MAY 24, 2019 9:28 AM PDT

Studies Confirm That a Poor Diet can Lead to Disease

WRITTEN BY: Carmen Leitch

Recent work reported in the Lancet has shown that people all over the world can improve their health by eating a more balanced diet. The study assessed fifteen dietary factors over 27 years in 195 countries. It found that around 11 million deaths, about one in five, are linked to a poor diet, characterized by low levels of nuts, whole grains, fruits, and seeds and high amounts of sugar, red and processed meat, and trans fats. The authors stress that there is a critical need to improve diets worldwide.

Image credit: Max Pixel

"This study affirms what many have thought for several years - that poor diet is responsible for more deaths than any other risk factor in the world," said an author of the Lancet study Dr. Christopher Murray, Director of the Institute for Health Metrics and Evaluation at the University of Washington. "While sodium, sugar, and fat have been the focus of policy debates over the past two decades, our assessment suggests the leading dietary risk factors are high intake of sodium, or low intake of healthy foods, such as whole grains, fruit, nuts and seeds, and vegetables." The authors noted that healthy food consumption should be promoted everywhere.

Of the 195 countries included in the report, Uzbekistan had the highest proportion of diet-related deaths, while Israel was lowest. The rankings put the UK at 23rd (127 deaths per 100,000), the US at 43rd (171 deaths per 100,000), and China at 140th (350 deaths per 100,000 people). China, Japan, and Thailand are burdened by high sodium levels, while a lack of whole grains is the leading dietary problem leading to disease or death in the US and several other countries.

Murray discusses the US Burden of Disease study in the video.

There is some good news, however. The right diet can have a good impact on the community of microbes living in our gastrointestinal tract; the gut microbiome has a powerful effect on our health and well-being. A balanced diet in combination with a healthy group of gut microbes can help prevent disease too. Foods that are high in fibers can help lower the risk of developing some diseases like colorectal cancer. The association between a high-fiber diet and a lower risk of cancer is known, but the mechanisms underlying that relationship aren’t well-understood.

Now researchers at the University of Luxembourg have learned more. An in vitro model of the gut called HuMiX, a so-called gut-on-a-chip, allowed the scientists to study how certain strains of bacteria interacted with human intestinal cells. They found that a combination of dietary fibers and beneficial bacteria (and not either on its own) reduced the expression of genes that are linked to cancer and drug-resistance. Further study identified the molecules that the combination treatment generated that had a healthy impact. This research was published in Cell Reports.

"Currently, cancer patients are not provided with evidence-based personalized dietary interventions during chemotherapy treatment. Our results provide support for exploiting the food-microbiome interactions as a supportive therapeutic approach in anti-cancer therapy," explained the lead author of the Cell Reports study, Dr. Kacy Greenhalgh. "I hope that our results will reach patients and medical practitioners in their respective fields and that in the future more effort is put in including personalized dietary recommendations into cancer treatment plans."

The video above discusses another recent study reported in JNCI Cancer Spectrum, which linked five percent of cancer deaths to a poor diet.

Sources: AAAS/EurekalertUniversity of Luxembourg, The Lancet, Cell Reports

About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
MAR 23, 2021
Genetics & Genomics
Implementing Illumina NGS is a lot easier than you think.
MAR 23, 2021
Implementing Illumina NGS is a lot easier than you think.
Dr. John-Sebastian Eden is a Virologist at the Westmead Institute for Medical Research in Sydney, Australia. His group u ...
APR 15, 2021
Clinical & Molecular DX
A Portable Ebola Detector, 1000x More Sensitive Than Lab-Based Tests
APR 15, 2021
A Portable Ebola Detector, 1000x More Sensitive Than Lab-Based Tests
Duke University scientists have created a highly sensitive Ebola virus portable diagnostic device, 1000 times more sensi ...
APR 16, 2021
Microbiology
A New Kind of COVID-19 Vaccine
APR 16, 2021
A New Kind of COVID-19 Vaccine
The current COVID-19 vaccines by Pfizer/BioNTech and Modern are based on messenger RNA, which cells use to make proteins ...
APR 29, 2021
Microbiology
Cell Atlas Helps Explain the Deadly Nature of SARS-CoV-2
APR 29, 2021
Cell Atlas Helps Explain the Deadly Nature of SARS-CoV-2
For over a year now, scientists and clinicians have been trying to understand why the SARS-CoV-2 virus causes such deadl ...
APR 29, 2021
Immunology
A Week for World Immunization
APR 29, 2021
A Week for World Immunization
The World Health Organization (WHO) is calling our attention to World Immunization Week, which comes in the last week of ...
MAY 02, 2021
Cell & Molecular Biology
Coral Cells Can Spit Out the Symbionts They Don't Want
MAY 02, 2021
Coral Cells Can Spit Out the Symbionts They Don't Want
Some microalgae are symbionts, like dinoflagellates that live in coral. A symbiotic sea anemone is seen in this image by ...
Loading Comments...