JAN 09, 2018 7:36 AM PST

Why This One Amish Family Lives Longer and Healthier Than Most

Eat right. Get regular exercise. Don't smoke, don't use drugs and avoid stress. These pieces of advice are the mantras of most health professionals. If the goal is to live a long life, following these recommendations will definitely improve the odds.

Indeed, many of the trappings of "modern" life such as better nutrition, more accurate information on disease and better access to medical care are the reason some of us are living longer. Is it always the environment, however? A recent study at Northwestern University suggests that a rare genetic mutation found in a single family living in the Old Order Amish community near Berne, Indiana could be the cornerstone of developing an anti-aging drug that would increase longevity.

The study revealed that some of the Indiana Amish kindred (immediate family members and relatives) who have the mutation live longer, by about 10%, than those without it. Along with the mutation, this group of Amish also have longer telomeres. Telomeres are structures, which resemble an end cap on strands of DNA. They can be compared to the bits of plastic at the end of shoelaces (Trivia tip, those are called aglets) and when cells divide, which happens as we age, they get shorter and shorter. The genetic mutation that causes longer telomeres has a protective effect against aging because, with more material, cells stay healthier longer.

One of the benefits the study found was that Amish participants who have the mutation, also have a lower incidence of diabetes and lower levels of fasting insulin. These patients also have better vascular health, with increased flexibility in blood vessels and less arterial stiffening, which results in less heart disease.

Dr. Douglas Vaughan, the lead author of the study, explained another bonus the Amish with the mutation have, which is a lower level of a protein called PAI-1 (plasminogen activator inhibitor,) which is known to be involved in the aging process. Dr. Vaughn explained, "The findings astonished us because of the consistency of the anti-aging benefits across multiple body systems. For the first time we are seeing a molecular marker of aging (telomere length), a metabolic marker of aging (fasting insulin levels) and a cardiovascular marker of aging (blood pressure and blood vessel stiffness) all tracking in the same direction in that these individuals were generally protected from age-related changes. That played out in them having a longer lifespan. Not only do they live longer, they live healthier. It's a desirable form of longevity. It's their ‘health span.'"

The mutation is that only one copy of the relevant gene exists in some of the Amish. Those who have two copies do not have the same protective effect against diabetes. So what can be done with this information? Vaughn's team at Northwestern has partnered with scientists at Tohoku University in Japan and is testing an oral medication, TM5614, which tamps down the action of PAI-1. The drug has been tested in Japan on humans already, with Phase 1 trials complete and Phase 2 beginning soon. Northwestern will be starting trials of it, with study participants who have Type 2 diabetes and obesity, shortly. Check out the video below to see how this work could advance the science of aging.

Sources: Northwestern University, Journal article, Science Advances, New York Times

About the Author
  • I'm a writer living in the Boston area. My interests include cancer research, cardiology and neuroscience. I want to be part of using the Internet and social media to educate professionals and patients in a collaborative environment.
You May Also Like
OCT 01, 2020
Chemistry & Physics
Canadian Scientists Hope to Take Lead in Neutron Research, Again
OCT 01, 2020
Canadian Scientists Hope to Take Lead in Neutron Research, Again
(Pixabay/geralt) Neutron sources are the key to advancing research in many areas such as energy storage, mechanical engi ...
SEP 29, 2020
Chemistry & Physics
The benefits of electronic blood vessels
SEP 29, 2020
The benefits of electronic blood vessels
New research published in the journal Matter reports on the development of electronic blood vessels that are capable of ...
OCT 05, 2020
Health & Medicine
Cannabis Chemotherapy Trial Shows Encouraging Phase II Results
OCT 05, 2020
Cannabis Chemotherapy Trial Shows Encouraging Phase II Results
Even with the best anti-nausea medications one in three patients receiving chemotherapy experiences vomiting, and about ...
OCT 12, 2020
Cancer
Targeting Energy Production in Cells to Fight Leukemia
OCT 12, 2020
Targeting Energy Production in Cells to Fight Leukemia
Much like how a car needs gasoline to run, cells also need a fuel source. Most human cells in the body use oxidative pho ...
OCT 14, 2020
Cancer
Using Plasma Scalpels with Chemotherapy Against Brain Cancer
OCT 14, 2020
Using Plasma Scalpels with Chemotherapy Against Brain Cancer
Cold atmospheric plasma is a relatively new technique that utilizes a tool that generates a sort of plasma scalpel, exce ...
OCT 18, 2020
Microbiology
Mouth Microbes Play a Role in Oral Cancer Development
OCT 18, 2020
Mouth Microbes Play a Role in Oral Cancer Development
Oral hygiene is not only important for keeping teeth and gums healthy; it can also affect a person's health in general.
Loading Comments...