MAY 18, 2017 8:00 AM PDT

WEBINAR: Create Your Own Cellular Compound-Target Engagement Assay

Sponsored by: DiscoverX
Speaker
  • Sr. Product Manager, DiscoverX Corporation
    Biography
      Dana Haley-Vicente, Ph.D., is currently a Sr. Product Manager at DiscoverX (Fremont, CA) managing cell-based assays, kits, and consumable products for drug discovery target discovery, screening, lead optimization, and SAR campaigns. She has been working in the life science drug discovery industry for over 16 years and received her Ph.D. in Pharmacology from University of California, Los Angeles.

    Abstract

    DATE: May 18, 2017
    TIME: 8:00AM PDT, 11:00AM ET

    It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad application of this cellular target engagement concept to drug discovery has been hindered by a lack of simple platforms with sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable methods for particular applications, but they can require target-specific antibodies for immuno-assay readouts, can be low-throughput for Western blot formats, and can be biased against multi-domain proteins. 
    Here we will describe InCELL Pulse™, which uses DiscoverX's Enzyme Fragment Complementation (EFC) technology to overcome these limitations of current thermal stabilization assays. This unique platform allows you to rapidly measure quantitative cellular target engagement potency values for inhibitors of diverse protein classes, including kinases, methyltransferases, and hydrolases. The tools and workflow for designing your own InCELL Pulse assays for your favorite target will be described and validation data will be highlighted.

    Learning Objectives:

    • Overview of compound-target engagement
    • Tools and workflow to create your own cell-based target engagement assay
    • Applications of InCELL Pulse assays

    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    MAY 18, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    MAY 18, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 18, 2021 Time: 7:00am PDT, 10:00am EDT Proteins encoded by mutant genes in cancers can be processed and presented on tumor cell surface by human leukocyte antigen (HLA) molecules,...
    MAY 18, 2017 8:00 AM PDT

    WEBINAR: Create Your Own Cellular Compound-Target Engagement Assay

    Sponsored by: DiscoverX

    Specialty

    Cancer Research

    Cell Biology

    Biotechnology

    Cancer Therapeutics

    Molecular Biology

    Drug Discovery

    Immunology

    Genetics

    Oncology

    Biochemistry

    Assay Development

    Cell Culture

    Biomarkers

    Gene Therapy

    Clinical Diagnostics

    Geography

    North America58%

    Europe20%

    Asia12%

    South America6%

    Oceania2%

    Africa2%

    Registration Source

    Website Visitors100%

    Job Title

    Scientist16%

    Student16%

    Executive13%

    Facility/Department Manager11%

    Research Scientist8%

    Educator/Faculty8%

    Medical Laboratory Technician8%

    Post Doc4%

    Lab Management4%

    Medical Doctor/Specialist3%

    Chemist2%

    Clinical Laboratory Scientist2%

    Marketing/Sales1%

    Biologist1%

    QC/QA1%

    Organization

    Biotech Company11%

    Academic Institution9%

    Pharmaceutical Company7%

    Research Institute7%

    Clinical Laboratory6%

    Medical School5%

    Life Science Company3%

    Medical Center3%

    Hospital3%

    Ambulatory Care2%

    Industrial Company2%

    Non-Profit Organization2%

    Media2%

    Contract Research Organization (Cro)2%

    Other6%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more