JAN 04, 2019 3:51 PM PST

When the ADAR1 Enzyme Goes Awry, it Encourages Cancer

WRITTEN BY: Carmen Leitch

Scientists at the University of California San Diego School of Medicine have identified a function of an enzyme called ADAR1 (adenosine deaminase acting on RNA 1). It’s a member of a small family of enzymes that help control gene expression by altering bases of double-stranded RNA molecules. The work shows that ADAR1 might be a new target when developing ways stop cancer cells from gaining resistance to therapeutics, and may help show at an early stage when cells are becoming malignant.
  
In pre-malignant cells, the enzyme’s functions are taken over, and it’s used to promote the transformation of a cell to malignancy. “We were able to illuminate the abilities of ADAR1 to ‘hyper-mutate’ tumor suppressor RNAs in leukemia and, at the same time, edit the microRNA aimed at targeting the tumor suppressor RNA. This enzyme turns on cancer resistance via a domino effect on RNA instead of DNA,” explained Qingfei Jiang, Ph.D., the first author of a report on the findings in Cancer Cell.

 

Sources: UCSD News, Cancer Cell

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
MAR 15, 2020
Plants & Animals
MAR 15, 2020
The Incredible Life of a Sea Urchin
From start to finish, a sea urchin’s life involves an incredible and lengthy journey. From the moment a wandering ...
MAR 22, 2020
Space & Astronomy
MAR 22, 2020
SpaceX to Send Astronauts to the ISS for the First Time in May
NASA’s Commercial Crew Program opened the door to the possibility that American commercial space companies like Bo ...
APR 08, 2020
Health & Medicine
APR 08, 2020
Researchers Examine Differences Between Hot & Cold Brewed Coffee
A cup of coffee is not a simple beverage these days. With a multitude of methods available, the cold brewing method has ...
APR 11, 2020
Clinical & Molecular DX
APR 11, 2020
Predecessors Of Periodontitis
Gingivitis is a mild periodontal disease that causes inflammation, irritation, redness, and swelling of the gingiva. Thi ...
MAY 01, 2020
Chemistry & Physics
MAY 01, 2020
John Conway: the Late Maths Legend and His Game of Life
If maths is the only universal language, then John Horton Conway is among the few who can speak it perfectly. Unfortunat ...
MAY 03, 2020
Space & Astronomy
MAY 03, 2020
How the Hubble Space Telescope Transformed Astronomy
The Hubble Space Telescope has officially spent three decades in outer space, making it one of the most renowned space o ...
Loading Comments...