregnancy Chances
JAN 14, 2021
Cannabis Use May Affect Pregnancy Chances
Some people find that pot can give their sex life a boost. But if you’re planning opt make a baby using cannabis m ...
Loading Comments...