DEC 03, 2015 9:59 AM PST

Inflammatory Molecules Linked to Rare Bone Growth Disease

WRITTEN BY: Kara Marker
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disease that causes bone to grow in abnormal areas like ligaments, tendons, and skeletal muscles. This atypical growth causes soft tissues to "undergo a metamorphosis" transforming normally flexible tissues into hard bone, "locking joints in place and making movement impossible" (National Organization for Rare Disorders).

In the past, treatment for this debilitating disorder included targeting the signaling pathway of bone morphogenetic proteins (BMPs), since the hyperactivity of these multi-functional growth factors is the root cause of FOP (NIH). However, in a new study published in PNASscientists from the Center for iPS Cell Research and Application (CiRA) at Kyoto University utilized the ability of induced pluripotent stem cells (iPSCs) to reprogram diseased cells in FOP patients. 
FOP in a mouse model: abnormal bone growth is circled

iPSCs are listed by the NIH as "adult cells that have been genetically reprogrammed to an embryonic stem cell–like state," meaning they are essentially identical donor cells that can be induced to differentiate differently, making them useful by scientists to repair diseased tissues. 

People with the genetic mutation for FOP develop symptoms of the disease after experiencing inflammation or trauma. The team from CiRA aimed to utilize the reprogrammable iPSCs in FOP mouse models to identify a certain inflammatory molecule triggering FOP development and potentially reverse its effect.

Studying alternative treatments to BMP signaling drug targets introduces an entirely new perspective on FOP treatment. CiRA scientists believed that the abnormality of BMP signaling causing FOP could be either unconditional BMP activation or atypically enhanced signaling strength when BMP is activated. Looking closer at the cause of FOP BMP signaling, they identified the role of Activin-A, a member of the transforming growth factor-beta superfamily, in the onset of FOP (NIH). 

“Using iPS cell technology, the scientists found that only cells harboring the FOP gene mutation would respond to Activin-A by significantly increasing their BMP signaling," a report from Kyoto University stated. 

Since immune actions in response to trauma trigger FOP, the treatment and study of FOP has historically been very complicated, seeing as surgical treatments to remove excessive bone only stimulate more irregular bone growth. The discovery of Activin-A's connection to BMP signaling offers a new method for repressing diseased bone growth in FOP patients and lends new information to the realm of drug discovery and bone growth in general. 

Watch the following video to learn more about the clinical application potential of iPSCs.


Source: Kyoto University 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAR 31, 2021
Clinical & Molecular DX
A Non-Invasive Look at Fat Distribution in the Liver
MAR 31, 2021
A Non-Invasive Look at Fat Distribution in the Liver
The build-up of fat inside the liver is a worrying sign that points to the possibility of conditions such as nonalcoholi ...
APR 08, 2021
Health & Medicine
Patented Mix of Terpenes and CBD Has Potential to Help COVID
APR 08, 2021
Patented Mix of Terpenes and CBD Has Potential to Help COVID
Israeli-based technology firm Eybna, who specialize in isolating and testing components from the cannabis plant, say tha ...
APR 09, 2021
Plants & Animals
Celebrating National Pet Day
APR 09, 2021
Celebrating National Pet Day
Sunday, April 11, is National Pet Day! From pandemic companions to viral videos, pets are a huge part of our lives. Even ...
APR 14, 2021
Clinical & Molecular DX
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
APR 14, 2021
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
A patient undergoes chemotherapy and radiation for rectal cancer. How do doctors know whether all the malignant tissue h ...
APR 13, 2021
Microbiology
Learning How TORCH Pathogens Cause Brain Malformations
APR 13, 2021
Learning How TORCH Pathogens Cause Brain Malformations
The term TORCH pathogens refers to a group of viruses including Toxoplasma gondii, Rubella, Herpes Simplex Viruses 1 and ...
APR 15, 2021
Drug Discovery & Development
Magic Mushroom Therapy and Antidepressants Produce Similar Results
APR 15, 2021
Magic Mushroom Therapy and Antidepressants Produce Similar Results
In recent years, psilocybin (the psychoactive ingredient in 'magic mushrooms') has gained increasing amounts of ...
Loading Comments...