Agnieszka is currently a Staff Scientist and Laboratory Manager at TessArae, LLC in Sterling, VA, USA. She obtained her PhD at the University of Queensland in Australia in a field of biochemistry, and subsequently worked as a post-doctoral fellow at Queen's University of Belfast ... University of Queensland and Institute for Molecular Biosciences. Since 2005 until 2008 she held a continuing appointment as a lecturer in a School of Dentistry at the University of Queensland and established her own laboratory in area of functional genomics and metabonomics. She has over 10 years of experience in molecular biology, genetics, genomics, biochemistry, microbiology and metabonomics. In addition she has experience as a science writer. Recently Agnieszka served on the Council of the Australian Society for Biochemistry and Molecular Biology and is still active in the society. Currently she is working on novel diagnostic assays for infectious diseases using microarray re-sequencing technology.

Emily Hollister is the Director, R&D, Computational Biology for Diversigen. An accomplished microbial ecologist, her microbiome experience ranges from soils and biofuel production systems to the human microbiome and pre-clinical disease models. She leads a team of ... bioinformaticians and data scientists, dedicated to developing novel analytical solutions to support microbiome services and product development in the OraSure family of companies. Emily holds a Ph.D. in Molecular and Environmental Plant Sciences from Texas A&M University. She completed her postdoctoral training in Molecular Microbial Ecology at Texas A&M University and has served on the faculty at Baylor College of Medicine and the Texas Children's Microbiome Center.

Eugean Jiwanmall's past professional experiences include basic science and clinical research. In his current role as a Senior Research Analyst for Medical Policy & Technology Evaluation at Independence Blue Cross' Claim Payment Policy Department within Facilitated Health ... Networks, he has served as the subject-matter-expert, writer, reviewer, communicator, presenter, consultant, & decision-maker for hundreds of medical policy topics & technology assessments within dozens of clinical disciplines & multiple business areas. Eugean is finishing graduate work in bioethics at the University of Pennsylvania School of Medicine. He holds a bachelor's degree in biological sciences with honors from Drexel University (minor was in business administration), a master's degree of public health in evaluative clinical sciences from Dartmouth Medical School, and an MBA in health care management and economics with honors from Drexel University.

Jonas Korlach was appointed Chief Scientific Officer of Pacific Biosciences in July 2012. He was previously a Scientific Fellow, supporting commercial development of the PacBio RS II system and performing research aimed at developing new applications for SMRT technologies. He ... co-invented the SMRT technology with Stephen Turner, Ph.D., Pacific Biosciences Founder and Chief Technology Officer, when the two were graduate students at Cornell University. Dr. Korlach joined Pacific Biosciences as the company's eighth employee in 2004. Previously, he was a Postdoctoral Researcher at Cornell University. Dr. Korlach is the recipient of multiple grants, an inventor on 70 issued U.S. patents and 61 international patents, and an author of over 70 scientific studies on the principles and applications of SMRT technology, including publications in Nature, Science, and PNAS. In 2013, Dr. Korlach was honored by the Obama White House as an Immigrant Innovator "Champion of Change." He received both his Ph.D. and his M.S. degrees in Biochemistry, Molecular and Cell Biology from Cornell, and received M.S. and B.A. degrees in Biological Sciences from Humboldt University in Berlin, Germany.

Degree: Ph.D. in Biochemistry, Institute of Bioorganic Chemistry, Polish Academy of Science, Poznań, Poland. Postdoc fellow in Human Genome Sequencing Center, Baylor College of Medicine... Interests: I'm interested in studying genomic variants and their effect, including the ... development of tools for comprehensive variant analysis (SNVs, SVs, and Methylation).

Tatjana is an immunologist with more than two decades of experience working at biotech and pharma companies from start-ups to large global corporations ( Pfizer,Inc. being the latest), contributing significantly to team efforts and successes of more than thirty early and clinical ... stage programs and several commercial products and biosimilars.

Molly McGinniss, MS, CGC, is Senior Director of Client and Partner Relations for Population Genomics at Genome Medical, a digital health company and specialty medical group focused on genetics and genomics. Through the Genome Medical Precision Insights team, she provides ... strategic consulting and support services to health care partners developing precision medicine and population genomics programs. She is a board-certified genetic counselor with extensive clinical and commercial experience. Molly began her career as a clinical genetic counselor providing prenatal, pediatric, and adult genetic counseling services. Prior to joining Genome Medical, she led global market development at Illumina for the genetic disease testing clinical segment. Molly received her B.S. in Biology from Loyola Marymount University in Los Angeles, and her M.S. in Genetic Counseling from Boston University. She currently serves as the President of the Accreditation Council for Genetic Counseling (ACGC), having served on the Board of Directors since 2018.

Dorottya earned her MD and PhD in clinical medicine from Semmelweis University of Medicine in Hungary. Holding postdoctoral fellowships at Baylor College of Medicine/Texas Children's Hospital and Columbia University, she has 10+ years of experience in translational medicine ... pediatrics, gastroenterology, microbiology, and clinical metagenomics. She led cutting-edge clinical trials on fecal microbiome transplantation and developed a multicenter research program to understand the role of the gut-brain axis in the integrative neuroscience field. Currently, Dorottya is the Chief Medical Officer at Biotia, a NYC-based startup focusing on rapid infectious disease diagnostics, surveillance, and prevention of hospital-acquired infections powered by artificial intelligence.

John Quackenbush is Professor of Computational Biology and Bioinformatics and Chair of the Department of Biostatistics at the Harvard TH Chan School of Public Health and Professor at the Dana-Farber Cancer Institute. John's PhD was in Theoretical Physics but a fellowship to work ... on the Human Genome Project led him through the Salk Institute, Stanford University, and The Institute for Genomic Research (TIGR), before joining Harvard in 2005. John's research uses massive data to probe how many small effects combine to influence our health and risk of disease. His published work has more than 87,000 citations and among his honors is recognition in 2013 as a White House Open Science Champion of Change. In 2012 he founded Genospace, a precision medicine software company that was sold to Hospital Corporation of America in 2017.

Dr. Fritz Sedlazeck completed his PhD in 2012 in the group of Dr. Arndt von Haeseler at the Max F. Perutz Laboratory in Vienna. After a two year postdoc, he transitioned to the lab of Dr. Michael Schatz at Cold Spring Harbor Laboratory and later to Johns Hopkins University. Since ... 2017 he leads his own group at the Human Genome Sequencing Centre at Baylor College of Medicine. His research focuses on developing computational methods to detect and analyse genomic variations with a focus on Structural Variations. Structural Variations are genomic events that manipulate multiple positions in a genome, which impact evolution, genomic disorders, regulation as well as play an important role in explaining multiple phenotypes.

Rachel Shelmerdine has over 12 years' experience in the diagnostics industry, with lead roles across R&D, product development and innovation/medical affairs at Qiagen and Yourgene Health. Rachel has a proven track record of taking innovative, proof of principle technologies ... through regulated Product Development processes, resulting in successful launch of clinical IVD genetic products in reproductive healthcare, oncology and infectious disease. Rachel holds a PhD in Molecular Immunology from the University of Sheffield, MSc in Statistics from Lancaster University, an undergraduate degree in Medical Biochemistry with the University of Manchester and, more recently, an Executive MBA from Lancaster University and is well-connected within the diagnostics area.

Dr. Tao Wu received his B.S. from Nankai University a leading academic institution in China. In his last year at college, his reading of "What Is Life? The Physical Aspect of the Living Cell" (by physicist Erwin Schrödinger, 1944) inspired him to pursue a career in deciphering ... the physical principles of biological systems. In 2003, Tao joined the Institute of Biophysics, Chinese Academy of Sciences (Beijing), where he was mentored by Prof. Runsheng Chen a founding father of genomics and bioinformatics research in China. Under his tutelage, Tao started to investigate the function and mechanisms of genome "Dark Matter" (i.e., non-coding RNAs) in C. elegans and human cancer models. During this training, Tao developed expertise in bioinformatics, genomics, and systems biology. He built one of the first non-coding-RNA-protein interaction databases (NPInter) [1] and subsequently developed a linear time-ordered computational model which was used to estimate the cell states during differentiation, reprogramming, or tumorigenesis [2-4]. To pinpoint the regulatory mechanism of non-coding RNAs during development in C. elegans, Tao led a project to systematically characterize the elements of non-coding RNAs transcriptional regulation with the DNaseI-Hypersensitive-Sites method in 2008, presaging the larger efforts as part of the modENCODE projects [5]. In the last year at graduate school, Tao began to tackle the question of how do cells commit to different cell fates with the same genomic DNA information? In 2010, Tao joined the newly established lab of Dr. Andrew Xiao at Yale to study epigenetics as a potential answer to this question. There, Tao utilized biochemistry and epigenetics approaches to complement his genomics expertise to tackle this problem. He applied these approaches to address the fundamental questions in the context of stem cell and Induced Pluripotent Stem Cell (iPSC) reprogramming. Identifying better biomarkers for assessing iPSC quality is an important goal for moving to clinical application. Instead of using transcriptional profiling or well-known histone modification markers, Tao discovered that an "epigenomic pattern mutation" of histone variants is essential for explaining the developmental variability of iPSCs. Tao discovered H2A.X, a histone variant of H2A that is usually involved in the DNA damage repair could mediate repression of extraembryonic lineage gene expression in embryonic stem cells (ESCs). He found that genomic deposition defects (called "epigenomic pattern mutation") frequently occur in the low-quality iPSC lines, whereas its deposition recapitulates the ESC's pattern in the high-quality iPSCs. The epigenomic pattern mutation of H2A.X leads to aberrant expression of extraembryonic lineage genes in low-quality iPSCs (which mimics the phenotype of H2A.X-knockout ESCs) and predisposes them to extraembryonic lineage differentiation in vitro and in vivo [6-8]. This work may pave the way for improved clinical application of iPSCs in regenerative medicine. Following up on this discovery, Tao continued to dissect the mechanism of how H2A.X is targeted to specific genomic loci. To identify the unique property of DNA at H2A.X-nucleosome deposition sites, he developed a novel variation of ChIP-Seq, "SMRT-ChIP", which can simultaneously determine DNA modifications and genomic sequences of histone binding sites. This approach leverages native Chromatin Immunoprecipitation (N-ChIP) and the 3rd generation single-molecule real-time sequencing (SMRT) technology. By in depth analysis of H2A.X SMRT-ChIP data, he enjoyed a true "Eureka Moment". Tao discovered a novel mammalian DNA modification, DNA N6-methyladenine (N6-mdA). This is a form of DNA methylation that had not yet been detected in mammals [9, 10]. Tao also showed that ALKBH1 is major demethylase of N6-mdA, and the main function of N6-mdA is targeting and silencing evolutionarily younger LINE-1 retrotransposons in ESCs [9]. The Identification of novel DNA modifications in mammalian genomes is a "holy-grail" question in the epigenetics field. Despite the extensive search by leading labs for over forty years, only 5-methylcytosine (5mC) and its derivatives were known as functional DNA modifications in mammals before 2016. Hence, Tao's work opened a new chapter in mammalian epigenetics and stem cell biology [10]. Importantly, Tao was quickly appreciated the potential link between this DNA rare modification and malignant tumors. Thus, Tao initiated collaborations with leading cancer biology labs to show that while N6-mdA is rare in normal somatic cells, it is greatly enriched in high-grade glioblastoma patients' samples. He hypothesized that N6-mdA may be a mechanism by which cancer stem cells hijacks an early embryological mechanism for adapting to cancer niches and therapeutic resistance.