JUN 18, 2018 06:25 AM PDT

Detecting and Diagnosing Rheumatoid Arthritis Before it Begins

WRITTEN BY: Kara Marker

Unique gene signatures and tiny changes in the immune system that occur in the earliest stages of rheumatoid arthritis, an autoimmune disease, could soon be used to apply new diagnostic methods and provide early therapeutic intervention. From the European League Against Rheumatism (EULAR), scientists present their newest findings on how to identify which at-risk individuals will ultimately develop rheumatoid arthritis.

Rheumatoid arthritis: X-ray image of the hand with large changes in destructive arthritis.

People with rheumatoid arthritis (RA) are plagued with chronic inflammation in the joints, often the hands, feet, wrists, elbows, knees, and ankles. Inflammation in the joints causes the synovium to thicken, the joint tissue responsible for lubricating the joints and allowing easy movement. This thickening is what leads to the swelling and pain experienced by RA patients. Findings from this study could one day lead to early therapeutic interventions that could prevent irreversible damage to the joints and inhibit progression of the disease.

When specific autoantibodies are discovered, a person is known to be an increased risk of developing RA, although the presence of these autoantibodies does not necessarily seal their fate. Autoantibodies are produced in many different autoimmune diseases. They represent a malfunction in the immune system, where B cells produce antibodies that target the body’s own cells and tissues instead of producing antibodies that target foreign invaders like bacteria and viruses.

"These studies may help us better understand and potentially identify which individuals classified as at-risk will go on to develop RA," explained EULAR’s Robert Landewé. "This is important because it will contribute to the development of early preventative strategies including potential pharmacological treatment to prevent the onset of disease."

Researchers began their study with 67 synovial tissue samples from the knee joint of individuals with an early risk of RA. With just 13 participants, they conducted a genome-wide transcriptional profile study aimed at identifying unique gene signatures associated with RA development. They found 3,151 gene signatures linked to elevated risk of RA and 2,437 signatures linked with a lower risk. They confirmed these results using a technique called quantitative real-time PCR.

"Our results clearly show molecular changes appearing in the synovial tissue before the onset of arthritis," said Dr. Lisa van Baarsen. "The characterization of these gene signatures will enable us to better understand the pathophysiology of the pre-clinical phase of the disease and potentially identify novel drug targets for preventive intervention."

In addition to classifying genetic risk biomarkers, researchers also observed changes in immune-regulated pathways involving T cells and B cells, cytokines and chemokines, and antigen processing and presentation.

"Our data support a new biomarker that demonstrates better predictive power compared with other available biomarkers evaluated so far," said Ms. Anne Musters, MD.

The findings from this study were recently presented at the Annual European Congress of Rheumatology.

Sources: Arthritis Foundation, European League Against Rheumatism (EULAR)

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
SEP 21, 2018
Immunology
SEP 21, 2018
Intrauterine Protection from Allergy Season
Pregnancies during allergy season may provide protection against allergy development in children...
OCT 16, 2018
Drug Discovery
OCT 16, 2018
Immunotherapeutic Targets A Blood-Clotting Protein
Fibrin is a blood protein that normally does not cross to the brain, however, several neurological disorders have a defect in the blood-brain barrier that ...
NOV 07, 2018
Immunology
NOV 07, 2018
Inflammation Can Steal Your Sleep
A link between inflammation and the circadian rhythm has been determined in mouse models. High-fat-diets may be the cause....
DEC 12, 2018
Immunology
DEC 12, 2018
The Structure of Immunity
A group of researchers describes the biophysical and structural characteristics of an immune regulating protein called human T cell immunoglobulin and mucin domain-containing protein-3 (hTIM-...
DEC 26, 2018
Immunology
DEC 26, 2018
When the Immune System Makes a Mistake: Autoimmunity
A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune system attacks the body's healthy cells....
JAN 15, 2019
Immunology
JAN 15, 2019
A Possible Key to Severe Flu
By studying the impact that NPY and its receptor Y1R have on influenza in mice, the research group has now discovered that NPY produced in lung phagocytes can aggravate influenza....
Loading Comments...