MAR 14, 2018 9:00 AM PDT

3D Dilemma of This Century

Presented at: Neuroscience 2018
Speaker
  • Professor of Psychiatry and Behavioral Sciences, Obstetrics and Gynecology, Director, Center for Neuroscience in Women's Health, Stanford University School of Medicine
    Biography
      Dr. Rasgon is a Professor in the departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology at Stanford University's School of Medicine. She began her distinguished career at Odessa Medical Institute and UCLA School of Medicine, and in 2002, she established the Center for Neuroscience in Women's Health at Stanford University. Dr. Rasgon is considered a renowned expert in neuroendocrinology and women's mental health. Dr. Rasgon is the author of more than 160 peer-reviewed publications, 25 book chapters, and is a reviewer for 30 professional journals. Her predominant research focus has been on neuroendocrine correlates in various models of affective and cognitive neuroscience, the treatment of bipolar disorder in women, the use of hormonal interventions during menopause and the effects on mood and cognitive function, and the interplay between endocrine function and aging.

    Abstract

    Most neuropsychiatric diseases involve multifactorial systems characterized by complex interactions among genetic predisposition/resiliency, environmental/social determinants, molecular sequelae and brain network organization. The allostatic load affects remodeling of brain architecture and physiological processes in response to stressors. The epigenetic allostasis emphasizes the influence of early-life experiences on the development of neuropsychiatric pathology in susceptible individuals. This presentation will cover the neurobiological frameworks underlying three main components of allostatic load – oxidative stress, inflammation and insulin resistance (IR) while accounting for genetic (familial) and epigenetic (early-life trauma) in human models. 


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