OCT 11, 2018 09:00 AM PDT

Association of Biotin Ingestion with Performance of Hormone and Nonhormone Assays in Healthy Adults

SPONSORED BY: DiaSorin
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Director of Clinical Chemistry, University of Minnesota Medical Center, and Assistant Professor of Laboratory Medicine and Pathology, University of Minnesota
    Biography
      Danni Li, PhD, DABCC, is the Director of Clinical Chemistry at the University of Minnesota Medical Center, Fairview and an Assistant Professor of Laboratory Medicine and Pathology at the University of Minnesota, Twin Cities. Dr. Li earned a BS in Chemistry from Zhejiang University in Hangzhou, China in 2002 and a PhD in Analytical Chemistry at the University of Minnesota in 2007. She completed the Clinical Chemistry Fellowship training at the Johns Hopkins University in 2009 and joined the faculty at the Johns Hopkins University in 2010. From January 2010 to August 2012, she was the Director of General Chemistry Laboratories at the Johns Hopkins Hospital and Assistant Professor of Pathology at the Johns Hopkins University. She is a member of American Association for Clinical Chemistry (AACC), and a Diplomat of American Board of Clinical Chemistry (DABCC). Dr. Li has authored over 30 peer-reviewed research articles, peer-reviewed review articles, editorial, case reports, and book chapters. In 2009, Dr. Li published a first case study from the United State on biotin interference with lab tests (i.e., PTH). She was also the first-author on a paper published in the Journal of American Medical Association (JAMA) on systematic evaluation of biotin interference on lab tests using a nonrandomized crossover trial of 6 healthy adults for 11 analytes on 37 assays over 4 major diagnostic systems. She has active research interests in high dose biotin supplement use prevalence in the United States and its impact on public health. In addition, Dr. Li has developed her independent research program in applying proteomics and lipidomics to discover plasma biomarkers in Alzheimer's disease.

    Abstract:

    High dose of biotin may cause interference with many routine clinical immunoassays and inaccurate results of some of the tests such as cardiac troponin has serious clinical complications. There is an increasing trend of high dose biotin supplement use in the US population, although the exact prevalence is still unknown. High dose of biotin supplement use may continue to increase due to its health and medical benefits and disrupt the diagnostic industry so some of the tests with serious clinical complications should be resigned to avoid biotin interference. Last but not least, more research is needed to understand the nutritional and therapeutic values of biotin.

    Learning Objectives:

    • Review mechanisms and factors that determine high dose biotin interference with lab tests
    • Describe an increasing trend of high dose biotin use and health and medical benefits
    • Explain why the continuing trend of high dose biotin use may be a game changer of the clinical diagnostic industry
    • Make a case for why more research is needed to understand nutritional and therapeutic values of biotin

    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    JUL 31, 2019 09:00 AM PDT
    C.E. CREDITS
    JUL 31, 2019 09:00 AM PDT
    DATE: July 31, 2019TIME: 9:00am PT, 12:00pm ET The choroid plexus, which makes up the blood-cerebrospinal fluid barrier in the central nervous system (CNS), lines the ventricle...
    AUG 15, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 15, 2019 09:00 AM PDT
    DATE: August 15, 2019TIME: 9:00am PDT, 12:00pm EDT Radiation therapy is a critical tool for the treatment of brain tumors, however, exposure to high doses of ionizing radiation...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    Loading Comments...
    Show Resources