MAR 29, 2018 1:30 PM PDT

Cannabidiol Treatment of Epilepsy and Autism Through Restoration of GABAergic Signaling

Speaker

Abstract

Cannabidiol (CBD) has emerged as a promising anti-epileptic drug in otherwise treatment-resistant genetic epileptic disorders. However, the clinical trials have been limited by their use of CBD only as an add-on therapy, their lack of assessment of CBD on comorbid phenotypes, and their lack of insight into CBD’s therapeutic mechanism. To address these limitations, we tested CBD’s effects on behavior and physiology in our genetic mouse model of Dravet Syndrome (DS). DS is a severe childhood epileptic disorder characterized by treatment resistant epilepsy, as well as cognitive and social deficits consistent with autism. Our DS mice recapitulate these core behavioral phenotypes and are thus a powerful precision medicine tool to test the efficacy of CBD as a monotherapy in DS. We find that acute CBD administration reduced the thermally-induced seizures that model febrile seizures in the early stage of DS. Twice-daily CBD administration also reduced the frequency of spontaneous seizures that characterize the later stages of DS.

These anti-epileptic effects were associated with an enhancement in GABAergic signaling in the dentate gyrus of the hippocampus, which is mediated by CBD antagonism of GPR55 signaling. Furthermore, we find that CBD rescued social interaction deficits and abnormal social responses in our DS mice. Together, our data suggest that CBD is an effective monotherapy against epileptic seizures and autism in DS. Our results also reveal that GPR55 signaling is an important target for CBD’s therapeutic benefits.

Learning Objectives:

  •  Be able to describe cannabidiol's benefits as a monotherapy in treating epilepsy and autism
  •  Understand the cellular mechanism by which cannabidiol rescues brain function that's disrupted   by genetic mutations
     

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
MAR 16, 2021 10:00 AM PDT
C.E. CREDITS
MAR 16, 2021 10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
JUL 15, 2021 9:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
JUL 15, 2021 9:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
MAR 25, 2021 8:00 AM PDT
C.E. CREDITS
MAR 25, 2021 8:00 AM PDT
Date: March 25, 2021 Time: 8:00am (PST), 11:00am (EST) Flow cytometry has expanded to have more users, more data, and multiple instrument types. While this has lead to more quantitative data...
MAR 29, 2018 1:30 PM PDT

Cannabidiol Treatment of Epilepsy and Autism Through Restoration of GABAergic Signaling


Specialty

Molecular Biology

Science

Laboratory Testing

Brain

Research And Development

Publishing

Health

Cell Biology

Neuroscience

Gene

Life Science

Animal Behavior

Clinical Oncology

Genetic Engineering

Personality

Geography

North America50%

Asia25%

South America25%

Registration Source

Website Visitors100%

Job Title

Student67%

Executive33%

Organization

Private Practice25%

Academic Institution25%

Research Institute25%

Clinical Laboratory25%


Show Resources
Loading Comments...
Show Resources
Attendees
  • See more